{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:16:00Z","timestamp":1789643760881,"version":"4.0.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Novel echocardiographic indices of right ventricular myocardial work (RVMW) are gaining ground for the evaluation of pulmonary arterial hypertension (PAH). However, their role in predicting haemodynamics and risk profile remains unclear. This study aimed to assess whether RVMW indices can identify patients at high risk for mortality and those with a worse haemodynamic profile as determined by right heart catheterization (RHC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with PAH, confirmed by RHC, with available echocardiographic images for RVMW estimation were analysed. Patients\u2019 risk profile was determined according to guidelines. RVMW indices were measured and correlated with four RHC parameters [mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), stroke volume index (SVI), pulmonary arterial compliance (PAC)]. RVMW analysis was completed in 58 PAH patients (58 \u00b1 14 years old, 72% female). RV global wasted work (RVGWW) was significantly increased, while RV global work efficiency was significantly decreased in the \u2018high risk\u2019 group. RVGWW correlated with mPAP (R = 0.46; P &amp;lt; 0.001), PVR (R = 0.51; P &amp;lt; 0.001), SVI (R = \u22120.3; P = 0.024), and PAC (R = \u22120.31; P = 0.02). Specific cut-off values of RVGWW emerged as predictors of worse haemodynamics based on spline curves; &amp;lt;60\u2005mmHg % indicated low-probability of PVR &amp;gt; 5\u2005WU, &amp;gt;83\u201384\u2005mmHg % indicated high probability of PAC &amp;lt; 2.3\u2005mL\/mmHg and mPAP &amp;gt; 40\u2005mmHg, and &amp;gt;120\u2005mmHg % indicated SVI &amp;lt; 31\u2005mL\/m2 in RHC. Furthermore, RVGWW values &amp;gt; 175\u2005mmHg % were associated with patients at high risk for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RVGWW correlated well with invasive haemodynamic parameters and was found to predict a worse haemodynamic and high-risk profile in a prospective cohort of PAH patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf272","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:42:14Z","timestamp":1757763734000},"page":"1855-1863","source":"Crossref","is-referenced-by-count":8,"title":["Echocardiographic right-ventricular global wasted work predicts haemodynamics and risk profile in pulmonary arterial hypertension"],"prefix":"10.1093","volume":"26","author":[{"given":"Christos","family":"Feloukidis","sequence":"first","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4427-8904","authenticated-orcid":false,"given":"Diamantis","family":"Kosmidis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-7280","authenticated-orcid":false,"given":"Alexandra","family":"Arvanitaki","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology, Ippokrateio General Hospital, Aristotle University of Thessaloniki , Konstantinoupoleos 49, Thessaloniki ,","place":["Greece"]},{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Arterial Hypertension, Royal Brompton Hospital, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , London SW3 6NP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Anastasiou","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas S","family":"Papazoglou","sequence":"additional","affiliation":[{"name":"Athens Naval Hospital , Mesogeion Avenue 229, Cholargos, Athens 15561 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Chrysochoidis-Trantas","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia-Anastasia","family":"Mouratoglou","sequence":"additional","affiliation":[{"name":"Third Department of Cardiology, Ippokration Hospital, Aristotle University of Thessaloniki , Thessaloniki ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-0602","authenticated-orcid":false,"given":"Matthaios","family":"Didagelos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Grosomanidis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Ziakas","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Giannakoulas","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-6718","authenticated-orcid":false,"given":"Vasileios","family":"Kamperidis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , St. Kiriakidi 1, Thessaloniki, GR 54636 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