{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:53:51Z","timestamp":1783050831242,"version":"3.54.6"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Left ventricular global longitudinal strain (LVGLS) is a known outcome predictor in transcatheter edge-to-edge repair (TEER) for functional mitral regurgitation (MR). We aimed to assess its prognostic yield in the setting of TEER for chronic primary MR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We conducted a single-centre, retrospective analysis of 323 consecutive patients undergoing isolated, first-time procedures. Stratified by baseline LVGLS quartiles (\u2264\u221219%, \u221218.9% to \u221216%, \u221215.9% to \u221212%, &amp;gt;\u221212%), the cohort was evaluated for the primary composite outcome of all-cause mortality or heart failure hospitalizations, as well as secondary endpoints consisting of mitral reinterventions and the persistence of significant residual MR and\/or functional disability\u2014all along the first year after intervention. Subjects with worse (i.e. less negative) LVGLS exhibited higher comorbidity, more advanced HF, and elevated procedural risk. Post-TEER, those belonging to the worst LVGLS quartile group sustained increased mortality (16.9% vs. 6.3%, Log-Rank P = 0.005, HR 1.75, 95% CI 1.08\u20134.74, P = 0.041) and, when affected by LV dysfunction\/dilatation, more primary outcome events (21.1% vs. 11.5%, Log-Rank P = 0.037, HR 1.68, 95% CI 1.02\u20135.46, P = 0.047). No association was demonstrated between baseline LVGLS and other endpoints. Upon exploratory analysis, 1-month post-procedural LVGLS directly correlated with and was worse than its baseline counterpart by 1.6%, and a more impaired 1-month value\u2014but not the presence\/extent of deterioration\u2014conferred heightened risk for the primary outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>TEER for chronic primary MR is feasible, safe, and efficacious irrespective of baseline LVGLS. Yet, worse baseline LVGLS forecasts a less favourable post-procedural course, presumably reflecting a higher-risk patient profile.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae083","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T21:09:02Z","timestamp":1711487342000},"page":"1164-1176","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic value of left ventricular global longitudinal strain in transcatheter edge-to-edge repair for chronic primary mitral regurgitation"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9670-4026","authenticated-orcid":false,"given":"Alon","family":"Shechter","sequence":"first","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 , USA"},{"name":"Department of Cardiology, Rabin Medical Center , 39 Jabotinsky St, Petach Tikva 4941492 , Israel"},{"name":"Faculty of Medicine, Tel Aviv University , 35 Klachkin St, Tel Aviv 6997801 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria J","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danon","family":"Kaewkes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 , USA"},{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-3531","authenticated-orcid":false,"given":"Vivek","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Visrodia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Ryan","family":"Tacon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Koren","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 , USA"},{"name":"Rappaport Faculty of Medicine, Technion Israel Institute of Technology , Haifa , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Koseki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 , USA"},{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagasaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 , USA"},{"name":"Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine , Maebashi, Gunma , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabah","family":"Skaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 , 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