{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:30:38Z","timestamp":1788449438877,"version":"build-2803163510"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","award":["18-R125-A8534-22083"],"award-info":[{"award-number":["18-R125-A8534-22083"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Metropolitan Region of Denmark"},{"DOI":"10.13039\/501100002918","name":"Copenhagen University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002918","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fru Asta Florida Boldings Mindelegat"},{"DOI":"10.13039\/501100008267","name":"Kong Christian den Tiendes Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008267","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondsb\u00f8rsvekselerer Henry Hansen og Hustrus Hovedlegat"},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Copenhagen University Hospital\u2014Herlev and Gentofte"},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pressure-strain loop (PSL) analysis is a novel echocardiographic tool capable of assessing myocardial work non-invasively. In this study, we aim to evaluate the prognostic value of myocardial work indices in the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This was a prospective community-based cohort study (n = 4466). PSL analyses were performed to acquire global work index (GWI), global constructive work (GCW), global wasted work, and global work efficiency (GWE). The endpoint was a composite of heart failure or cardiovascular death (HF\/CVD). Survival analysis was applied. A total of 3932 participants were included in this analysis (median age: 58 years, 43% men). Of these, 124 (3%) experienced the outcome during a median follow-up period of 3.5 years [interquartile range (IQR): 2.6\u20134.4 years]. Hypertension significantly modified the association between all work indices and outcome (P for interaction &amp;lt; 0.05), such that work indices posed a higher risk of outcome in non-hypertensive than in hypertensive participants. After adjusting for Atherosclerosis Risk in Communities (ARIC)-HF risk variables, all work indices predicted outcome in non-hypertensive participants, but only GWI, GCW, and GWE predicted outcome in hypertensive participants [GWI: hazard ratio (HR) = 1.12 (1.07\u20131.16), per 100\u2005mmHg% decrease; GCW: HR = 1.12 (1.08\u20131.17), per 100\u2005mmHg% decrease; GWE: HR = 1.08 (1.04\u20131.12), per 1% decrease]. Only GWE significantly increased C-statistics when added to ARIC-HF risk variables in hypertensive participants (C-stat 0.865 vs. 0.877, P for increment = 0.003).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Hypertension modifies the association between myocardial work indices and HF\/CVD in the general population. All work indices are associated with outcome in normotensive participants. GWI, GCW, and GWE are independently associated with outcome in hypertension, but only GWE improves risk prediction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead292","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T16:47:12Z","timestamp":1699289232000},"page":"413-424","source":"Crossref","is-referenced-by-count":8,"title":["Association between myocardial work indices and cardiovascular events according to hypertension in the general population"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-8375","authenticated-orcid":false,"given":"Flemming Javier","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Gentofte Hospitalsvej 1 , Hellerup 2900, Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, Copenhagen 2400 , Denmark"},{"name":"Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, Copenhagen 2200 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-7511","authenticated-orcid":false,"given":"Kristoffer Grundtvig","family":"Skaarup","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Gentofte Hospitalsvej 1 , Hellerup 2900, Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, Copenhagen 2400 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-582X","authenticated-orcid":false,"given":"Mats Christian H\u00f8jbjerg","family":"Lassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Gentofte Hospitalsvej 1 , Hellerup 2900, Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, Copenhagen 2400 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-3236","authenticated-orcid":false,"given":"Niklas Dyrby","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Gentofte Hospitalsvej 1 , Hellerup 2900, Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, Copenhagen 2400 , Denmark"},{"name":"Department of Biomedical Sciences, University of Copenhagen , Blegdamsvej 3B, Copenhagen 2200 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorm Boje","family":"Jensen","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, Copenhagen 2400 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schnohr","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, Copenhagen 2400 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-4190","authenticated-orcid":false,"given":"Jacob Louis","family":"Marott","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, Copenhagen 2400 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"S\u00f8gaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014North Zealand , Dyrehavevej 29, Hilleroed 3400 , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, Copenhagen 2200 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Gentofte Hospitalsvej 1 , Hellerup 2900, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, Copenhagen 2200 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Hastrup","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, Copenhagen 2200 , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9, Copenhagen 2100 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"M\u00f8gelvang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, Copenhagen 2200 , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Blegdamsvej 9, Copenhagen 2100 , Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark , Campusvej 55, Odense 5230 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Moene","family":"Aalen","sequence":"additional","affiliation":[{"name":"Institute for Surgical Research, Oslo University Hospital and University of Oslo, Rikshospitalet , Sognsvannsveien 20, Oslo 0372 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3005-9954","authenticated-orcid":false,"given":"Otto 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