{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:17:42Z","timestamp":1788945462170,"version":"build-2803163510"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The positron emission tomography (PET) tracer 18F-florbetaben is a promising diagnostic tool for light-chain cardiac amyloidosis (AL-CA). A greater cardiac uptake might signal more amyloid burden and a worse outcome. We aimed to assess the prognostic significance of 18F-florbetaben uptake in AL-CA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive patients with AL-CA underwent 18F-florbetaben PET scans. Total amyloid burden (TAB; calculated as mean standardized uptake value multiplied by molecular volume) was assessed in the left and right ventricles (LV\/RV) in early (5\u201315\u2032) and late (50\u201360\u2032) acquisitions. The endpoint was all-cause mortality. Forty patients (median age 69 years, 73% males, Mayo 2004 Stage III in 80%) underwent 18F-florbetaben PET with a median time from tissue biopsy of 21 days (interquartile range, IQR 7\u201383). Late LV TAB, but not early LV TAB, correlated with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity (hs)-troponin T. Over 13 months after the PET scan (IQR 5\u201321), 65% of patients died. A late LV TAB \u2265273\u2005cm3 (cut-off derived from spline curve analysis) predicted 18 and 24 month all-cause mortality independently from baseline variables, including NT-proBNP, hs-troponin T, and Mayo 2004 stage. Late RV TAB \u2265135\u2005cm3 independently predicted 18 and 24 month all-cause mortality. Patients with both late LV and RV TAB \u2265 cut-offs had a shorter survival than those with only LV TAB \u2265 cut-off and those with TAB in both ventricles &amp;lt; cut-offs (Log-rank 16.52, P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>18F-florbetaben PET imaging offers valuable prognostic information in AL-CA. Values of late TAB measured in the LV and RV are strong predictors of all-cause mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeae332","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T08:22:22Z","timestamp":1734942142000},"page":"500-508","source":"Crossref","is-referenced-by-count":15,"title":["Estimated total amyloid burden from 18F-florbetaben positron emission tomography predicts all-cause mortality in light-chain cardiac amyloidosis"],"prefix":"10.1093","volume":"26","author":[{"given":"Giuseppe","family":"Vergaro","sequence":"first","affiliation":[{"name":"Health Science Interdisciplinary Center, Scuola Superiore Sant\u2019Anna , Piazza Martiri della Liberta\u00b4 33, 56127 Pisa ,","place":["Italy"]},{"name":"Division of Cardiology and Cardiovascular Medicine, Fondazione Toscana Gabriele Monasterio , Via Moruzzi 1, 56124 Pisa 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