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The prevalence of AVC increases with age, but the impact of age on the progression of AVC and its association with moderate-severe AS is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Our study included 6810 participants (52.9% women) without overt cardiovascular disease between ages 45 and 84 from the Multi-Ethnic Study of Atherosclerosis. AVC was measured using non-contrast cardiac CT at Visit 1. Progression was calculated as the change in AVC divided by years between CT scans (2\u201310 years). Incident moderate-severe AS was adjudicated using medical chart review and echocardiogram data from Visit 6 (median follow-up of 16 years). The association between AVC and moderate-severe AS was assessed using multivariable adjusted Cox proportional hazards ratios. There were 5899 participants with AVC = 0 and 911 with AVC &amp;gt;0. There were 3834 participants age &amp;lt;65 years and 2979 age \u226565 years. The median AVC was 34.1 AU (IQR 13\u20131113) for participants &amp;lt;65 vs. 69.0 AU (IQR 23\u20132453) for participants \u226565. Participants &amp;lt;65 and \u226565 years had no significant difference in median annualized AVC progression within the baseline AVC categories of 1\u201399 (10 vs. 12 AU\/year, P = 0.303) and AVC \u2265100 (50 vs. 47 AU\/year, P = 0.846). AVC &amp;gt;0 was associated with a similar significantly higher risk of incident moderate-severe AS for both younger (HR 13.37; 95% CI 5.67\u201331.52) and older participants (HR 10.59, 95% CI 6.77\u201316.56).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AVC progression was significantly associated with baseline AVC burden and was similar for younger vs. older persons after accounting for baseline AVC. The presence of AVC was significantly associated with a higher long-term risk for moderate-severe AS among both younger and older participants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf279","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:54:51Z","timestamp":1758369291000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Impact of age on aortic valve calcium progression and risk for aortic stenosis: multi-ethnic study of atherosclerosis"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1938-9679","authenticated-orcid":false,"given":"Natalie","family":"Marrero","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Miami , Miami, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Jha","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Louisville , 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J","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome I","family":"Rotter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-ULCA Medical Center , Torrance, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine , 600 North Wolfe Street, Blalock 524A, Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-5204","authenticated-orcid":false,"given":"Wendy S","family":"Post","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine , 600 North Wolfe Street, Blalock 524A, Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslee J","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology), Blavatnik Family Research Institute, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Thanassoulis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Preventive and Genomic Cardiology, McGill University and the McGill University Health Center Research Institute , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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