{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:04:12Z","timestamp":1783098252906,"version":"3.54.6"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Forschungsimpulse","award":["SF_0051"],"award-info":[{"award-number":["SF_0051"]}]},{"name":"Federal Government of Lower Austria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Less pronounced calcification of the aortic valve (AVC) was observed in women with aortic stenosis (AS) when compared with men. Since women have smaller aortic valves (AVs), this could explain a lower calcium load. We aimed to analyse the association of AV size with AVC independent from sex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive patients with high-gradient AS, who underwent cardiac computed tomography (CT), were assessed. AV annulus area and AVC with the Agatston score were measured on CT. In total, 601 patients (mean age 80 \u00b1 7 years, 45% female) were included. Women had smaller AV annulus areas (4.12 \u00b1 0.67 vs. 5.15 \u00b1 0.78\u2005cm2, P &amp;lt; 0.001) and lower Agatston scores [2018 (1456\u20133017) vs. 3394 (2562\u20134530), P &amp;lt; 0.001] than men. We found a significant correlation (r = 0.594, P &amp;lt; 0.001) and independent association (\u03b2 = 926.20, P &amp;lt; 0.001) of AV annulus area with AVC. On separate regression analyses for men and women, AVC was independently associated with AV annulus area in both sexes (\u03b2men = 887.77; \u03b2women = 863.48, both P &amp;lt; 0.001). When patients were stratified into AV size quartiles, patients in the lower quartiles were more likely to have AVC values below recommended sex-specific AVC thresholds. In the lowest quartile, 28% of female and 27% of male patients had Agatston scores below 1200 Agatston units (AU) (women) and 2000\u2005AU (men), while this proportion decreased to 6 and 2%, respectively, in the quartiles with the largest annulus areas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In high-gradient AS, AVC strongly depends on AV annulus area. This association is not dependent on sex. Thus, AVC should be indexed to AV size in addition to sex.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf002","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T11:39:07Z","timestamp":1736941147000},"page":"557-565","source":"Crossref","is-referenced-by-count":4,"title":["Association of aortic valve size with the degree of aortic valve calcification in severe high-gradient aortic stenosis"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-9900","authenticated-orcid":false,"given":"Roya Anahita","family":"Mousavi","sequence":"first","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Lamm","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Will","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas A","family":"Kammerlander","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Krackowizer","sequence":"additional","affiliation":[{"name":"Institute of Medical Radiology, Diagnostics, Intervention, University Hospital Sankt Poelten , Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra Carmen","family":"Gunacker","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"H\u00f6bart","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Voith","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Felix","family":"Gr\u00fcninger","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Vock","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta C","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Paracelsus Medical University of Salzburg , Salzburg ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-1450","authenticated-orcid":false,"given":"Julia","family":"Mascherbauer","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences , Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems ,","place":["Austria"]},{"name":"Division of Internal Medicine 3 \/ Cardiology, University Hospital Sankt Poelten , Dunantplatz 1, 3100 Sankt Poelten ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"2025030423210139000_jeaf002-B1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll 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