{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:13:01Z","timestamp":1792843981805,"version":"4.5.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T00:00:00Z","timestamp":1703376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Complete haematologic response to treatment for light chain cardiac amyloidosis (AL-CA) may lead to improvement of myocardial function and better outcomes. We sought to evaluate the effect of response to treatment for AL-CA on echocardiographic indices of myocardial deformation and work and their prognostic significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Sixty-one patients treated for AL were enrolled and underwent echocardiographic assessment at baseline and at 1 year. Patients were stratified according to haematologic response as complete or not complete responders. A significant reduction in median N-terminal pro-brain natriuretic peptide (NT-proBNP) (2771\u20131486 pg\/mL; P &amp;lt; 0.001) and posterior wall thickness (13\u201312 mm; P = 0.002) and an increase in global work index (GWI) (1115\u20131356 mmHg%; P = 0.018) was observed at 1 year. Patients with complete response (CR) had a more pronounced decrease in intraventricular septum thickness (14.2\u201312.0 mm; P = 0.006), improved global longitudinal strain (GLS) (\u221211.6 to \u221213.1%; P for interaction = 0.045), increased global constructive work (1245\u20131436 mmHg%; P = 0.008), and GWI (926\u20131250 mmHg%, P = 0.002) compared with non-CR. Furthermore, deltaGLS (\u03c1spearman = 0.35; P &amp;lt; 0.001) and deltaGWI (\u03c1spearman = \u22120.32; P = 0.02) correlated with delta NT-proBNP. Importantly, patients with GLS and GWI response had a better prognosis (log-rank P = 0.048 and log-rank P = 0.007, respectively). After adjustment for Mayo stage, gender, and response status, deltaGLS [hazard ratio (HR) = 1.404, P = 0.046 per 1% increase] and deltaGWI (HR = 0.996, P = 0.042 per 1mmHg% increase) were independent predictors of survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Complete haematologic response to treatment is associated with improved left ventricular myocardial work indices, and their change is associated with improved survival in AL-CA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jead351","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:39:38Z","timestamp":1703183978000},"page":"698-707","source":"Crossref","is-referenced-by-count":13,"title":["Left ventricular myocardial work improves in response to treatment and is associated with survival among patients with light chain cardiac amyloidosis"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-9670","authenticated-orcid":false,"given":"Alexandros","family":"Briasoulis","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Bampatsias","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Petropoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Rempakos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Patras","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Theodorakakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Makris","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios Athanasios","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7609-0087","authenticated-orcid":false,"given":"Kimon","family":"Stamatelopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Faculty of Medicine, National and Kapodistrian University of Athens , Vassilisis Sofias 80, Athens 11528 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,24]]},"reference":[{"key":"2024042923573280500_jead351-B1","doi-asserted-by":"crossref","first-page":"s30","DOI":"10.7861\/clinmedicine.18-2-s30","article-title":"Cardiac amyloidosis","volume":"18","author":"Martinez-Naharro","year":"2018","journal-title":"Clin Med (Lond)"},{"key":"2024042923573280500_jead351-B2","doi-asserted-by":"crossref","first-page":"e454","DOI":"10.1097\/HS9.0000000000000454","article-title":"Systemic AL amyloidosis: current approaches to diagnosis and 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