{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:12:41Z","timestamp":1793211161907,"version":"4.5.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000850","name":"National Heart and Lung Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011056","name":"British Society for Heart Failure Research Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011056","id-type":"DOI","asserted-by":"publisher"}]},{"name":"British Heart Foundation Clinical Research Training Fellowship","award":["FS\/CRTF\/23\/24444"],"award-info":[{"award-number":["FS\/CRTF\/23\/24444"]}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alexander Jansons Myocarditis UK Foundation"},{"name":"BHF Intermediate Clinical Research Fellowship","award":["FS\/ICRF\/21\/26019"],"award-info":[{"award-number":["FS\/ICRF\/21\/26019"]}]},{"name":"MRC Clinician Scientist Fellowship","award":["MR\/W023830\/1"],"award-info":[{"award-number":["MR\/W023830\/1"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/18\/4\/34215"],"award-info":[{"award-number":["RE\/18\/4\/34215"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["SP\/17\/11\/32885"],"award-info":[{"award-number":["SP\/17\/11\/32885"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royston Centre for Cardiomyopathy Research"},{"DOI":"10.13039\/501100000282","name":"Sir Jules Thorn Charitable Trust","doi-asserted-by":"publisher","award":["21JTA"],"award-info":[{"award-number":["21JTA"]}],"id":[{"id":"10.13039\/501100000282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal Brompton Cardiovascular Biomedical Research Unit"},{"name":"NIHR Imperial College Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to compare the association between measures of left atrial (LA) structure and function, derived from cardiovascular magnetic resonance (CMR), with cardiovascular death or non-fatal heart failure events in patients with non-ischaemic dilated cardiomyopathy (DCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>CMR studies of 580 prospectively recruited patients with DCM in sinus rhythm [median age 54 (interquartile range 44\u201364) years, 61% men, median left ventricular ejection fraction 42% (30\u201351%)] were analysed for measures of LA structure [LA maximum volume index (LAVImax) and LA minimum volume index (LAVImin)] and function (LA emptying fraction, LA reservoir strain, LA conduit strain (LACS), and LA booster strain]. Over a median follow-up of 7.4 years, 103 patients (18%) met the primary endpoint. Apart from LACS, each measure of LA structure and function was associated with the primary endpoint after adjusting for other important prognostic variables. The addition of each LA metric to a baseline model containing the same important prognostic covariates improved model discrimination, with LAVImin providing the greatest improvement [C-statistic improvement: 0.702\u20130.738; \u03c72 test comparing likelihood ratio P &amp;lt; 0.0001; categorical net reclassification index: 0.210 (95% CI 0.023\u20130.392)]. Patients in the highest tercile of LAVImin had similar event rates to those with persistent atrial fibrillation. Measures of LA strain did not enhance model discrimination above LA volumetric measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Measures of LA structure and function offer important prognostic information in patients with DCM and enhance the prediction of adverse outcomes. LA strain was not incremental to volumetric analysis for risk prediction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae080","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T13:27:00Z","timestamp":1710595620000},"page":"1566-1574","source":"Crossref","is-referenced-by-count":11,"title":["Comparative prognostic importance of measures of left atrial structure and function in non-ischaemic dilated cardiomyopathy"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-5993","authenticated-orcid":false,"given":"Daniel J","family":"Hammersley","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , Sydney Street, London SW3 6NP ,","place":["UK"]},{"name":"Royal Brompton and Harefield Hospital, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust , London 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Brompton and Harefield Hospital, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E","family":"Jones","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , Sydney Street, London SW3 6NP ,","place":["UK"]},{"name":"Royal Brompton and Harefield Hospital, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust , London ,","place":["UK"]},{"name":"Essex Cardiothoracic Centre , Basildon ,","place":["UK"]},{"name":"Anglia Ruskin University , Chelmsford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Mach","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , Sydney Street, London SW3 6NP ,","place":["UK"]},{"name":"Royal Brompton and Harefield Hospital, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust , London 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Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Fuwai Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudley J","family":"Pennell","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , Sydney Street, London SW3 6NP ,","place":["UK"]},{"name":"Royal Brompton and Harefield Hospital, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upasana","family":"Tayal","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , Sydney Street, London SW3 6NP ,","place":["UK"]},{"name":"Royal Brompton and Harefield Hospital, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust , London 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