{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T10:45:55Z","timestamp":1751885155738,"version":"3.37.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007405","name":"The Danish Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Metropolitan Region of Denmark"},{"name":"Herlev & Gentofte Hospitals internal research fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Right ventricular free wall (RVFWLS) and four-chamber longitudinal strain (RV4CLS) are associated with adverse events in various patient populations including patients with heart failure (HF). We sought to investigate the prognostic value of RVFWLS and RV4CLS for the development of incident HF in participants from the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Participants from the 5th Copenhagen City Heart Study (2011\u20132015) without known chronic ischaemic heart disease or HF at baseline were included. RVFWLS and RV4CLS were obtained using two-dimensional speckle-tracking echocardiography from the right ventricular (RV)-focused apical four-chamber view. The primary endpoint was incident HF. Among 2740 participants (mean age 54 \u00b1 17 years, 42% male), 43 (1.6%) developed HF during a median follow-up of 5.5 years (IQR 4.5\u20136.3). Both RVFWLS and RV4CLS were associated with an increased risk of incident HF during follow-up independent of age, sex, hypertension, diabetes, body mass index and tricuspid annular plane systolic excursion (TAPSE), (HR 1.06, 95%CI 1.00\u20131.11, P = 0.034, per 1% absolute decrease and HR 1.14, 95%CI 1.05\u20131.23, P = 0.001, per 1% absolute decrease, respectively). Left ventricular ejection fraction (LVEF) modified the association between RV4CLS and incident HF (P for interaction = 0.016) such that RV4CLS was only of prognostic importance among those with LVEF &amp;lt; 55% (HR 1.21, 95%CI 1.11\u20131.33, P &amp;lt; 0.001 vs. HR 0.94, 95%CI 0.80\u20131.10, P = 0.43 in patients with LVEF \u2265 55%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In participants from the general population, both RVFWLS and RV4CLS were associated with a greater risk of incident HF independent of important baseline characteristics and TAPSE, and LVEF modified the relationship between RV4CLS and incident HF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead281","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T18:14:39Z","timestamp":1698257679000},"page":"396-403","source":"Crossref","is-referenced-by-count":4,"title":["Right ventricular free wall and four-chamber longitudinal strain in relation to incident heart failure in the general population"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-8862","authenticated-orcid":false,"given":"Caroline","family":"Espersen","sequence":"first","affiliation":[{"name":"Cardiac Non-Invasive Imaging Research Laboratory, The Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte Hospital , Gentofte Hospitalsvej 8, 3. th., 2900 Hellerup , Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Blegdamsvej 3, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-7511","authenticated-orcid":false,"given":"Kristoffer Grundtvig","family":"Skaarup","sequence":"additional","affiliation":[{"name":"Cardiac Non-Invasive Imaging Research Laboratory, The Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte Hospital , Gentofte Hospitalsvej 8, 3. th., 2900 Hellerup , Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Blegdamsvej 3, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats Christian H\u00f8jbjerg","family":"Lassen","sequence":"additional","affiliation":[{"name":"Cardiac Non-Invasive Imaging Research Laboratory, The Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte Hospital , Gentofte Hospitalsvej 8, 3. th., 2900 Hellerup , Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Blegdamsvej 3, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas Dyrby","family":"Johansen","sequence":"additional","affiliation":[{"name":"Cardiac Non-Invasive Imaging Research Laboratory, The Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte Hospital , Gentofte Hospitalsvej 8, 3. th., 2900 Hellerup , Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Blegdamsvej 3, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Hauser","sequence":"additional","affiliation":[{"name":"Cardiac Non-Invasive Imaging Research Laboratory, The Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte Hospital , Gentofte Hospitalsvej 8, 3. th., 2900 Hellerup , Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Blegdamsvej 3, 2200 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-663X","authenticated-orcid":false,"given":"Gorm Boje","family":"Jensen","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schnohr","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus","family":"M\u00f8gelvang","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital , Copenhagen , Denmark"},{"name":"The Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Cardiac Non-Invasive Imaging Research Laboratory, The Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte Hospital , Gentofte Hospitalsvej 8, 3. th., 2900 Hellerup , Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Blegdamsvej 3, 2200 Copenhagen , Denmark"},{"name":"The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital , Copenhagen , Denmark"},{"name":"The Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"2024022222395282200_jead281-B1","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/CIRCULATIONAHA.106.632208","article-title":"Right ventricular function and failure","volume":"114","author":"Voelkel","year":"2006","journal-title":"Circulation"},{"key":"2024022222395282200_jead281-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc 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