{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:59:27Z","timestamp":1792511967299,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","award":["FF22097"],"award-info":[{"award-number":["FF22097"]}],"id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pericoronary adipose tissue (PCAT) attenuation is a novel imaging biomarker of coronary inflammation associated with an increased risk of coronary artery disease (CAD). However, no studies have examined the relationship between chronic stress and PCAT. This study aimed to evaluate the intersection between chronic stress, inflammatory biomarkers, coronary plaque features, and PCAT attenuation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 98 participants without known CAD were included. PCAT attenuation, total plaque volume (TPV) quantification, and vulnerable plaque features were assessed by coronary CT angiography and chronic stress was measured by hair cortisol concentration (HCC) and vital exhaustion questionnaire. Regression models were used to analyse associations of PCAT with the inflammatory biomarkers interleukin-6 (IL-6) and tumour necrosis factor-\u03b1 (TNF-\u03b1), TPV, vulnerable plaque features, and coronary stenosis. Moderating analyses were performed to test whether chronic stress modulated the association between inflammatory biomarkers and PCAT attenuation. PCAT attenuation was significantly associated with IL-6 (mean difference 1.05, 95% CI 0.21\u20131.89, P = 0.014), TNF-\u03b1 (mean difference 0.60, 95% CI 0.06\u20131.13, P = 0.027), and a greater TPV (mean difference 3.51, 95% CI 0.02\u20137.00, P = 0.048), but not vulnerable plaque features or coronary stenosis. HCC (interaction term \u22120.12, 95% CI \u22120.22 to \u22120.02, P = 0.019) and vital exhaustion (interaction term 0.13, 95% CI 0.01\u20130.25, P = 0.024) moderated the relationship between IL-6, but not TNF-\u03b1, and PCAT attenuation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study suggests that circulating inflammatory biomarkers are associated with PCAT attenuation, which was further correlated with TPV. Chronic stress may moderate the relationship between inflammatory cytokines and PCAT attenuation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf217","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:43:25Z","timestamp":1753443805000},"page":"1664-1672","source":"Crossref","is-referenced-by-count":11,"title":["Association between inflammatory biomarkers, chronic stress, and pericoronary adipose tissue attenuation obtained with coronary CT"],"prefix":"10.1093","volume":"26","author":[{"given":"Tobia","family":"Albertini","sequence":"first","affiliation":[{"name":"Cardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"D\u00f6rner","sequence":"additional","affiliation":[{"name":"Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association , Magdeburg 39120 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas A","family":"Giannopoulos","sequence":"additional","affiliation":[{"name":"Cardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-5129","authenticated-orcid":false,"given":"Roland","family":"von K\u00e4nel","sequence":"additional","affiliation":[{"name":"Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-726X","authenticated-orcid":false,"given":"Dominik C","family":"Benz","sequence":"additional","affiliation":[{"name":"Cardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidaa","family":"Mikail","sequence":"additional","affiliation":[{"name":"Cardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]},{"name":"Center for Molecular Cardiology, University of Zurich , Schlieren 8952 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"de Wilde","sequence":"additional","affiliation":[{"name":"Cardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa D","family":"Voegel","sequence":"additional","affiliation":[{"name":"Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich , Zurich 8006 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina M","family":"Binz","sequence":"additional","affiliation":[{"name":"Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich , Zurich 8006 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-5210","authenticated-orcid":false,"given":"Philipp A","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Cardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gebhard","sequence":"additional","affiliation":[{"name":"Cardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 ,","place":["Switzerland"]},{"name":"Center for Molecular Cardiology, University of Zurich , Schlieren 8952 ,","place":["Switzerland"]},{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern , Bern 3010 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-8904","authenticated-orcid":false,"given":"Ronny R","family":"Buechel","sequence":"additional","affiliation":[{"name":"Cardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich , Zurich 8091 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