{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:20:06Z","timestamp":1780683606461,"version":"3.54.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aimed to assess the impact of adenosine on quantitative myocardial blood flow (MBF) in a rapid stress\u2013rest protocol compared with a rest\u2013stress protocol using 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI) and to gain insights into the time dependency of such effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Quantitative MBF at rest (rMBF) and during adenosine-induced stress (sMBF) and myocardial flow reserve (MFR) were obtained from 331 retrospectively identified patients who underwent 13N-ammonia PET MPI for suspected chronic coronary syndrome and who all exhibited no perfusion defects. Of these, 146 (44.1%) underwent a rapid stress\u2013rest protocol with a time interval (\u0394tstress\u2013rest) of 20 \u00b1 4\u2005min between adenosine infusion offset and rest imaging, as per clinical routine. The remaining 185 (55.9%) patients underwent a rest\u2013stress protocol and served as the reference. Groups did not differ regarding demographics, risk factors, medication, left ventricular function, and calcium scores. rMBF was significantly higher in the stress\u2013rest vs. the rest\u2013stress group [0.80 (interquartile range 0.66\u20131.00) vs. 0.70 (0.58\u20130.83) mL\u00b7min\u22121\u00b7g\u22121, P &amp;lt; 0.001], and, as sMBF was identical between groups [2.52 (2.20\u20132.96) vs. 2.50 (1.96\u20133.11), P = 0.347], MFR was significantly lower in the stress\u2013rest group [3.07 (2.43\u20133.88) vs. 3.50 (2.63\u20134.10), P = 0.007]. There was a weak correlation between \u0394tstress\u2013rest and rMBF (r = \u22120.259, P = 0.002) and between \u0394tstress\u2013rest and MFR (r = 0.163, P = 0.049), and the proportion of patients with abnormally high rMBF was significantly decreasing with increasing \u0394tstress\u2013rest.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Intravenously applied adenosine induces a long-lasting hyperaemic effect on the myocardium. Consequently, rapid stress\u2013rest protocols could lead to an overestimation of rMBF and an underestimation of MFR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae096","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T07:15:46Z","timestamp":1712560546000},"page":"1367-1373","source":"Crossref","is-referenced-by-count":3,"title":["Duration of adenosine-induced myocardial hyperaemia: insights from quantitative 13N-ammonia positron emission tomography myocardial perfusion imaging"],"prefix":"10.1093","volume":"25","author":[{"given":"Chrysoula","family":"Garefa","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik F","family":"Sager","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal S","family":"Heiniger","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Markendorf","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobia","family":"Albertini","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stjepan","family":"Jurisic","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Gajic","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gebhard","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik C","family":"Benz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aju P","family":"Pazhenkottil","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas A","family":"Giannopoulos","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr J","family":"Slomka","sequence":"additional","affiliation":[{"name":"Division of Artificial Intelligence in Medicine, Imaging, and Biomedical Sciences, Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-8904","authenticated-orcid":false,"given":"Ronny R","family":"Buechel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich , NUK A 12, Ramistrasse 100, Zurich 8091 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