{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:45:14Z","timestamp":1791085514319,"version":"4.1.0"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Diastolic dysfunction refers to impaired relaxation or filling of the ventricles during the diastolic phase of the cardiac cycle. Left ventricular diastolic dysfunction (LVDD) is common in hypertensive individuals and is associated with increased morbidity and mortality. LVDD serves as a critical precursor to heart failure, particularly heart failure with preserved ejection fraction. The pathophysiology of LVDD in hypertension is complex, involving alterations in cardiac structure and function, neurohormonal activation, and vascular stiffness. While the diagnosis of LVDD relies primarily on echocardiography, management remains challenging due to a lack of specific treatment guidelines for LVDD. This review offers an overview of the pathophysiological mechanisms underlying LVDD in hypertension, diagnostic methods, clinical manifestations, strategies for managing LVDD, and prospects for future research.<\/jats:p>","DOI":"10.1093\/ehjci\/jeae178","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T18:04:17Z","timestamp":1721239457000},"page":"1525-1536","source":"Crossref","is-referenced-by-count":41,"title":["Diastolic dysfunction in hypertension: a comprehensive review of pathophysiology, diagnosis, and treatment"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-6216","authenticated-orcid":false,"given":"Camilla Ikast","family":"Ottosen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Center for Translational Cardiology and Pragmatic Randomized Trials (CTCPR), Herlev & Gentofte Hospital, University of Copenhagen , Gentofte Hospitalsvej 8, 2900 Hellerup ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Nadruz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, State University of Campinas , Campinas, SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo M","family":"Inciardi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas Dyrby","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center for Translational Cardiology and Pragmatic Randomized Trials (CTCPR), Herlev & Gentofte Hospital, University of Copenhagen , Gentofte Hospitalsvej 8, 2900 Hellerup ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , Durham, NC ,","place":["USA"]},{"name":"Duke Clinical Research Institute , Durham, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4209-2778","authenticated-orcid":false,"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center for Translational Cardiology and Pragmatic Randomized Trials (CTCPR), Herlev & Gentofte Hospital, University of Copenhagen , Gentofte Hospitalsvej 8, 2900 Hellerup ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"2024103010321330500_jeae178-B1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mcna.2016.08.013","article-title":"Diastolic dysfunction and hypertension","volume":"101","author":"Nadruz","year":"2017","journal-title":"Med Clin North Am"},{"key":"2024103010321330500_jeae178-B2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jacc.2013.10.063","article-title":"Pre-clinical diastolic dysfunction","volume":"63","author":"Wan","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2024103010321330500_jeae178-B3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.mcna.2009.02.013","article-title":"Diastolic dysfunction as a link between hypertension and heart failure","volume":"93","author":"Verma","year":"2009","journal-title":"Med Clin North Am"},{"key":"2024103010321330500_jeae178-B4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11906-009-0048-z","article-title":"Therapeutic approaches to diastolic dysfunction","volume":"11","author":"Janardhanan","year":"2009","journal-title":"Curr Hypertens Rep"},{"key":"2024103010321330500_jeae178-B5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/ajh.2010.235","article-title":"Diagnosis and management of left ventricular diastolic dysfunction in the hypertensive patient","volume":"24","author":"Galderisi","year":"2011","journal-title":"Am J Hypertens"},{"key":"2024103010321330500_jeae178-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jhh.2014.36","article-title":"Myocardial remodeling in hypertension","volume":"29","author":"Nadruz","year":"2015","journal-title":"J Hum Hypertens"},{"key":"2024103010321330500_jeae178-B7","author":"Mancia"},{"key":"2024103010321330500_jeae178-B8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/01.CIR.96.1.308","article-title":"Hemodynamic patterns of age-related changes in blood pressure. 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