{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:28:51Z","timestamp":1793114931797,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Data are scarce regarding the implications of left atrial (LA) strain (LAS) in patients undergoing transcatheter edge-to-edge repair (TEER) for degenerative mitral regurgitation (MR). We explored pre-, intra-, and post-procedural aspects according to LAS status in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A single-centre, retrospective analysis was performed that included 367 individuals (median age 82 years, 62.4% male) referred to isolated, first-time interventions. Stratified by median LAS at baseline (18.5%) and at 1-month post-procedure (29.0%), the cohort was evaluated for all-cause mortality, heart failure (HF) hospitalizations, and significant MR and\/or functional incapacitation persistence during the first post-interventional year. Subjects with below-median preprocedural LAS presented more often with acute HF and\/or haemodynamic instability, displayed higher interventional risk and atrial fibrillation\/flutter prevalence, and had more pronounced chamber dysfunction\/dilatation. Procedural features were unaffected by baseline LAS allocation, leading to &amp;gt;97% technical success rate and &amp;gt;80% freedom from above-moderate MR or New York Heart Association Class III\u2013IV in both groups. Worse baseline LAS was associated with higher rates, cumulative incidences, and risks of deaths and\/or HF hospitalizations. Per exploratory analysis, the excess composite risk (hazard ratio 2.16, 95% confidence interval 1.16\u20134.00, P = 0.015) was confined to stable, chronic HF cases with significant LA dilatation. One-month post-procedural LAS directly correlated with its baseline counterpart, and a more impaired value\u2014rather than the change in LAS\u2014conferred heightened deaths\/HF readmissions risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although unrelated to procedural feasibility, safety, or efficacy, worse LAS identifies higher-risk patients prone to experience a less favourable clinical course post-TEER for degenerative MR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf267","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:54:07Z","timestamp":1757591647000},"page":"859-869","source":"Crossref","is-referenced-by-count":3,"title":["Correlates and prognostic value of left atrial strain in transcatheter edge-to-edge repair for degenerative mitral regurgitation"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9670-4026","authenticated-orcid":false,"given":"Alon","family":"Shechter","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"Department of Cardiology, Rabin Medical Center , 39 Jabotinsky St, Petach Tikva 4941492 ,","place":["Israel"]},{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University , 35 Klatzkin St, Tel Aviv 6997801 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Taheri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danon","family":"Kaewkes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University , Nai Muang ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagasaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine , Maebashi, Gunma ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Suruga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakriti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-3531","authenticated-orcid":false,"given":"Vivek","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Koren","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Koseki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabah","family":"Skaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moody","family":"Makar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhairya","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-2662","authenticated-orcid":false,"given":"Tarun","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]},{"name":"David Geffen School of Medicine, University of California Los Angeles , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj R","family":"Makkar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd A3100, Los Angeles, CA 90048 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"2026032620565434400_jeaf267-B1","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"77","author":"Writing Committee Members","year":"2021","journal-title":"J Am Coll 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