{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:35:49Z","timestamp":1769121349341,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005302","name":"Onassis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005302","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Grant & Support Program for Scholars\u2019 Association members","award":["RZP 001\/2019\u20132020"],"award-info":[{"award-number":["RZP 001\/2019\u20132020"]}]},{"name":"King\u2019s Together Multi and Interdisciplinary Research Scheme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Hypertensive patients of African ancestry (Afr-a) have higher incidences of heart failure and worse clinical outcomes than hypertensive patients of European ancestry (Eu-a), yet the underlying mechanisms remain misunderstood. This study investigated right (RV) and left (LV) ventricular remodelling alongside myocardial tissue derangements between Afr-a and Eu-a hypertensives.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>63 Afr-a and 47 Eu-a hypertensives underwent multi-parametric cardiovascular magnetic resonance. Biventricular volumes, mass, function, mass\/end-diastolic volume (M\/V) ratios, T2 and pre-\/post-contrast T1 relaxation times, synthetic extracellular volume, and myocardial fibrosis (MF) were measured. 3D shape modelling was implemented to delineate ventricular geometry. LV and RV mass (indexed to body-surface-area) and M\/V ratio were significantly greater in Afr-a than Eu-a hypertensives (67.1 \u00b1 21.7 vs. 58.3 \u00b1 16.7\u2005g\/m2, 12.6 \u00b1 3.48 vs. 10.7 \u00b1 2.71\u2005g\/m2, 0.79 \u00b1 0.21 vs. 0.70 \u00b1 0.14\u2005g\/mL, and 0.16 \u00b1 0.04 vs. 0.13 \u00b1 0.03\u2005g\/mL, respectively; P &amp;lt; 0.03). Afr-a patients showed greater basal interventricular septum thickness than Eu-a patients, influencing LV hypertrophy and RV cavity changes. This biventricular remodelling was associated with prolonged T2 relaxation time (47.0 \u00b1 2.2 vs. 45.7 \u00b1 2.2\u2005ms, P = 0.005) and higher prevalence (23% vs. 4%, P = 0.001) and extent of MF [2.3 (0.6\u201314.3) vs. 1.6 (0.9\u20132.5) % LV mass, P = 0.008] in Afr-a patients. Multivariable linear regression showed that modifiable cardiovascular risk factors and greater end-diastolic volume, but not ethnicity, were independently associated with greater LV mass.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Afr-a hypertensives had distinctive biventricular remodelling, including increased RV mass, septal thickening and myocardial tissue abnormalities compared with Eu-a hypertensives. From this study, modifiable cardiovascular risk factors and ventricular geometry, but not ethnicity, were independently associated with greater LV myocardial mass.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae097","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T13:17:12Z","timestamp":1712755032000},"page":"901-911","source":"Crossref","is-referenced-by-count":3,"title":["Ethnicity differences in geometric remodelling and myocardial composition in hypertension unveiled by cardiovascular magnetic resonance"],"prefix":"10.1093","volume":"25","author":[{"given":"Georgios","family":"Georgiopoulos","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, St Thomas\u2019 Hospital , Room ST0404253 4th Floor Lambeth Wing, St Thomas\u2019 Hospital Campus, Westminster Bridge Road, London SE1 7EH , UK"},{"name":"Department of Clinical Therapeutics, National and 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