{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:31:05Z","timestamp":1793169065189,"version":"4.5.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"MedTrace"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Myocardial perfusion imaging (MPI) using [15O]H2O positron emission tomography (PET) is used to guide the selection of patients with angina for invasive angiography and possible revascularization. Our study evaluated (i) whether atrial fibrillation (AF) reduces global hyperaemic myocardial blood flow (MBF) and (ii) whether [15O]H2O PET MPI effectively guides revascularization procedures for patients with ongoing AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We prospectively recruited 346 patients with angina and persistent or paroxysmal AF referred for baseline\/hyperaemic [15O]H2O PET MPI. The primary outcome was revascularization within 3 months of MPI. In the analyses, patients were divided into four groups based on whether they had ongoing AF or sinus rhythm (SR) and whether they had previously documented coronary artery disease (CAD) or not. Thus, four groups were compared: SR-noCAD, AF-noCAD, SR-CAD, and AF-CAD. Hyperaemic MBF was affected by both ongoing AF and prior CAD [MBF (mL\/min\/g): 2.82 (SR-noCAD) vs. 2.12 (AF-noCAD) vs. 2.22 (SR-CAD) vs. 1.80 (AF-CAD), two-way analysis of variance P &amp;lt; 0.0001]. In multiple linear regression, ongoing AF was independently associated with reduced hyperaemic MBF. Every 0.1\u2005mL\/min\/g decrease in hyperaemic MBF was associated with a 23% increase in odds of early revascularization. Receiver operating characteristic (ROC) analysis of vessel-specific hyperaemic MBF to predict early revascularization yielded the following areas under the ROC curve: SR-noCAD: 0.95 (P &amp;lt; 0.0001); AF-noCAD: 0.79 (P &amp;lt; 0.0001); SR-CAD: 0.78 (P &amp;lt; 0.0001); and AF-CAD: 0.88 (P &amp;lt; 0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Ongoing AF is associated with 19\u201325% reduced global hyperaemic MBF as measured by [15O]H2O MPI PET. Regardless, vessel-specific hyperaemic MBF still predicts early revascularization in patients with AF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae043","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T15:46:38Z","timestamp":1708443998000},"page":"958-967","source":"Crossref","is-referenced-by-count":6,"title":["Guiding early revascularization using [15O]H2O positron emission tomography myocardial perfusion imaging: impact of atrial fibrillation"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-5329","authenticated-orcid":false,"given":"Simon","family":"Madsen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, Aarhus N DK-8200 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-2207","authenticated-orcid":false,"given":"Mette Louise Gram","family":"Kjaerulff","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, Aarhus N DK-8200 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-7396","authenticated-orcid":false,"given":"June Anita","family":"Ejlersen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Nuclear Medicine, Regional Hospital Viborg , Viborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-3869","authenticated-orcid":false,"given":"Bent Roni","family":"Rangh\u00f8j Nielsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-9253","authenticated-orcid":false,"given":"Lars","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3121-0938","authenticated-orcid":false,"given":"Jens","family":"S\u00f6rensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, Aarhus N DK-8200 , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard , 998200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8105-7046","authenticated-orcid":false,"given":"Lars Poulsen","family":"Tolbod","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, Aarhus N DK-8200 , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard , 998200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-1305","authenticated-orcid":false,"given":"Lars Christian","family":"Gormsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, Aarhus N DK-8200 , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard , 998200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"2024062723545091500_jeae043-B1","doi-asserted-by":"crossref","first-page":"8118","DOI":"10.3390\/ijms21218118","article-title":"Ischemic heart disease pathophysiology paradigms overview: from plaque activation to microvascular dysfunction","volume":"21","author":"Severino","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2024062723545091500_jeae043-B2","doi-asserted-by":"crossref","first-page":"e007417","DOI":"10.1161\/CIRCIMAGING.117.007417","article-title":"Impact of revascularization on absolute myocardial blood flow as assessed by serial [15O]H2O positron emission tomography imaging","volume":"11","author":"Driessen","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"2024062723545091500_jeae043-B3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.7326\/0003-4819-157-10-201211200-00010","article-title":"Diagnosis of stable ischemic heart disease: summary of a clinical practice guideline from the American College of Physicians\/American College of Cardiology Foundation\/American Heart Association\/American Association for Thoracic Surgery\/Preventive Cardiovascular Nurses Association\/Society of Thoracic Surgeons","volume":"157","author":"Qaseem","year":"2012","journal-title":"Ann Intern Med"},{"key":"2024062723545091500_jeae043-B4","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/CIRCULATIONAHA.109.915009","article-title":"Cardiac positron emission