{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T09:35:08Z","timestamp":1794044108642,"version":"4.8.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The homogeneity of coronary microvascular dysfunction (CMD) across different myocardial territories in angina with non-obstructive coronary artery disease (ANOCA) patients is scarcely explored. This study investigates the variability in microvascular resistance reserve (MRR) across the 3 main perfusion territories of the coronary circulation to investigate the homogeneity or dishomogeneity of microcirculatory function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This post hoc analysis of the PACIFIC trials included symptomatic ANOCA patients with [15O]H2O positron emission tomography (PET) and three-vessel invasive fractional flow reserve (FFR). MRR was computed in the three main coronary branches by integrating PET-derived coronary flow reserve and invasive FFR. A total of 155 patients (50% male, age 59 \u00b1 10 years) and 465 vessels (MRR: 3.92 \u00b1 1.21) were included. There were no significant differences in MRR among the three coronary branches. Correlations in MRR among the three coronary branches were good (r = 0.76 to 0.86). The mean difference between MRR measurements in different arteries was small (2.4 to 7.5%), without any consistent directional bias. The overall intra-class correlation coefficient for absolute agreement was 0.80 (95% CI: 0.74\u20130.85), indicating good single-measure reliability. Approximately 80% (123\/155) of patients showed diagnostic concordance of CMD (MRR \u22643.0) across the three vessels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In most ANOCA patients, microvascular function is homogeneously distributed across the three major coronary territories. Single-artery testing may suffice in many cases, aligning with guidelines. However, some patients exhibit notable inter-territorial variation, suggesting that multi-vessel evaluation may be prudent in borderline scenarios.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf101","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T04:47:31Z","timestamp":1743223651000},"page":"1120-1127","source":"Crossref","is-referenced-by-count":9,"title":["Homogeneity of the coronary microcirculation in angina with non-obstructive coronary artery disease"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-1914","authenticated-orcid":false,"given":"Masahiro","family":"Hoshino","sequence":"first","affiliation":[{"name":"Departments of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081 HV Amsterdam ,","place":["The 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Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Twisk","sequence":"additional","affiliation":[{"name":"Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Danad","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081 HV Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Cardiology, University Medical Center Utrecht , Heidelberglaan 100, 3584 CX Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-5292","authenticated-orcid":false,"given":"Tsunekazu","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tsuchiura Kyodo General Hospital , Ibaraki 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