{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:23Z","timestamp":1793831243449,"version":"4.6.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Finnish Ministry of Social Affairs and Health","id":[{"id":"https:\/\/ror.org\/050p9zb50","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Paediatric Research Center"},{"name":"Helsinki University Hospital","id":[{"id":"https:\/\/ror.org\/02e8hzf44","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005744","name":"Foundation for Paediatric Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008969","name":"Alfred Kordelin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"The Finnish Foundation for Cardiovascular Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiac magnetic resonance (CMR) presents a promising non-invasive method for evaluating acute rejection in heart transplant recipients. As indicators of myocardial injury, T1 and T2 mapping values are crucial for comprehending rejection patterns in heart transplants. This study aims to define CMR T1 and T2 mapping values in heart transplant patients both with and without acute rejection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this blinded prospective study, we analysed CMR data from 244 scans of 58 paediatric and adult heart transplant recipients, 1\u201324 months post-transplant. Rejection status was defined by endomyocardial biopsy, clinical data, and donor-derived cell-free DNA (dd-cfDNA). Over the 24 months post-transplant, global T1 and T2 values decreased significantly (T1: \u03b2 = \u22128.9\/log(month), P &amp;lt; 0.001; T2: \u03b2 = \u22120.5\/log(month), P &amp;lt; 0.001) demonstrating the gradual recovery from transplant-related myocardial injury. During acute rejection, T1 values significantly increased compared to rejection-free studies in both children [estimates at 1 month post-transplant 1188\u2005ms (95% CI: 1161\u20131215) vs. 1079 ms (95% CI: 1061\u20131097), P &amp;lt; 0.001] and adults [1087\u2005ms (95% CI: 1045\u20131129) vs. 1016 ms (95% CI: 1005\u20131027), P = 0.007]. T1 and T2 values were positively associated with dd-cfDNA (P &amp;lt; 0.001 and P = 0.014, respectively), and T2 values with worse left ventricular global longitudinal strain (P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We provide essential T1 and T2 mapping values across cardiac segments, as well as left ventricular myocardial strain, both with and without acute rejection. These findings establish a reliable foundation for non-invasive heart transplant rejection screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT04311346<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf145","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:06:23Z","timestamp":1746777983000},"page":"1420-1428","source":"Crossref","is-referenced-by-count":15,"title":["Cardiac magnetic resonance in heart transplant recipients: histological, clinical and cell-free DNA validation"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9050-1516","authenticated-orcid":false,"given":"Marko A","family":"Taipale","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Pediatric Research Center, New Children\u2019s Hospital, University of Helsinki and Helsinki University Hospital , PO Box 281, Stenb\u00e4ckinkatu 11, Helsinki FI-00029 HUS ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku O","family":"Pentik\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A","family":"Martelius","sequence":"additional","affiliation":[{"name":"Department of Radiology, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino","family":"Mutka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soili I","family":"Kyt\u00f6l\u00e4","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, HUS Diagnostic Center, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Kankainen","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, HUS Diagnostic Center, Helsinki and Uusimaa Hospital District, Hematology Research Unit Helsinki, Translational Immunology Research Program, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha I","family":"Peltonen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simo O","family":"Syrj\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arttu J I","family":"Lahtiharju","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyri J","family":"Lommi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo J","family":"Jahnukainen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Transplantation, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl B","family":"Lemstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina H","family":"Ojala","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Pediatric Research Center, New Children\u2019s Hospital, University of Helsinki and Helsinki University Hospital , PO Box 281, Stenb\u00e4ckinkatu 11, Helsinki FI-00029 HUS 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