{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:26:47Z","timestamp":1793806007640,"version":"4.6.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Oslo University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The non-invasive myocardial work index (MWI) has been validated in patients without aortic stenosis (AS). A thorough assessment of methodological limitations is warranted before this index can be applied to patients with AS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We simultaneously measured left ventricular pressure (LVP) by using a micromanometer-tipped catheter and obtained echocardiograms in 20 patients with severe AS. We estimated LVP curves and calculated pressure\u2013strain loops using three different models: (i) the model validated in patients without AS; (ii) the same model, but with pressure at the aortic valve opening (AVO) adjusted to diastolic cuff pressure; and (iii) a new model based on the invasive measurements from patients with AS. Valvular events were determined by echocardiography. Peak LVP was estimated as the sum of the mean aortic transvalvular gradient and systolic cuff pressure. In same-beat comparisons between invasive and estimated LVP curves, Model 1 significantly overestimated early systolic pressure by 61 \u00b1 5 mmHg at AVO compared with Models 2 and 3. However, the average correlation coefficients between estimated and invasive LVP traces were excellent for all models, and the overestimation had limited influence on MWI, with excellent correlation (r = 0.98, P &amp;lt; 0.001) and good agreement between the MWI calculated with estimated (all models) and invasive LVP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study confirms the validity of the non-invasive MWI in patients with AS. The accuracy of estimated LVP curves improved when matching AVO to the diastolic pressure in the original model, mirroring that of the AS-specific model. This may sequentially enhance the accuracy of regional MWI assessment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead227","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T18:43:10Z","timestamp":1694025790000},"page":"201-212","source":"Crossref","is-referenced-by-count":10,"title":["Non-invasive myocardial work in aortic stenosis: validation and improvement in left ventricular pressure estimation"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9847-4448","authenticated-orcid":false,"given":"Darijan","family":"Ribic","sequence":"first","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet , Oslo , Norway"},{"name":"Institute of Clinical Medicine, University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Espen W","family":"Remme","sequence":"additional","affiliation":[{"name":"Institute for Surgical Research, Oslo University Hospital, Rikshospitalet , Oslo , Norway"},{"name":"The Intervention Centre, Oslo University Hospital, Rikshospitalet , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto A","family":"Smiseth","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo , Norway"},{"name":"Institute for Surgical Research, Oslo University Hospital, Rikshospitalet , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Massey","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet , Oslo , Norway"},{"name":"Institute of Clinical Medicine, University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian H","family":"Eek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-7688","authenticated-orcid":false,"given":"John-Peder Escobar","family":"Kvitting","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , Oslo , Norway"},{"name":"Department of Cardiothoracic Surgery, Oslo University Hospital, Rikshospitalet , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet , Oslo , Norway"},{"name":"Institute of Clinical Medicine, University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-805X","authenticated-orcid":false,"given":"Kaspar","family":"Broch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet , 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