{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:22:33Z","timestamp":1784290953472,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL130563"],"award-info":[{"award-number":["HL130563"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AHA16CSA28880004"],"award-info":[{"award-number":["AHA16CSA28880004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AHA19SRG34950011"],"award-info":[{"award-number":["AHA19SRG34950011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL130563"],"award-info":[{"award-number":["HL130563"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AHA16CSA28880004"],"award-info":[{"award-number":["AHA16CSA28880004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AHA19SRG34950011"],"award-info":[{"award-number":["AHA19SRG34950011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL130563"],"award-info":[{"award-number":["HL130563"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL093148"],"award-info":[{"award-number":["HL093148"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In systemic light-chain (AL) amyloidosis, quantification of right ventricular (RV) amyloid burden has been limited and the pathogenesis of RV dysfunction is poorly understood. Using 18F-florbetapir positron emission tomography\/computed tomography (PET\/CT), we aimed to quantify RV amyloid; correlate RV amyloid with RV structure and function; determine the independent contributions of RV, left ventricular (LV), and lung amyloid to RV function; and associate RV amyloid with major adverse cardiac events (MACE: death, heart failure hospitalization, cardiac transplantation).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We prospectively enrolled 106 participants with AL amyloidosis (median age 62 years, 55% males) who underwent 18F-florbetapir PET\/CT, magnetic resonance imaging, and echocardiography. 18F-florbetapir PET\/CT identified RV amyloid in 63% of those with and 40% of those without cardiac involvement by conventional criteria. RV amyloid burden correlated with RV ejection fraction (EF), RV free wall longitudinal strain (FWLS), RV wall thickness, RV mass index, N-terminal pro-brain natriuretic peptide, troponin T, LV amyloid, and lung amyloid (each P &amp;lt; 0.001). In multivariable analysis, RV amyloid burden, but not LV or lung amyloid burden, predicted RV dysfunction (EF P = 0.014; FWLS P &amp;lt; 0.001). During a median follow-up of 28 months, RV amyloid burden predicted MACE (P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study shows for the first time that 18F-florbetapir PET\/CT identifies early RV amyloid in systemic AL amyloidosis prior to alterations in RV structure and function. Increasing RV amyloid on 18F-florbetapir PET\/CT is associated with worse RV structure and function, predicts RV dysfunction, and predicts MACE. These results imply a central role for RV amyloid in the pathogenesis of RV dysfunction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jead350","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:34:20Z","timestamp":1704810860000},"page":"687-697","source":"Crossref","is-referenced-by-count":20,"title":["Quantification of right ventricular amyloid burden with 18F-florbetapir positron emission tomography\/computed tomography and its association with right ventricular dysfunction and outcomes in light-chain amyloidosis"],"prefix":"10.1093","volume":"25","author":[{"given":"Yesh","family":"Datar","sequence":"first","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital , 75 Francis St , Boston, MA 02115, USA"},{"name":"Division of Nuclear Medicine, Department of Radiology, Brigham and Women\u2019s Hospital , 75 Francis St , Boston, MA 02115, 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Cardiovascular Division and Department of Radiology, Brigham and Women\u2019s Hospital , 75 Francis St, Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital , 75 Francis St, Boston, MA 02115 , USA"},{"name":"Division of Nuclear Medicine, Department of Radiology, Brigham and Women\u2019s Hospital , 75 Francis St, Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Taylor","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital , 75 Francis St, Boston, MA 02115 , USA"},{"name":"Division of Nuclear Medicine, Department of Radiology, Brigham and Women\u2019s Hospital , 75 Francis St, Boston, MA 02115 , 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Francis St, Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital , 75 Francis St, Boston, MA 02115 , USA"},{"name":"Division of Hematology, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Yee","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Sanchorawala","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine , Boston, MA , 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