{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:36:54Z","timestamp":1772138214354,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008810","name":"New South Wales Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009021","name":"Heart Research Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011727","name":"Stockholm County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>More than 90% of patients with left bundle branch block (LBBB) and reduced left ventricular (LV) ejection fraction have LV dyssynchrony and a high probability of response to cardiac resynchronization therapy (CRT). A subgroup of patients with non-specific intraventricular conduction delay (IVCD) have a LBBB-like LV activation pattern when studied using invasive mapping and advanced echocardiographic techniques. These patients also frequently benefit from CRT, but these patients have proven difficult to identify using electrocardiogram criteria. Cardiovascular magnetic resonance (CMR) imaging indices of dyssynchrony may identify patients with IVCD who may benefit from CRT, but their relative accuracies for identification of LV dyssynchrony remain unknown. We compared the LV dyssynchrony classification accuracy of two commonly available CMR indices in a study population of patients with severely reduced LV ejection fraction and no scar and either LBBB or QRS duration &amp;lt;120 ms and normal QRS axis (controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In LBBB (n = 44) and controls (n = 36), using CMR feature-tracking circumferential strain, dyssynchrony was quantified as the circumferential uniformity ratio estimate (CURE) and the systolic stretch index (SSI). Deidentified CMR image data were made publicly available. Both CURE and SSI quantified more severe dyssynchrony in LBBB compared with controls (P&amp;lt;0.001 for both). SSI more frequently discriminated LBBB and normal conduction LV activation patterns than CURE [area under the receiver-operating characteristic curve (95% confidence interval) 0.96 (0.92\u20131.00) for SSI vs. 0.76 (0.65\u20130.86) for CURE, P &amp;lt; 0.001].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SSI is superior to CURE for discriminating synchronous and dyssynchronous LV activation and should be further studied in the setting of non-LBBB conduction abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae301","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T15:25:45Z","timestamp":1732202745000},"page":"435-443","source":"Crossref","is-referenced-by-count":0,"title":["Accuracy of left ventricular mechanical dyssynchrony indices for mechanical characteristics of left bundle branch block using cardiovascular magnetic resonance feature tracking"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2118-3056","authenticated-orcid":false,"given":"Daniel E","family":"Loewenstein","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet , SE-171 76 Stockholm ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-0008","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Wieslander","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet , SE-171 76 Stockholm ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-3326","authenticated-orcid":false,"given":"Einar","family":"Heiberg","sequence":"additional","affiliation":[{"name":"Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Sk\u00e5ne University Hospital , Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5591-2344","authenticated-orcid":false,"given":"Jimmy","family":"Axelsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet , SE-171 76 Stockholm ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-9470","authenticated-orcid":false,"given":"Igor","family":"Klem","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke University Medical Center , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-6363","authenticated-orcid":false,"given":"Robin","family":"Nijveldt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-4437","authenticated-orcid":false,"given":"Erik B","family":"Schelbert","sequence":"additional","affiliation":[{"name":"Allina Health Minneapolis Heart Institute at United Hospital , St. Paul, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5828-0015","authenticated-orcid":false,"given":"Peder","family":"S\u00f6rensson","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna, Karolinska Institutet , and Department of Cardiology, Karolinska University Hospital, SE-171 76 Stockholm ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-4458","authenticated-orcid":false,"given":"Andreas","family":"Sigfridsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet , SE-171 76 Stockholm ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-3297","authenticated-orcid":false,"given":"David G","family":"Strauss","sequence":"additional","affiliation":[{"name":"Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration , Silver Spring, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond J","family":"Kim","sequence":"additional","affiliation":[{"name":"Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-3668","authenticated-orcid":false,"given":"Brett D","family":"Atwater","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Inova Schar Heart and Vascular , Fairfax, VA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-2038","authenticated-orcid":false,"given":"Martin","family":"Ugander","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet , SE-171 76 Stockholm ,","place":["Sweden"]},{"name":"Kolling Institute, Royal North Shore Hospital, and University of Sydney , St Leonards, Sydney, NSW 2065 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"2025030423204678400_jeae301-B1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/CIRCULATIONAHA.110.960898","article-title":"Effectiveness of cardiac resynchronization therapy by QRS morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT)","volume":"123","author":"Zareba","year":"2011","journal-title":"Circulation"},{"key":"2025030423204678400_jeae301-B2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCULATIONAHA.112.097709","article-title":"Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: results from the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) study","volume":"126","author":"Gold","year":"2012","journal-title":"Circulation"},{"key":"2025030423204678400_jeae301-B3","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"2025030423204678400_jeae301-B4","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.amjcard.2010.11.010","article-title":"Defining left bundle branch block in the era of cardiac resynchronization therapy","volume":"107","author":"Strauss","year":"2011","journal-title":"Am J Cardiol"},{"key":"2025030423204678400_jeae301-B5","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1540-8159.2012.03427.x","article-title":"Electrocardiographic criteria of true left bundle branch block: a simple sign to predict a better clinical and instrumental response to CRT","volume":"35","author":"Mascioli","year":"2012","journal-title":"Pacing Clin Electrophysiol"},{"key":"2025030423204678400_jeae301-B6","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/europace\/eut049","article-title":"True complete left bundle branch block morphology strongly predicts good response to cardiac resynchronization therapy","volume":"15","author":"Tian","year":"2013","journal-title":"Europace"},{"key":"2025030423204678400_jeae301-B7","first-page":"118","article-title":"The role of electrocardiography in the elaboration of a new paradigm in cardiac resynchronization therapy for patients with nonspecific intraventricular conduction disturbance","volume":"13","author":"Vereckei","year":"2016","journal-title":"J Geriatr Cardiol"},{"key":"2025030423204678400_jeae301-B8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1161\/CIRCULATIONAHA.122.062124","article-title":"Cardiac resynchronization therapy improves outcomes in patients with intraventricular conduction delay but not right bundle branch block: a patient-level meta-analysis of randomized controlled trials","volume":"147","author":"Friedman","year":"2023","journal-title":"Circulation"},{"key":"2025030423204678400_jeae301-B9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ijcard.2016.09.078","article-title":"Predictors of response to cardiac resynchronization therapy: a systematic review","volume":"225","author":"Rickard","year":"2016","journal-title":"Int J Cardiol"},{"key":"2025030423204678400_jeae301-B10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ahj.2011.11.014","article-title":"Effect of QRS morphology on clinical event reduction with cardiac resynchronization therapy: meta-analysis of randomized controlled trials","volume":"163","author":"Sipahi","year":"2012","journal-title":"Am Heart J"},{"key":"2025030423204678400_jeae301-B11","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1540-8159.2004.00592.x","article-title":"The spectrum of inter- and intraventricular conduction abnormalities in patients eligible for cardiac resynchronization therapy","volume":"27","author":"Peichl","year":"2004","journal-title":"Pacing Clin Electrophysiol"},{"key":"2025030423204678400_jeae301-B12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12968-017-0333-y","article-title":"Cardiovascular magnetic resonance myocardial feature tracking using a non-rigid, elastic image registration algorithm: assessment of variability in a real-life clinical setting","volume":"19","author":"Morais","year":"2017","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025030423204678400_jeae301-B13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1109\/TMI.2012.2230114","article-title":"Elastic image registration versus speckle tracking for 2-D myocardial motion estimation: a direct comparison in vivo","volume":"32","author":"Heyde","year":"2013","journal-title":"IEEE Trans Med Imaging"},{"key":"2025030423204678400_jeae301-B14","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1161\/CIRCULATIONAHA.104.508457","article-title":"Cardiac dyssynchrony analysis using circumferential versus longitudinal strain: implications for assessing cardiac resynchronization","volume":"111","author":"Helm","year":"2005","journal-title":"Circulation"},{"key":"2025030423204678400_jeae301-B15","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1161\/01.CIR.0000035037.11968.5C","article-title":"Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block","volume":"106","author":"Leclercq","year":"2002","journal-title":"Circulation"},{"key":"2025030423204678400_jeae301-B16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jcmg.2008.04.013","article-title":"Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy","volume":"1","author":"Bilchick","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025030423204678400_jeae301-B17","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.jcmg.2018.07.013","article-title":"Systolic stretch characterizes the electromechanical substrate responsive to cardiac resynchronization therapy","volume":"12","author":"Gorcsan","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025030423204678400_jeae301-B18","doi-asserted-by":"crossref","first-page":"e003744","DOI":"10.1161\/CIRCIMAGING.115.003744","article-title":"Differentiating electromechanical from non-electrical substrates of mechanical discoordination to identify responders to cardiac resynchronization therapy","volume":"8","author":"Lumens","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"2025030423204678400_jeae301-B19","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2017"},{"key":"2025030423204678400_jeae301-B20","author":"Wickham","year":"2017"},{"key":"2025030423204678400_jeae301-B21","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-98141-3","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2009"},{"key":"2025030423204678400_jeae301-B22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC bioinformatics"},{"key":"2025030423204678400_jeae301-B23","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.21105\/joss.04148","article-title":"SimplyAgree: an R package and jamovi