{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:22:56Z","timestamp":1756570976242,"version":"3.40.3"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aims to describe the prevalence of discordant mild\/moderate aortic stenosis (AS) in a population-based study and to identify the mechanisms that lead to reduced stroke volume (SV) and discordant moderate AS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Discordant high-gradient (HG)-mild AS, defined as AVA &amp;gt; 1.5\u2005cm2 and mean pressure gradient (MG) of 20\u201340\u2005mmHg, and discordant low-gradient (LG) moderate AS, defined as AVA 1.0\u20131.5\u2005cm2 and MG &amp;lt; 20\u2005mmHg, were assessed in 883 individuals from the DANCAVAS screening study with aortic valve calcification and 257 individuals form the PROGRESSA study excluding those with left ventricular (LV) ejection fraction &amp;lt; 50%. In the DANCAVAS cohort, 150 men had mild\/moderate AS of which 34% had discordance between MG and AVA, representing 66% with moderate AS. Among 262 patients in the combined cohort, 39% had discordant LG-moderate AS and 6% discordant HG-mild AS. Compared with concordant mild and moderate AS, individuals with discordant LG-moderate AS were more likely to present with LV concentric remodelling geometry (26 vs. 33 vs. 45%, P &amp;lt; 0.001), increased valvulo-arterial impedance (3.3 \u00b1 0.7 vs. 3.6 \u00b1 0.5 vs. 4.1 \u00b1 0.7\u2005mmHg\/mL\/m2, P &amp;lt; 0.001), and reduced systemic arterial compliance (SAC) (0.74 \u00b1 0.22 vs. 0.81 \u00b1 0.22 vs. 0.64 \u00b1 0.18\u2005mL\/m2\/mmHg, P &amp;lt; 0.001). Factors associated with SV index were relative wall thickness, LV end-diastolic diameter index, SAC, and LV remodelling pattern.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Discordant moderate AS is common, accounting for two-thirds of patients with moderate AS in the general male population. Patients with discordant LG-moderate AS have predominantly a concentric remodelling pattern with reduced SV. Reduced SV index was associated with signs of reduced vascular compliance, suggesting that altered vascular properties drive differences in remodelling patterns and discordant moderate AS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf021","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:52:32Z","timestamp":1740138752000},"page":"686-694","source":"Crossref","is-referenced-by-count":1,"title":["Impact of valvulo-vascular haemodynamics on left ventricular remodelling and the prevalence of discordant moderate aortic stenosis"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2855-1713","authenticated-orcid":false,"given":"Mulham","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , J.B. Winsl\u00f8ws Vej 4, Odense 5000 ,","place":["Denmark"]},{"name":"Research Unit of Cardiology, Department of Clinical Research, University of Southern Denmark , Odense 5000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6374-5398","authenticated-orcid":false,"given":"Lionel","family":"Tastet","sequence":"additional","affiliation":[{"name":"Department of Medicine, Qu\u00e9bec Heart and Lung Institute, Laval University , Qu\u00e9bec ,","place":["Canada"]},{"name":"Division of Cardiovascular Medicine, University of California , San Francisco, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils Sofus Borg","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , J.B. Winsl\u00f8ws Vej 4, Odense 5000 ,","place":["Denmark"]},{"name":"Research Unit of Cardiology, Department of Clinical Research, University of Southern Denmark , Odense 5000 ,","place":["Denmark"]},{"name":"Department of Medicine, Qu\u00e9bec Heart and Lung Institute, Laval University , Qu\u00e9bec ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-4826","authenticated-orcid":false,"given":"Axel","family":"Diederichsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , J.B. Winsl\u00f8ws Vej 4, Odense 5000 ,","place":["Denmark"]},{"name":"Research Unit of Cardiology, Department of Clinical Research, University of Southern Denmark , Odense 5000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myl\u00e8ne","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Qu\u00e9bec Heart and Lung Institute, Laval University , Qu\u00e9bec ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Department of Medicine, Qu\u00e9bec Heart and Lung Institute, Laval University , Qu\u00e9bec ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-5845","authenticated-orcid":false,"given":"Jacob Eifer","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Research Unit of Cardiology, Department of Clinical Research, University of Southern Denmark , Odense 5000 ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-5446","authenticated-orcid":false,"given":"Kristian Altern","family":"\u00d8vrehus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , J.B. Winsl\u00f8ws Vej 4, Odense 5000 ,","place":["Denmark"]},{"name":"Research Unit of Cardiology, Department of Clinical Research, University of Southern Denmark , Odense 5000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-2835","authenticated-orcid":false,"given":"Elisabeth","family":"B\u00e9dard","sequence":"additional","affiliation":[{"name":"Department of Medicine, Qu\u00e9bec Heart and Lung Institute, Laval University , Qu\u00e9bec ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-4488","authenticated-orcid":false,"given":"Jes Sanddal","family":"Lindholt","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, and Vascular Surgery, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-9981","authenticated-orcid":false,"given":"Jess","family":"Lambrechtsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , Svendborg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0252-6631","authenticated-orcid":false,"given":"Flemming Hald","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lillebaelt Hospital, Vejle ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-7503","authenticated-orcid":false,"given":"Grazina","family":"Urbonaviciene","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Diagnostic Center, Regional Hospital, Silkeborg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5747-6839","authenticated-orcid":false,"given":"Amal","family":"Haujir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , J.B. 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