{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:31:38Z","timestamp":1793413898662,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize sex-specific patterns of bicuspid aortic valve (BAV) valvulo-aortopathy using consensus phenotyping and to assess how aortic normalization strategies influence sex-related differences in aortic dimensions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed 808 adults with BAV (mean age 49.9 \u00b1 17.5 years; 588 men) from the RE-BAV registry. Valve morphology, aortopathy phenotypes, and clinical valvulo-aortopathy categories were classified according to consensus definitions. Typical and uncomplicated forms were additionally analysed together as a non-complex category. Proximal aortic dimensions were defined as the aortic root and ascending aorta.<\/jats:p>\n                    <jats:p>Valve morphology distribution did not differ by sex. Although the prevalence of aortic dilatation was similar, phenotype distribution differed: women more frequently exhibited the extended phenotype (34.7% vs. 23.3%, P = 0.001), whereas the root phenotype was more common in men (15.1% vs. 7.8%, P = 0.006). Moderate-to-severe aortic regurgitation was more prevalent in men (50.3% vs. 29.1%, P &amp;lt; 0.001). Sex differences in proximal aortic dimensions varied by normalization strategy. For the ascending aorta, indexing to body surface area yielded larger values in women (21.1 \u00b1 4.0 vs. 20.0 \u00b1 4.0 mm\/m\u00b2, P = 0.001), whereas diameter\/height showed no sex-related difference at this level. Conversely, the cross-sectional area-to-height ratio remained higher in men across proximal segments, most prominently at the sinuses of Valsalva (6.9 \u00b1 2.0 vs. 5.6 \u00b1 1.6 cm\u00b2\/m, P &amp;lt; 0.001). Age was independently associated with larger proximal aortic dimensions across all strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sex-related differences in BAV involved aortopathy phenotype, aortic regurgitation burden, and proximal aortic dimensions. Interpretation of proximal aortic dimensions depended on the normalization strategy used, indicating that indexing methods should not be treated as interchangeable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jeag233","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:15:39Z","timestamp":1788156939000},"page":"1926-1936","source":"Crossref","is-referenced-by-count":0,"title":["Sex-specific patterns of valvulo-aortopathy in bicuspid aortic valve according to the international consensus framework: insights from the RE-BAV registry"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-3261","authenticated-orcid":false,"given":"Edyta","family":"P\u0142o\u0144ska-Go\u015bciniak","sequence":"first","affiliation":[{"name":"Department of Cardiology, Pomeranian Medical University , Powsta\u0144c\u00f3w Wlkp. 72, Szczecin 70-111 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-8201","authenticated-orcid":false,"given":"Wojciech","family":"Kosmala","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Imaging, Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University , Borowska 213, Wroclaw 50-556 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8484-0899","authenticated-orcid":false,"given":"Jerzy","family":"Pacholewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Pomeranian Medical University , Powsta\u0144c\u00f3w Wlkp. 72, Szczecin 70-111 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Wojciechowska","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Specialist Hospital Zabrze , Marii Curie-Sk\u0142odowskiej 10, Zabrze 41-800 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-5109","authenticated-orcid":false,"given":"Ilona","family":"Kowalik","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Clinical Research Support Center, , Alpejska 42, Warszawa 04-628 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-3320","authenticated-orcid":false,"given":"Bo\u017cena","family":"Sobkowicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Bialystok , Marii Sk\u0142odowskiej-Curie 24a, Bia\u0142ystok 15-276 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-9038","authenticated-orcid":false,"given":"Tomasz","family":"Hirnle","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Bia\u0142ystok , M. Sk\u0142odowskiej-Curie 24a, Bia\u0142ystok 15-276 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5338-9652","authenticated-orcid":false,"given":"Andrzej","family":"Tomaszewski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Lublin , Jaczewskiego 8, 20-090 Lublin ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-8371","authenticated-orcid":false,"given":"Beata","family":"Zaborska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital , Grenadier\u00f3w 51\/59, 04-073 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-4825","authenticated-orcid":false,"given":"Maria","family":"Binkiewicz-Orluk","sequence":"additional","affiliation":[{"name":"Chair and Department of Cardiology, Hypertension and Internal Medicine, Medical University of Warsaw , Mazowiecki Szpital Br\u00f3dnowski, Kondratowicza 8, 03-258 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-7001","authenticated-orcid":false,"given":"Andrzej","family":"Szyszka","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Pozna\u0144 University of Medical Sciences , 28 Czerwca 1956 r, nr 194, Pozna\u0144 61-485 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-886X","authenticated-orcid":false,"given":"Tomasz","family":"Hryniewiecki","sequence":"additional","affiliation":[{"name":"Department of Valvular Heart Disease, National Institute of Cardiology , Alpejska 42, Warszawa 04-628 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-6234","authenticated-orcid":false,"given":"Julia","family":"Grapsa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Brigham and Women\u2019s Hospital, Harvard Medical School , 75 Francis St, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-278X","authenticated-orcid":false,"given":"Frank A","family":"Flachskampf","sequence":"additional","affiliation":[{"name":"Dept. 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