{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:46:02Z","timestamp":1794336362057,"version":"4.9.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To identify differences in CT-derived perivascular adipose tissue (PVAT) and epicardial adipose tissue (EAT) characteristics that may indicate inflammatory status differences between post-treatment acute myocardial infarction (AMI) and stable coronary artery disease (CAD) patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A cohort of 205 post-AMI patients (age 59.8 \u00b1 9.2, 92.2% male) was propensity-matched with 205 stable CAD patients (age 60.5 \u00b1 10.0, 90.2% male). Coronary CT angiography and non-contrast CT scans were performed to assess PVAT mean attenuation across major coronary segments and EAT mean attenuation and volumes, respectively. For post-AMI patients, CT scans were conducted 28.6 \u00b1 13.8 days after the AMI incidence. Post-AMI patients showed higher non-culprit PVAT and EAT mean attenuation than stable CAD patients (8.01\u2005HU, 95% CI 5.90\u201310.11\u2005HU, P &amp;lt; 0.001, 2.48\u2005HU, 95% CI 0.83\u20134.13\u2005HU, P = 0.003, respectively). The EAT volume percentage at higher attenuation levels was higher in post-AMI patients compared with stable CAD (33.93 cm3, 95% CI 16.86\u201351.00 cm3, P &amp;lt; 0.001), with the difference maximized at the \u221270\u2005HU threshold (4.75%, 95% CI 3.64%\u20135.87%, P &amp;lt; 0.001). PVAT mean attenuation positively correlated with EAT mean attenuations and the percentage of EAT volume &amp;gt; \u221270\u2005HU (P &amp;lt; 0.001 for both).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Post-AMI patients showed higher PVAT and EAT attenuation than stable CAD patients, potentially indicating AMI-associated inflammatory cardiac adipose tissue changes. A total of \u221270\u2005HU can act as a potential cut-off for inflamed EAT. These findings highlight the potential of using CT-derived adipose tissue characteristics to assess inflammation and guide post-AMI management strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf019","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T20:08:02Z","timestamp":1737144482000},"page":"733-740","source":"Crossref","is-referenced-by-count":7,"title":["Characterizing cardiac adipose tissue in post-acute myocardial infarction patients via CT imaging: a comparative cross-sectional study"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-4109","authenticated-orcid":false,"given":"Xiaomeng","family":"Wang","sequence":"first","affiliation":[{"name":"Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Heart Center Singapore , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]},{"name":"Cardiovascular Sciences Academic Clinical Programme, Duke-National University of Singapore , 8 College Rd, 169857 Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-956X","authenticated-orcid":false,"given":"Philip D","family":"Adamson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Otago Christchurch , Christchurch ,","place":["New Zealand"]},{"name":"BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E","family":"Greer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Otago Christchurch , Christchurch ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute for Infocomm Research, Agency for Science, Technology and Research (A*Star) , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwee Kuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute, Agency for Science, Technology and Research (A*Star) , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Ting","family":"Loong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Heart Center Singapore , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Amirah Syahindah","family":"Raffiee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Heart Center Singapore , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching Hui","family":"Sia","sequence":"additional","affiliation":[{"name":"National University Heart Center Singapore , Singapore ,","place":["Singapore"]},{"name":"Yong Loo Lin School of Medicine, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swee Yaw","family":"Tan","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore , Singapore ,","place":["Singapore"]},{"name":"Department of Cardiovascular Medicine, National Heart Center Singapore , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sock Hwee","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette Li San","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, National University Hospital , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Lung","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Heart Center Singapore , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxun","family":"Yang","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-5864","authenticated-orcid":false,"given":"Min Sen","family":"Yew","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tan Tock Seng Hospital , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thon Hon","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changi General Hospital , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore , Singapore ,","place":["Singapore"]},{"name":"Department of Cardiovascular Medicine, National Heart Center Singapore , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]},{"name":"National Heart Research Institute Singapore, National Heart Centre , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]},{"name":"CVS.AI, National Heart Research Institute Singapore, National Heart Centre , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]},{"name":"Department of Biomedical Engineering, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslee J","family":"Shaw","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai , New York City, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Yan Yee","family":"Chan","sequence":"additional","affiliation":[{"name":"National University Heart Center Singapore , Singapore ,","place":["Singapore"]},{"name":"Yong Loo Lin School of Medicine, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J","family":"Hausenloy","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore , Singapore ,","place":["Singapore"]},{"name":"National Heart Research Institute Singapore, National Heart Centre , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]},{"name":"Yong Loo Lin School of Medicine, National University Singapore , Singapore ,","place":["Singapore"]},{"name":"The Hatter Cardiovascular Institute, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lohendran","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Heart Center Singapore , 5 Hospital Drive, 169609 Singapore ,","place":["Singapore"]},{"name":"Cardiovascular Sciences Academic Clinical Programme, Duke-National University of Singapore , 8 College Rd, 169857 Singapore ,","place":["Singapore"]},{"name":"National 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