{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:13:57Z","timestamp":1780960437831,"version":"3.54.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Studies have demonstrated the importance of forward flow, and specifically of stroke volume (SV) and SV index (SVI), as prognostic markers in different cardiovascular diseases. In this study, we aim to evaluate the association between SV and SVI thresholds and prognosis in patients with severe primary mitral regurgitation (MR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The association between either SV (&amp;lt;55, 55\u201370, and &amp;gt;70\u2005mL) or SVI (&amp;lt;30, 30\u201335, and &amp;gt;35\u2005mL\/m2) thresholds and all-cause mortality and heart failure (HF) hospitalizations was examined in a retrospective analysis of 283 patients [60% male, median age 70 years, interquartile range (IQR) 58\u201382] with severe primary MR, normal left ventricular size and systolic function, and no other significant left-sided valvular abnormalities. Compared with normal values, SV &amp;lt; 55\u2005mL was found to be associated with worse outcomes (hazard ratio 1.8, IQR 1.1\u20132.8, P = 0.016), whereas SV between 55 and 70\u2005mL was not. A non-significant trend for worse outcomes was noted for SVI &amp;lt; 35\u2005mL\/m2 compared with normal SVI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with severe primary MR, SV &amp;lt; 55\u2005mL was found to be associated with increased rates of HF hospitalization and all-cause mortality. This easily obtainable parameter may allow for better risk stratification of patients with primary MR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae249","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T02:31:24Z","timestamp":1727231484000},"page":"307-312","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic value of echocardiographic-derived stroke volume in severe primary mitral regurgitation"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3863-4493","authenticated-orcid":false,"given":"Yoav","family":"Granot","sequence":"first","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]},{"name":"Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10019 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheizaf","family":"Gefen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Karlsberg","sequence":"additional","affiliation":[{"name":"Leon H. Chaney Division of Cardiology, Department of Medicine, NYU Langone Health , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Ran Sapir","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]},{"name":"Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Laufer Perl","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zahler","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Viskin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel","family":"Banai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-802X","authenticated-orcid":false,"given":"Yan","family":"Topilsky","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-2698","authenticated-orcid":false,"given":"Ofer","family":"Havakuk","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University , 6 Weizmann Street, Tel Aviv 6423906 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"2025013023573236200_jeae249-B1","first-page":"1","article-title":"Mitral valve regurgitation","volume":"9","author":"O'Rourke","year":"1984","journal-title":"Curr Probl Cardiol"},{"key":"2025013023573236200_jeae249-B2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/01.CIR.67.3.593","article-title":"Noninvasive Doppler determination of cardiac output in man. 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