{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:47:13Z","timestamp":1782956833376,"version":"3.54.5"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Capital Region of Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Mitral regurgitation (MR) can be difficult to quantify. We sought to investigate whether the MR jet area to left atrial (LA) area ratio (MR\/LA ratio) method for quantifying MRs can be used to predict incident atrial fibrillation (AF) in the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The study included 4466 participants from the 5th Copenhagen City Heart Study, a prospective general population study, who underwent transthoracic echocardiography. MR jet area was measured and indexed to LA area. The endpoint was incident AF. MR was quantified in 4042 participants (mean age: 57 years, 43% men). Of these, 198 (4.9%) developed AF during a median follow-up period of 5.3 years (interquartile range: 4.4\u20136.1 years). MR was present in 1938 participants (48%) including 1593 (39%) trace\/mild MRs (MR\/LA ratio \u2264 20% and \u22644\u2005cm2). In unadjusted analysis, MR\/LA ratio was associated with incident AF [HR: 1.06 (1.00\u20131.13), P = 0.042 per 5% increase] but not after adjusting for CHARGE-AF score. However, the association was modified by age (P for interaction = 0.034), such that MR\/LA ratio was associated with AF only in participants \u2264 73 years. In these participants, MR\/LA ratio \u2018was\u2019 independently associated with AF after adjusting for CHARGE-AF score [HR: 1.14 (1.06\u20131.24), P = 0.001, per 5% increase]. This finding persisted when restricting the analysis to participants without moderate or severe MR and normal LA size [HR: 1.35 (1.09\u20131.68), P = 0.005, per 5% increase].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>MR, including even trace regurgitations quantified by MR\/LA ratio, is independently associated with incident AF in individuals \u2264 73 years of age.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead337","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T01:51:59Z","timestamp":1702345919000},"page":"579-586","source":"Crossref","is-referenced-by-count":12,"title":["Even mild mitral regurgitation is associated with incident atrial fibrillation in the general population"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1098-3579","authenticated-orcid":false,"given":"Marat","family":"Yafasov","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Niels Andersens Vej 65, entrance 8, 3rd floor on the right, p. 835, 2900 Hellerup , Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-8375","authenticated-orcid":false,"given":"Flemming Javier","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Niels Andersens Vej 65, entrance 8, 3rd floor on the right, p. 835, 2900 Hellerup , Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Shabib","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Niels Andersens Vej 65, entrance 8, 3rd floor on the right, p. 835, 2900 Hellerup , Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-7511","authenticated-orcid":false,"given":"Kristoffer Grundtvig","family":"Skaarup","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Niels Andersens Vej 65, entrance 8, 3rd floor on the right, p. 835, 2900 Hellerup , Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-582X","authenticated-orcid":false,"given":"Mats Christian H\u00f8jbjerg","family":"Lassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Niels Andersens Vej 65, entrance 8, 3rd floor on the right, p. 835, 2900 Hellerup , Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-3236","authenticated-orcid":false,"given":"Niklas Dyrby","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Niels Andersens Vej 65, entrance 8, 3rd floor on the right, p. 835, 2900 Hellerup , Denmark"},{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Dept. of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus T","family":"Jensen","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"},{"name":"Steno Diabetes Center Copenhagen , Borgmester Ib Juuls Vej 83, 2730 Herlev , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-663X","authenticated-orcid":false,"given":"Gorm Boje","family":"Jensen","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schnohr","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"M\u00f8gelvang","sequence":"additional","affiliation":[{"name":"The Copenhagen City Heart Study, Copenhagen University Hospital\u2014Herlev Hospital, Borgmester Ib Juuls Vej 73, opgang 7, 4. etage, M1, 2730 Herlev , Copenhagen , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4209-2778","authenticated-orcid":false,"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Niels Andersens Vej 65, entrance 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