{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:58:29Z","timestamp":1780919909091,"version":"3.54.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Biotronik AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of the study is to assess the impact of the baseline plaque composition on the DREAMS 3G luminal late loss and to compare the serial plaque changes between baseline and 6 and 12 months (M) follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 116 patients were enrolled in the BIOMAG-I trial. Patients were imaged with optical coherence tomography (OCT) pre- and post-DREAMS 3G implantation and at 6 and 12 M. OCTPlus software uses artificial intelligence to assess composition (i.e. lipid, calcium, and fibrous tissue) of the plaque. The differences between the OCT-derived minimum lumen area (MLA) post-percutaneous coronary intervention and 12 M were grouped into three terciles. Patients with larger MLA differences at 12 M (P = 0.0003) had significantly larger content of fibrous tissue at baseline. There was a reduction of 24.8% and 20.9% in lipid area, both P &amp;lt; 0.001, between the pre-DREAMS 3G OCT and the 6 and 12 M follow-up. Conversely, the fibrous tissue increased by 48.4% and 36.0% at 6 and 12 M follow-up, both P &amp;lt; 0.001.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The larger the fibrous tissue in the lesion at baseline, the larger the luminal loss seen at 6 and 12 M. Following the implantation of DREAMS 3G, favourable healing of the vessel coronary wall occurs as shown by a decrease in the lipid area and an increase in fibrous tissue.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead299","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T06:34:15Z","timestamp":1699425255000},"page":"491-497","source":"Crossref","is-referenced-by-count":8,"title":["Temporal changes in coronary plaque as assessed by an artificial intelligence\u2013based optical coherence tomography: from the first-in-human trial on DREAMS 3G scaffold"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-0471","authenticated-orcid":false,"given":"Hector M","family":"Garcia-Garcia","sequence":"first","affiliation":[{"name":"Interventional Cardiology, MedStar Washington Hospital Center , 110 Irving Street NW, Suite 4B-1, Washington, DC 20010 , 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, 110 Irving Street NW, Suite 4B-1, Washington, DC 20010 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-7728","authenticated-orcid":false,"given":"Adrian","family":"Wlodarczak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miedziowe Centrum Zdrowia SA , Lubin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kerai","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, MedStar Washington Hospital Center , 110 Irving Street NW, Suite 4B-1, Washington, DC 20010 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly B","family":"Levine","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, MedStar Washington Hospital Center , 110 Irving Street NW, Suite 4B-1, Washington, DC 20010 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 J","family":"van der Schaaf","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, OLVG , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Torzewski","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Oberallg\u00e4u-Kempten , Kempten , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Ferdinande","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Oost Limburg (ZOL) , Genk , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-0112","authenticated-orcid":false,"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital Clinico San Carlos IDISSC, Complutense University of Madrid , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Cardiology Division, University Hospital of Geneva , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8301-4517","authenticated-orcid":false,"given":"Johan","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-9091","authenticated-orcid":false,"given":"Gabor G","family":"Toth","sequence":"additional","affiliation":[{"name":"Division Cardiology, Medical University Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6836-2559","authenticated-orcid":false,"given":"Michael","family":"Joner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz- und Kreislauferkrankungen, 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