tomography\/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease","volume":"122","author":"Kajander","year":"2010","journal-title":"Circulation"},{"key":"2024062723545091500_jeae043-B5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jacc.2018.10.056","article-title":"Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis","volume":"73","author":"Driessen","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2024062723545091500_jeae043-B6","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jacc.2014.05.069","article-title":"Quantitative assessment of myocardial perfusion in the detection of significant coronary artery disease: cutoff values and diagnostic accuracy of quantitative [(15)O]H2O PET imaging","volume":"64","author":"Danad","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2024062723545091500_jeae043-B7","doi-asserted-by":"crossref","first-page":"oead044","DOI":"10.1093\/ehjopen\/oead044","article-title":"Myocardial perfusion imaging by 15O-H2O positron emission tomography predicts clinical revascularization procedures in symptomatic patients with previous CABG","volume":"3","author":"Vester","year":"2023","journal-title":"Eur Heart J Open"},{"key":"2024062723545091500_jeae043-B8","doi-asserted-by":"crossref","first-page":"e15123","DOI":"10.14814\/phy2.15123","article-title":"Hyperemic myocardial blood flow in patients with atrial fibrillation before and after catheter ablation: a dynamic stress CT perfusion study","volume":"9","author":"Takafuji","year":"2021","journal-title":"Physiol Rep"},{"key":"2024062723545091500_jeae043-B9","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1093\/eurheartj\/ehm246","article-title":"Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation","volume":"28","author":"Range","year":"2007","journal-title":"Eur Heart J"},{"key":"2024062723545091500_jeae043-B10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2967\/jnumed.108.055665","article-title":"Myocardial perfusion in nonischemic dilated cardiomyopathy with and without atrial fibrillation","volume":"50","author":"Range","year":"2009","journal-title":"J Nucl Med"},{"key":"2024062723545091500_jeae043-B11","doi-asserted-by":"crossref","first-page":"e009218","DOI":"10.1161\/JAHA.118.009218","article-title":"Myocardial perfusion is impaired and relates to cardiac dysfunction in patients with atrial fibrillation both before and after successful catheter ablation","volume":"7","author":"Wijesurendra","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2024062723545091500_jeae043-B12","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"64","author":"January","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2024062723545091500_jeae043-B13","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s00259-011-1730-3","article-title":"Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET\/CT scanner","volume":"38","author":"Harms","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2024062723545091500_jeae043-B14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"2024062723545091500_jeae043-B15","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2337\/dc19-2172","article-title":"Reduced myocardial perfusion reserve in type 2 diabetes is caused by increased perfusion at rest and decreased maximal perfusion during stress","volume":"43","author":"S\u00f8rensen","year":"2020","journal-title":"Diabetes Care"},{"key":"2024062723545091500_jeae043-B16","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0735-1097(97)00327-6","article-title":"Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus","volume":"30","author":"Yokoyama","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"2024062723545091500_jeae043-B17","first-page":"1029","article-title":"Atrial fibrillation is more frequently associated with nonobstructive coronary lesions: the Bialystok Coronary Project","volume":"130","author":"Tomaszuk-Kazberuk","year":"2020","journal-title":"Pol Arch Intern Med"},{"key":"2024062723545091500_jeae043-B18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.hjc.2017.03.001","article-title":"Characteristics of coronary artery disease among patients with atrial fibrillation compared to patients with sinus rhythm","volume":"58","author":"Motloch","year":"2017","journal-title":"Hell J Cardiol"},{"key":"2024062723545091500_jeae043-B19","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/clc.23490","article-title":"Prevalence of atrial fibrillation dependent on coronary artery status: insights from the LIFE-Heart Study","volume":"43","author":"Kornej","year":"2020","journal-title":"Clin Cardiol"},{"key":"2024062723545091500_jeae043-B20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/europace\/eup404","article-title":"Myocardial perfusion imaging does not adequately assess the risk of coronary artery disease in patients with atrial fibrillation","volume":"12","author":"Smit","year":"2010","journal-title":"Europace"},{"key":"2024062723545091500_jeae043-B21","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJMoa2206606","article-title":"Percutaneous revascularization for ischemic left ventricular dysfunction","volume":"387","author":"Perera","year":"2022","journal-title":"N Engl J Med"},{"key":"2024062723545091500_jeae043-B22","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1915922","article-title":"Initial invasive or conservative strategy for stable coronary disease","volume":"382","author":"Maron","year":"2020","journal-title":"N Engl J Med"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/advance-article-pdf\/doi\/10.1093\/ehjci\/jeae043\/56740640\/jeae043.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/25\/7\/958\/58339585\/jeae043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/25\/7\/958\/58339585\/jeae043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T23:55:39Z","timestamp":1719532539000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/25\/7\/958\/7611406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,2,20]]},"published-print":{"date-parts":[[2024,6,28]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jeae043","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,2,20]]}}}