{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:38:11Z","timestamp":1793039891192,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0501400"],"award-info":[{"award-number":["2021YFF0501400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0501404"],"award-info":[{"award-number":["2021YFF0501404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of National Natural Science Foundation of China","award":["82430066"],"award-info":[{"award-number":["82430066"]}]},{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"publisher","award":["Z-2014-07-2101"],"award-info":[{"award-number":["Z-2014-07-2101"]}],"id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The prognostic value of late gadolinium enhancement (LGE) phenotypes-particularly subendocardial involvement-for sudden cardiac death (SCD) remains unclear in dilated cardiomyopathy (DCM). Whether LGE phenotype integrating pattern and location can improve SCD risk stratification is an unmet need.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>DCM patients who underwent cardiac MRI were retrospectively enrolled. The endpoint was a composite of SCD and surrogate SCD events. Among 902 patients (mean age 46 \u00b1 14 years, 78.7% men), subendocardium-involved and mid-wall LGE were observed in 129 (14.3%) and 263 (29.1%) patients, predominantly involving the lateral (65.1%) and septal wall (97.7%), respectively. During a median follow-up of 77 months (IQR 40\u201392 months), 51 (5.7%) patients experienced SCD events. Multivariable analysis identified septal mid-wall LGE (HR 3.59; 95% CI 1.73\u20137.47; P = 0.001) and lateral subendocardium-involved LGE (HR 3.07; 95% CI 1.39\u20136.75; P = 0.005) as independent predictors. A three-tier risk stratification model was developed, classifying patients into: lowest risk (neither septal mid-wall nor lateral subendocardium-involved LGE; reference), intermediate risk (either phenotype alone; HR 4.8, 95% CI 2.2\u201310.46, P &amp;lt; 0.001), and highest risk (both phenotypes; HR 10.71, 95% CI 3.53\u201332.46, P &amp;lt; 0.001). The model showed the best improvement in model discrimination and reclassification over left ventricular ejection fraction (C-statistic improvement: 0.23; net reclassification improvement = 0.67; integrative discrimination index = 0.27; all P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SCD was predicted by both lateral subendocardium-involved LGE and septal mid-wall LGE in DCM. The novel SCD risk model integrating these phenotypes demonstrated superior prognostic performance compared with conventional prognosticators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeaf376","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:27:27Z","timestamp":1767443247000},"page":"662-675","source":"Crossref","is-referenced-by-count":1,"title":["Subendocardium-involved late gadolinium enhancement in non-ischemic dilated cardiomyopathy improves risk stratification of sudden cardiac death"],"prefix":"10.1093","volume":"27","author":[{"given":"Xi","family":"Jia","sequence":"first","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kankan","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of 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