{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:30:13Z","timestamp":1792895413296,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Institutional funds of G. Monasterio CNR-Tuscany Foundation"},{"DOI":"10.13039\/501100007514","name":"University of Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Arrhythmic risk stratification in patients with non-ischaemic dilated cardiomyopathy (DCM) remains challenging. The LGE-dispersion mapping is a novel method for the quantification of tissue heterogeneity through the Global Dispersion Score (GDS). We sought to evaluate the usefulness of GDS in arrhythmic risk stratification of DCM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Consecutive non-ischaemic DCM patients underwent cardiac magnetic resonance imaging. GDS was calculated in LGE images. During a follow-up of 3.3 years (2 to 6 years), the combined endpoint of sudden cardiac death and appropriate implantable cardioverter-defibrillator intervention was considered. The final population included 510 patients (mean age was 56 \u00b1 15 years). Left ventricular ejection fraction (LVEF) was &amp;gt;35% in 241 patients (47%). LGE was present in 225 patients (45%). Median extent of LGE was 12% of LV mass [interquartile range (IQR) 6\u201320%]. Among patients with positive LGE, GDS was 0.14 (IQR 0.08\u20130.20). During follow-up 81 patients had malignant ventricular arrhythmias (8 SCD, 73 appropriate ICD interventions). At Kaplan\u2013Meier analysis, patients with GDS &amp;gt; 0.10 had worse prognosis than those with lower values of GDS (P &amp;lt; 0.0001). At multivariate analysis, GDS &amp;gt; 0.10 (HR 2.9, 95% CI: 1.7\u20135, P = 0.0002) was an independent predictor of events. The prognostic value of GDS was confirmed in subgroups of patients with LVEF \u2264 35% and &amp;gt;35%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GDS is a useful marker to identify DCM patients at higher risk for malignant arrhythmic events regardless of LVEF and extent of LGE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf124","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:24:44Z","timestamp":1744867484000},"page":"1217-1232","source":"Crossref","is-referenced-by-count":8,"title":["Late gadolinium enhancement dispersion for predicting malignant arrhythmic events in patient with non-ischaemic dilated cardiomyopathy"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-915X","authenticated-orcid":false,"given":"Giovanni Donato","family":"Aquaro","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and of critical area, Academic Radiology Unit, University of Pisa , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-3131","authenticated-orcid":false,"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Barison","sequence":"additional","affiliation":[{"name":"Fondazione Toscana G. Monasterio , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Luca","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Restivo","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste , Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3185-9240","authenticated-orcid":false,"given":"Roberto","family":"Licordari","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina , Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Todiere","sequence":"additional","affiliation":[{"name":"Fondazione Toscana G. 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Monasterio , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5262-4489","authenticated-orcid":false,"given":"Lorenzo","family":"Faggioni","sequence":"additional","affiliation":[{"name":"Department of Translational Research and of New technology, Academic Radiology Unit, University of Pisa , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Cioni","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and of critical area, Academic Radiology Unit, University of Pisa , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-9884","authenticated-orcid":false,"given":"Gianluca","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina , Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Lencioni","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and of critical area, Academic Radiology Unit, University of Pisa , Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-1962","authenticated-orcid":false,"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[{"name":"Fondazione Toscana G. 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