module for simplifying agreement and reliability analyses","volume":"7","author":"Caldwell","year":"2022","journal-title":"J Open Source Softw"},{"key":"2025030423204678400_jeae301-B24","author":"Xie","year":"2017"},{"key":"2025030423204678400_jeae301-B25","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1056\/NEJMoa0706695","article-title":"Cardiac-resynchronization therapy in heart failure with narrow QRS complexes","volume":"357","author":"Beshai","year":"2007","journal-title":"N Engl J Med"},{"key":"2025030423204678400_jeae301-B26","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1306687","article-title":"Cardiac-resynchronization therapy in heart failure with a narrow QRS complex","volume":"369","author":"Ruschitzka","year":"2013","journal-title":"N Engl J Med"},{"key":"2025030423204678400_jeae301-B27","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.CIR.69.5.914","article-title":"Endocardial activation of left bundle branch block","volume":"69","author":"Vassallo","year":"1984","journal-title":"Circulation"},{"key":"2025030423204678400_jeae301-B28","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/01.CIR.0000118502.91105.F6","article-title":"Characterization of left ventricular activation in patients with heart failure and left bundle-branch block","volume":"109","author":"Auricchio","year":"2004","journal-title":"Circulation"},{"key":"2025030423204678400_jeae301-B29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijcha.2017.11.005","article-title":"The interaction of QRS duration with cardiac magnetic resonance derived scar and mechanical dyssynchrony in systolic heart failure: implications for cardiac resynchronization therapy","volume":"18","author":"Jackson","year":"2018","journal-title":"IJC Heart Vasc"},{"key":"2025030423204678400_jeae301-B30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1476-7120-7-53","article-title":"Functional measurements based on feature tracking of cine magnetic resonance images identify left ventricular segments with myocardial scar","volume":"7","author":"Maret","year":"2009","journal-title":"Cardiovasc Ultrasound"},{"key":"2025030423204678400_jeae301-B31","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jelectrocard.2012.09.001","article-title":"Differentiation between left bundle branch block and left ventricular hypertrophy: implications for cardiac resynchronization therapy","volume":"45","author":"Strauss","year":"2012","journal-title":"J Electrocardiol"},{"key":"2025030423204678400_jeae301-B32","doi-asserted-by":"crossref","first-page":"e12563","DOI":"10.1111\/anec.12563","article-title":"Comparison of four LBBB definitions for predicting mortality in patients receiving cardiac resynchronization therapy","volume":"23","author":"Jastrz\u0119bski","year":"2018","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2025030423204678400_jeae301-B33","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.ahj.2013.03.013","article-title":"Left ventricular mechanical dyssynchrony by cardiac magnetic resonance is greater in patients with strict vs nonstrict electrocardiogram criteria for left bundle-branch block","volume":"165","author":"Andersson","year":"2013","journal-title":"Am Heart J"},{"key":"2025030423204678400_jeae301-B34","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.jacc.2014.02.533","article-title":"Impact of mechanical activation, scar, and electrical timing on cardiac resynchronization therapy response and clinical outcomes","volume":"63","author":"Bilchick","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2025030423204678400_jeae301-B35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1148\/radiol.14141578","article-title":"Singular value decomposition applied to cardiac strain from MR imaging for selection of optimal cardiac resynchronization therapy candidates","volume":"275","author":"Ramachandran","year":"2015","journal-title":"Radiology"},{"key":"2025030423204678400_jeae301-B36","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1586\/14779072.2015.1049945","article-title":"Narrow QRS systolic heart failure: is there a target for cardiac resynchronization?","volume":"13","author":"Jackson","year":"2015","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"2025030423204678400_jeae301-B37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijcard.2014.04.268","article-title":"Feature-tracking cardiovascular magnetic resonance as a novel technique for the assessment of mechanical dyssynchrony","volume":"175","author":"Taylor","year":"2014","journal-title":"Int J Cardiol"},{"key":"2025030423204678400_jeae301-B38","doi-asserted-by":"crossref","first-page":"2048004017710142","DOI":"10.1177\/2048004017710142","article-title":"Quantitative assessment of left ventricular mechanical dyssynchrony using cine cardiovascular magnetic resonance imaging: inter-study reproducibility","volume":"6","author":"Kowallick","year":"2017","journal-title":"JRSM Cardiovasc Dis"},{"key":"2025030423204678400_jeae301-B39","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: developed by the task force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) with the special contribution of the European Heart Rhythm Association (EHRA)","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/advance-article-pdf\/doi\/10.1093\/ehjci\/jeae301\/61144778\/jeae301.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/26\/3\/435\/61144778\/jeae301.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/26\/3\/435\/61144778\/jeae301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T18:21:30Z","timestamp":1741112490000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/26\/3\/435\/7907209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,22]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,11,22]]},"published-print":{"date-parts":[[2025,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jeae301","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.11.11.22282225","asserted-by":"object"}]},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2024,11,22]]}}}