{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:06Z","timestamp":1792794726255,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["12ZZN22N"],"award-info":[{"award-number":["12ZZN22N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["1832917N"],"award-info":[{"award-number":["1832917N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["T002919N"],"award-info":[{"award-number":["T002919N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Health Science and Technology Program of Zhejiang Province","award":["2020KY165"],"award-info":[{"award-number":["2020KY165"]}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation Of Zhejiang Province","doi-asserted-by":"publisher","award":["LY21H020006"],"award-info":[{"award-number":["LY21H020006"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research Clinical Lectureship","doi-asserted-by":"publisher","award":["NIHR31225"],"award-info":[{"award-number":["NIHR31225"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Left bundle branch pacing (LBBP) has been shown to better maintain electrical synchrony compared with right ventricular pacing (RVP), but little is known about its impact on mechanical synchrony. This study investigates whether LBBP better preserves left ventricular (LV) mechanical synchronicity and function compared with RVP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Sixty patients with pacing indication for bradycardia were included: LBBP (n = 31) and RVP (n = 29). Echocardiography was performed before and shortly after pacemaker implantation and at 1-year follow-up. The lateral wall\u2013septal wall (LW\u2013SW) work difference was used as a measure of mechanical dyssynchrony. Septal flash, apical rocking, and septal strain patterns were also assessed. At baseline, LW\u2013SW work difference was small and similar in two groups. SW was markedly decreased, while LW work remained mostly unchanged in RVP, resulting in a larger LW\u2013SW work difference compared with LBBP (1253 \u00b1 687\u2005mmHg\u00b7% vs. 439 \u00b1 408\u2005mmHg\u00b7%, P &amp;lt; 0.01) at last follow-up. In addition, RVP more often induced septal flash or apical rocking and resulted in more advanced strain patterns compared with LBBP. At 1 year follow-up, LV ejection fraction (EF) and global longitudinal strain (GLS) were more decreased in RVP compared with LBBP (\u0394LVEF: \u22127.4 \u00b1 7.0% vs. 0.3 \u00b1 4.1%; \u0394LVGLS: \u22124.8 \u00b1 4.0% vs. \u22121.4 \u00b1 2.5%, both P &amp;lt; 0.01). In addition, \u0394LW\u2013SW work difference was independently correlated with LV adverse remodelling (r = 0.42, P &amp;lt; 0.01) and LV dysfunction (\u0394LVEF: r = \u22120.61, P &amp;lt; 0.01 and \u0394LVGLS: r = \u22120.38, P = 0.02).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LBBP causes less LV mechanical dyssynchrony than RVP as it preserves a more physiologic electrical conduction. As a consequence, LBBP appears to preserve LV function better than RVP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead296","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:13:31Z","timestamp":1699355611000},"page":"328-336","source":"Crossref","is-referenced-by-count":22,"title":["Left bundle branch pacing better preserves ventricular mechanical synchrony than right ventricular pacing: a two-centre study"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-6329","authenticated-orcid":false,"given":"Yankai","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou , China"},{"name":"Department of Cardiovascular Sciences, KU Leuven , Herestraat 49, Leuven 3000 , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-5753","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Duchenne","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven , Herestraat 49, Leuven 3000 , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-1035","authenticated-orcid":false,"given":"Christophe","family":"Garweg","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven , Herestraat 49, Leuven 3000 , Belgium"},{"name":"Department of Cardiovascular Diseases, University Hospitals Leuven , Herestraat 49 , Leuven 3000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , East Qingchun Road 3 , Hangzhou 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , East Qingchun Road 3 , Hangzhou 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , East Qingchun Road 3 , Hangzhou 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , East Qingchun Road 3 , Hangzhou 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , East Qingchun Road 3 , Hangzhou 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-4621","authenticated-orcid":false,"given":"Maria F","family":"Paton","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven , Herestraat 49, Leuven 3000 , Belgium"},{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, Multidisciplinary Cardiovascular Research Centre, University of Leeds , Leeds , UK"},{"name":"Leeds Cardiovascular Clinical Research Facility, Leeds Teaching Hospitals NHS Trust , Leeds , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9454-7706","authenticated-orcid":false,"given":"Alexis","family":"Puvrez","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven , Herestraat 49, Leuven 3000 , Belgium"},{"name":"Department of Cardiovascular Diseases, University Hospitals Leuven , Herestraat 49 , Leuven 3000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"V\u00f6ros","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven , Herestraat 49, Leuven 3000 , Belgium"},{"name":"Department of Cardiovascular Diseases, University Hospitals Leuven , Herestraat 49 , Leuven 3000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-0717","authenticated-orcid":false,"given":"Guosheng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, 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