{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:28:04Z","timestamp":1793291284507,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["HI22C0154"],"award-info":[{"award-number":["HI22C0154"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Patients with moderate aortic stenosis (AS) show a poor prognosis if they have high-risk features. We investigated herein the incremental prognostic value of left ventricular (LV) and left atrial (LA) strain in patients with moderate AS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In a cohort of 923 patients with moderate AS (median age 74 years, men 55%, aortic valve area 1.18 [interquartile range (IQR) 1.08\u20131.30] cm2, mean pressure gradient 25 [IQR 23\u201330] mmHg), the LV global longitudinal strain (LV-GLS) and LA reservoir strain (LARS) were measured using speckle-tracking echocardiography. Absolute values of myocardial strain were used. The primary endpoint was a composite of all-cause mortality and heart failure hospitalization. During a median of 5.9 years, the primary endpoint occurred in 186 patients (20.2%). The median LV-GLS and LARS were 17.7% (IQR 14.8\u201319.7%) and 24.5% (IQR 18.7\u201329.3%), respectively. LV-GLS [adjusted hazard ratio (HR) 0.92, 95% confidence interval (CI) 0.87\u20130.97] and LARS (adjusted HR 0.97, 95% CI 0.95\u20130.99) were significant predictors of the primary outcome, independent of clinical and echocardiographic variables, including LV ejection fraction. Notably, the prognostic value of LV-GLS was stronger than that of LARS, remaining significant after further adjustment for LARS. LV-GLS &amp;lt; 17% and LARS &amp;lt; 22% were identified as optimal cut-offs for the primary outcome. Patients with both reduced LV-GLS and LARS had the worst outcomes (log-rank P &amp;lt; 0.001). LV-GLS &amp;lt; 17% and LARS &amp;lt; 22% had incremental prognostic values on top of other clinical and echocardiographic variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In moderate AS, reduced LV-GLS and LARS have incremental prognostic values and can refine risk stratification to identify high-risk patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae285","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:37:31Z","timestamp":1730806651000},"page":"96-103","source":"Crossref","is-referenced-by-count":14,"title":["Incremental prognostic value of left ventricular and left atrial strains in moderate aortic stenosis"],"prefix":"10.1093","volume":"26","author":[{"given":"Hyun-Jung","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-4156","authenticated-orcid":false,"given":"Seo-Yeon","family":"Gwak","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-5410","authenticated-orcid":false,"given":"Iksung","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-3304","authenticated-orcid":false,"given":"Geu-Ru","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-2958","authenticated-orcid":false,"given":"Jong-Won","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6136-0136","authenticated-orcid":false,"given":"Chi Young","family":"Shim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Severance 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