{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:44:05Z","timestamp":1791607445200,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-11-EQPX-0030"],"award-info":[{"award-number":["ANR-11-EQPX-0030"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-22-CPJ2-0009-01"],"award-info":[{"award-number":["ANR-22-CPJ2-0009-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-21-CE17-0034-01"],"award-info":[{"award-number":["ANR-21-CE17-0034-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programme d\u2019Investissements d\u2019Avenir","award":["ANR-10-IAHU04-LIRYC"],"award-info":[{"award-number":["ANR-10-IAHU04-LIRYC"]}]},{"name":"European Council","award":["ERC n715093"],"award-info":[{"award-number":["ERC n715093"]}]},{"DOI":"10.13039\/100007354","name":"Lefoulon-Delalande Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007369","name":"Institute of France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To identify clinical correlates of myocardial T1\u03c1 and to examine how myocardial T1\u03c1 values change under various clinical scenarios.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 66 patients (26% female, median age 57 years [Q1\u2013Q3, 44\u201365 years]) with known structural heart disease and 44 controls (50% female, median age 47 years [28\u201357 years]) underwent cardiac magnetic resonance imaging at 1.5\u2005T, including T1\u03c1 mapping, T2 mapping, native T1 mapping, late gadolinium enhancement, and extracellular volume (ECV) imaging. In controls, T1\u03c1 positively related with T2 (P = 0.038) and increased from basal to apical levels (P &amp;lt; 0.001). As compared with controls and remote myocardium, T1\u03c1 significantly increased in all patients\u2019 sub-groups and all types of myocardial injuries: acute and chronic injuries, focal and diffuse tissue abnormalities, as well as ischaemic and non-ischaemic aetiologies (P &amp;lt; 0.05). T1\u03c1 was independently associated with T2 in patients with acute injuries (P = 0.004) and with native T1 and ECV in patients with chronic injuries (P &amp;lt; 0.05). Myocardial T1\u03c1 mapping demonstrated good intra- and inter-observer reproducibility (intraclass correlation coefficient = 0.86 and 0.83, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Myocardial T1\u03c1 mapping appears to be reproducible and equally sensitive to acute and chronic myocardial injuries, whether of ischaemic or non-ischaemic origins. It may thus be a contrast-agent-free biomarker for gaining new and quantitative insight into myocardial structural disorders. These findings highlight the need for further studies through prospective and randomized trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead319","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T14:27:58Z","timestamp":1700317678000},"page":"548-557","source":"Crossref","is-referenced-by-count":13,"title":["Assessment of myocardial injuries in ischaemic and non-ischaemic cardiomyopathies using magnetic resonance T1-rho mapping"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2845-8617","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Bustin","sequence":"first","affiliation":[{"name":"IHU LIRYC, Electrophysiology and Heart Modeling Institute, Universit\u00e9 de Bordeaux, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045 , Avenue du Haut L\u00e9v\u00eaque, 33604 Pessac , France"},{"name":"Department of Cardiovascular Imaging, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux , Avenue de Magellan, 33604 Pessac , France"},{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne , Rue du Bugnon 46, 1011 Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Pineau","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Imaging, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux , Avenue de Magellan, 33604 Pessac , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Sridi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Imaging, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux , Avenue de Magellan, 33604 Pessac , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud B","family":"van Heeswijk","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne , Rue du Bugnon 46, 1011 Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ja\u00efs","sequence":"additional","affiliation":[{"name":"IHU LIRYC, Electrophysiology and Heart Modeling Institute, Universit\u00e9 de Bordeaux, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045 , Avenue du Haut L\u00e9v\u00eaque, 33604 Pessac , France"},{"name":"Department of Cardiac Electrophysiology, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux , Avenue de Magellan, 33604 Pessac , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Stuber","sequence":"additional","affiliation":[{"name":"IHU LIRYC, Electrophysiology and Heart Modeling Institute, Universit\u00e9 de Bordeaux, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045 , Avenue du Haut L\u00e9v\u00eaque, 33604 Pessac , France"},{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne , Rue du Bugnon 46, 1011 Lausanne , Switzerland"},{"name":"Center for Biomedical Imaging (CIBM) , Rue du Bugnon 46, 1011 Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Cochet","sequence":"additional","affiliation":[{"name":"IHU LIRYC, Electrophysiology and Heart Modeling Institute, Universit\u00e9 de Bordeaux, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045 , Avenue du Haut L\u00e9v\u00eaque, 33604 Pessac , France"},{"name":"Department of Cardiovascular Imaging, H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux , Avenue de Magellan, 33604 Pessac , 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