{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:42:27Z","timestamp":1794282147366,"version":"4.9.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Limited data exist on echocardiographic predictors of weaning from veno-arterial extracorporeal membrane oxygenation (V-A ECMO). We aimed to test the performance of different echocardiographic indices to predict weaning from V-A ECMO and free survival after weaning<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Observational study including patients with cardiogenic shock submitted to V-AECMO. Echocardiography was performed after V-AECMO placement and daily during the weaning trial to assess cardiac recovery. Echocardiography data after V-A ECMO implantation and during the last weaning trial before V-A ECMO removal were analysed. Besides traditional parameters, total isovolumic time (t-IVT, a left ventricular performance index) and mitral annular plane systolic excursion (MAPSE) were also tested. Seventy-six patients were included. A greater ventricular velocity time integral (LVOT VTI) at baseline was associated with a five-fold increase in weaning success (P &amp;lt; 0.001) as MAPSE lateral &amp;gt;6.15\u2005mm (P = 0.001) did. TAPSE and S\u2032 at tricuspid annulus showed an analogous association. During the weaning trial t-IVT, LVEF, MAPSE, LVOT VTI, and TAPSE all improved significantly (P &amp;lt; 0.001 for all). At regression analysis t-IVT &amp;lt;14.4\u2005s\/min (&amp;lt;0.001), LVOT VTI &amp;gt;12.3\u2005cm (P &amp;lt; 0.001), MAPSE &amp;gt; 8.9\u2005mm (P &amp;lt; 0.001), TAPSE &amp;gt; 16\u2005mm (&amp;lt;0.001), and E\/e\u02b9 &amp;lt; 15.5 (P = 0.001) were associated with weaning success and free survival after weaning. LVEF did not predict the weaning success and survival at any time-point (P = 0.230).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Longitudinal function, t-IVT and native ejection, measured with LVOT VTI, are reliable parameters to predict weaning success in V-A ECMO whereas the LVEF, although dynamically changing during weaning trial, it is not.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae274","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T19:11:37Z","timestamp":1729710697000},"page":"359-367","source":"Crossref","is-referenced-by-count":16,"title":["Echocardiographic parameters for weaning from extracorporeal membrane oxygenation\u2014the role of longitudinal function and cardiac time intervals"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-5138","authenticated-orcid":false,"given":"Guido","family":"Tavazzi","sequence":"first","affiliation":[{"name":"Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia , VIale Golgi 19, Pavia 27100 ,","place":["Italy"]},{"name":"Anesthesia and Intensive Care, Fondazione Policlinico San Matteo Hospital IRCCS , VIale Golgi 19, Pavia 27100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza Natalia Julia","family":"Colombo","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care, Fondazione Policlinico San Matteo Hospital IRCCS , VIale Golgi 19, Pavia 27100 ,","place":["Italy"]},{"name":"PhD in Experimental Medicine, University of Pavia , Via Ferrata 5, Pavia 27100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0314-8548","authenticated-orcid":false,"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epidemiology and Biostatistics, Fondazione IRCCS Policlinico S. 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