{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:54:04Z","timestamp":1789620844683,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"NIHR Research","doi-asserted-by":"publisher","award":["NIHR201460"],"award-info":[{"award-number":["NIHR201460"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Clinician Scientist","award":["CS-2018\u201318-ST2\u2013007"],"award-info":[{"award-number":["CS-2018\u201318-ST2\u2013007"]}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","award":["RP-2017-08-ST2-007"],"award-info":[{"award-number":["RP-2017-08-ST2-007"]}],"id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UP_1605\/13"],"award-info":[{"award-number":["MC_UP_1605\/13"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/F\/24\/110138"],"award-info":[{"award-number":["RG\/F\/24\/110138"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/24\/130023"],"award-info":[{"award-number":["RE\/24\/130023"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/P\/23\/80008"],"award-info":[{"award-number":["CH\/P\/23\/80008"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In patients with suspected coronary artery disease (CAD), the role of adenosine-stress cardiovascular magnetic resonance (CMR) is well established. However, to meet increasing demand, improving its time efficiency and cost-effectiveness is critical. Recent advances in accelerated, free-breathing cine and scar imaging now enable accelerated stress\u2013perfusion protocols. This study evaluated whether an accelerated, stress-only perfusion protocol achieves non-inferior diagnostic accuracy compared with a standard stress\u2013rest perfusion CMR protocol for detecting significant CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with suspected angina referred for invasive coronary angiography (ICA) underwent two 3-Tesla CMR scans (standard and accelerated protocols), on separate days in randomized order. Significant CAD was defined as fractional flow reserve (FFR) \u2264 0.80 in epicardial vessels \u22652\u2005mm diameter (or quantitative flow ratio \u22640.80 if FFR unavailable). CMR images were evaluated qualitatively with (i) primary per-vessel analysis (determined by two independent readers) and (ii) secondary per-patient analysis (following consensus read). Of 167 prospectively recruited patients, 150 completed both CMR protocols and ICA (mean age 66 \u00b1 10 years, 71% male, CAD prevalence 51%). The accelerated scan was better tolerated by patients, with scan duration 19 \u00b1 5\u2005min (24\u2005min shorter than the standard protocol [95% CI: 23, 25], P &amp;lt; 0.001). Compared with standard CMR, accelerated CMR achieved non-inferior per-vessel diagnostic accuracy at a pre-specified 5% non-inferiority margin (+0.7% [\u22122.7%, 4.0%], pnon-inferiority = 0.001 and +3.4% [\u22120.1%, 6.8%], pnon-inferiority &amp;lt; 0.001 for the two readers). Accelerated CMR also achieved comparable per-patient accuracy (+4.6% [\u22121.5%, 11.0%], P = 0.189 for consensus read; accuracy 88.6%, sensitivity 84.2%, and specificity 93.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared to standard stress\u2013perfusion CMR, an accelerated stress\u2013perfusion protocol achieves non-inferior diagnostic accuracy at the vessel level, with a time saving of over 20\u2005min per scan. Accelerated imaging may prove effective in the clinical arena to evaluate patients with suspected angina.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf322","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:08:02Z","timestamp":1763557682000},"page":"597-607","source":"Crossref","is-referenced-by-count":1,"title":["Accelerated stress CMR for the detection of significant coronary artery disease: a prospective randomized diagnostic accuracy study"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8555-5141","authenticated-orcid":false,"given":"Mohamed","family":"Elshibly","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4761-7297","authenticated-orcid":false,"given":"Simran","family":"Shergill","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Velvet","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Gohar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals of Leicester NHS Trust , Leicester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyansh","family":"Pattani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals of Leicester NHS Trust , Leicester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly S","family":"Parke","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"England","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Moafi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]},{"name":"Department of Cardiology, University Hospitals of Leicester NHS Trust , Leicester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan P","family":"O\u2019Regan","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory of Medical Sciences, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Wu","sequence":"additional","affiliation":[{"name":"Health Economics and Health Technology Assessment, School of Health and Wellbeing, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Adlam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-6070","authenticated-orcid":false,"given":"Peter","family":"Kellman","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-8647","authenticated-orcid":false,"given":"Alasdair","family":"McIntosh","sequence":"additional","affiliation":[{"name":"School of Health and Wellbeing, Robertson Centre for Biostatistics, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-7000","authenticated-orcid":false,"given":"Alex","family":"McConnachie","sequence":"additional","affiliation":[{"name":"School of Health and Wellbeing, Robertson Centre for Biostatistics, University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-0594","authenticated-orcid":false,"given":"Andrew","family":"Ladwiniec","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester, LE3 9QP ,","place":["UK"]},{"name":"Department of Cardiology, University Hospitals of Leicester NHS Trust , Leicester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry P","family":"McCann","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, The National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation 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