{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T02:09:08Z","timestamp":1794622148575,"version":"4.9.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171961 and 82211530116"],"award-info":[{"award-number":["82171961 and 82211530116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB212"],"award-info":[{"award-number":["2022CFB212"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Non-invasive myocardial work offers a promising echocardiographic method to evaluate left ventricular (LV) function as it integrates myocardial deformation and afterload. The study sought to investigate the association of myocardial work indices with post-operative LV dysfunction in patients with chronic severe aortic regurgitation (AR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Pre-operative LV ejection fraction (LVEF), LV global work index (LV GWI), LV global constructive work (LV GCW), LV global wasted work (LV GWW), and LV global work efficiency (LV GWE) were measured. Post-operative LV dysfunction was defined as LVEF &amp;lt; 50% at 12 months after surgery. One hundred and forty-one patients with chronic severe AR and preserved LVEF (52 (42\u201358) years; 74.5% men) who underwent aortic valve surgery were studied. Twenty-six patients (18%) developed post-operative LV dysfunction. Patients with post-operative LV dysfunction had lower LV GWI, LV GCW, and LV GWE compared with those without (all P &amp;lt; 0.05). In multivariate analysis, LV GWI (adjusted odds ratio (OR): 0.99; 95% CI: 0.98\u20131.00; P &amp;lt; 0.001), and LV GCW (adjusted OR: 0.99; 95% CI: 0.99\u20131.00; P &amp;lt; 0.001) were associated with post-operative LV dysfunction. Moreover, a multivariate logistic regression model with LV GWI (Akaike information criterion = 108.023, Bayesian information criterion = 119.818, C-statistics = 0.836) showed the best capability in predicting post-operative LV dysfunction. The comparative analysis of C-statistics across the three models\u2014LV GWI, LV GCW, and LV GLS\u2014did not reveal statistically significant differences (all P &amp;gt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with chronic severe AR and preserved LVEF, impaired myocardial work indices are associated with post-operative LV dysfunction. Myocardial work has potential value for risk stratification and surgical decision-making in such a population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae312","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T19:21:23Z","timestamp":1733858483000},"page":"654-663","source":"Crossref","is-referenced-by-count":6,"title":["Non-invasive myocardial work in severe aortic regurgitation: implications for post-operative left ventricular dysfunction"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-5013","authenticated-orcid":false,"given":"Yu-Ting","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Ultrasound, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu, Sichuan Province 610000 ,","place":["China"]},{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu, Sichuan Province 610000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abudukadier","family":"Abulipizi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei Province Key Laboratory of Molecular Imaging , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-6338","authenticated-orcid":false,"given":"Xiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei Province Key Laboratory of Molecular Imaging , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei Province Key Laboratory of Molecular Imaging , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5255-1299","authenticated-orcid":false,"given":"Ruo-Han","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei Province Key Laboratory of Molecular Imaging , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 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in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei Province Key Laboratory of Molecular Imaging , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Kun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei Province Key Laboratory of Molecular Imaging , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei Province Key Laboratory of Molecular Imaging , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-8199","authenticated-orcid":false,"given":"Yu-Man","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei 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Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hubei Province , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]},{"name":"Hubei Province Key Laboratory of Molecular Imaging , 1277 Jiefang Avenue, Wuhan, Hubei Province 430000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-9799","authenticated-orcid":false,"given":"Li","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu, Sichuan Province 610000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong 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