{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:18:49Z","timestamp":1794485929175,"version":"4.9.1"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["202203PJT-183888"],"award-info":[{"award-number":["202203PJT-183888"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001805","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001805","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015668","name":"Ministry of Research and Innovation, Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Myocardial work assessment has emerged as a promising tool for left ventricular (LV) performance evaluation. Existing non-invasive methods for assessing it rely on assumptions on LV pressure and geometry. Recently, shear wave elastography allowed to quantify changes in myocardial stiffness throughout the cardiac cycle. Based on Hooke\u2019s law, it becomes theoretically possible to calculate myocardial stress and work from myocardial stiffness and strain measurements. The main objective of this study is to demonstrate the feasibility of this comprehensive ultrasound approach and to compare myocardial work values between populations where variations are anticipated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Children with hypertrophic cardiomyopathy (HCM), aortic stenosis (AS) and healthy volunteers (HV) were included in this study. Segment dimensions, strain, thickness, and segmental myocardial stiffness were assessed in the basal antero-septal segment throughout the cardiac cycle. One-beat segmental work, the stress\u2013strain loop area, and contributive and dissipative work were compared between groups. Twenty HV (9.8 \u00b1 5.3 years of age), 20 HCM (10.0 \u00b1 6.1 years of age), and 5 AS (5.3 \u00b1 4.3 years of age) subjects were included. One-beat segmental work was significantly higher in AS (272.0 \u00b1 102.9 \u00b5J\/mm) and lower in HCM (38.2 \u00b1 106.9 \u00b5J\/mm) compared with HV (131.1 \u00b1 83.3 \u00b5J\/mm), P = 0.02 and P = 0.01, respectively. Desynchronized work was prevailing in HCM with dissipative work during systole measured at 17.3 \u00b1 28.9 \u00b5J\/mm and contributive work during diastole measured at 15.3 \u00b1 18.0 \u00b5J\/mm. The stress\u2013strain loop area was higher in AS (95.2 \u00b1 31.1 kPa%) and HV (66.2 \u00b1 35.9 kPa%) than in HCM (5.8 \u00b1 13.0 kPa%), P &amp;lt; 0.01.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Calculating segmental myocardial work based on myocardial stiffness and strain measurements is technically feasible. This approach overcomes the inherent limitations of current methods by introducing a direct quantitative measure of myocardial stress.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf089","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T20:15:26Z","timestamp":1741983326000},"page":"1051-1064","source":"Crossref","is-referenced-by-count":9,"title":["Towards non-invasive assessment of myocardial work using myocardial stiffness and strain: a human pilot study"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0889-1016","authenticated-orcid":false,"given":"Maelys","family":"Venet","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 170 Elizabeth St, University of Toronto , Toronto, ON M5G 1E8, Ontario ,","place":["Canada"]},{"name":"Ted Rogers Centre for Heart Research , 170 Elizabeth St, Toronto, ON M5G 1E8 ,","place":["Canada"]},{"name":"Department of Pediatric and Adult Congenital Cardiology, Bordeaux University Hospital (CHU) , 1 avenue Magellan - 33600 Pessac ,","place":["France"]},{"name":"Electrophysiology and Heart Modeling Institute, Institut Hospital-Universitaire Liryc, Fondation Bordeaux Universit\u00e9 , Av. du Haut L\u00e9v\u00eaque, 33600 Pessac ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Baranger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 170 Elizabeth St, University of Toronto , Toronto, ON M5G 1E8, Ontario ,","place":["Canada"]},{"name":"Ted Rogers Centre for Heart Research , 170 Elizabeth St, Toronto, ON M5G 1E8 ,","place":["Canada"]},{"name":"Physics for Medicine Paris, INSERM U1273, ESPCI Paris, CNRS FRE, PSL Research University , Paris 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[Internet]"},{"key":"2025053012434971500_jeaf089-B64","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ehjci\/jey131","article-title":"A new approach to assess myocardial work by non-invasive left ventricular pressure\u2013strain relations in hypertension and dilated cardiomyopathy","volume":"20","author":"Chan","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging [Internet]"},{"key":"2025053012434971500_jeaf089-B65","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.echo.2023.07.002","article-title":"State-of-the-art: noninvasive assessment of left ventricular function through myocardial work","volume":"36","author":"Moya","year":"2023","journal-title":"J Am Soc Echocardiography. 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