{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:02:52Z","timestamp":1790474572118,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"European Association of Cardiovascular Imaging Research Grant"},{"name":"Greek State Scholarships Foundation"},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/ehjci\/jey107","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T07:08:46Z","timestamp":1531552126000},"page":"426-437","source":"Crossref","is-referenced-by-count":34,"title":["Relation of regional myocardial structure and function in hypertrophic cardiomyopathy and amyloidois: a combined two-dimensional speckle tracking and cardiovascular magnetic resonance analysis"],"prefix":"10.1093","volume":"20","author":[{"given":"Efstathios D","family":"Pagourelias","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital Leuven, Catholic University Leuven, Herestraat 49, Leuven, Belgium"},{"name":"Third Cardiology Department, Hippokrateion University Hospital, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Str, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Mirea","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital Leuven, Catholic University Leuven, Herestraat 49, Leuven, Belgium"},{"name":"Department of Cardiology, University of Medicine and Pharmacy of Craiova, University County Hospital of Craiova, 1 Tabaci Str, Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Vovas","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Leuven, Catholic University Leuven, Herestraat 49, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Duchenne","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital Leuven, Catholic University Leuven, Herestraat 49, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blazej","family":"Michalski","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital Leuven, Catholic University Leuven, Herestraat 49, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van Cleemput","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital Leuven, Catholic University Leuven, Herestraat 49, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bogaert","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Leuven, Catholic University Leuven, Herestraat 49, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios P","family":"Vassilikos","sequence":"additional","affiliation":[{"name":"Third Cardiology Department, Hippokrateion University Hospital, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Str, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Uwe","family":"Voigt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital Leuven, Catholic University Leuven, Herestraat 49, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"key\n\t\t\t\t2019032204593902300_jey107-B1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0140-6736(12)60397-3","article-title":"Hypertrophic cardiomyopathy","volume":"381","author":"Maron","year":"2013","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CRD.0000000000000048","article-title":"Feasibility and significance of preclinical diagnosis in hypertrophic cardiomyopathy","volume":"23","author":"Efthimiadis","year":"2014","journal-title":"Cardiol Rev"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/CIRCIMAGING.110.958751","article-title":"Heterogeneity of intramural function in hypertrophic cardiomyopathy: mechanistic insights from MRI late gadolinium enhancement and high-resolution displacement encoding with stimulated echoes strain maps","volume":"4","author":"Aletras","year":"2011","journal-title":"Circ Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.echo.2015.03.010","article-title":"Impact of global and segmental hypertrophy on two-dimensional strain derived from three-dimensional echocardiography in hypertrophic cardiomyopathy: comparison with healthy subjects","volume":"28","author":"Voilliot","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCIMAGING.113.000842","article-title":"Investigation of global and regional myocardial mechanics with 3-dimensional speckle tracking echocardiography and relations to hypertrophy and fibrosis in hypertrophic cardiomyopathy","volume":"7","author":"Urbano-Moral","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B6","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1161\/01.CIR.0000150334.69355.00","article-title":"Discrimination of nonobstructive hypertrophic cardiomyopathy from hypertensive left ventricular hypertrophy on the basis of strain rate imaging by tissue Doppler ultrasonography","volume":"110","author":"Kato","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B7","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.echo.2010.06.006","article-title":"Hypertrophy pattern and regional myocardial mechanics are related in septal and apical hypertrophic cardiomyopathy","volume":"23","author":"Yang","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B8","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jacc.2005.10.061","article-title":"Global and regional myocardial function quantification by two dimensional strain: application in hypertrophic cardiomyopathy","volume":"47","author":"Serri","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B9","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1016\/j.ijcard.2013.06.105","article-title":"Regional peak longitudinal-strain by 2D speckle-tracking TTE provides useful information to distinguish fibrotic from non-fibrotic lesions in LV myocardium on cardiac MR in hypertrophic cardiomyopathy","volume":"168","author":"Funabashi","year":"2013","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B10","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/mrm.10543","article-title":"Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging","volume":"50","author":"Ennis","year":"2003","journal-title":"Magn Reson Med"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B11","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1136\/heartjnl-2012-302353","article-title":"Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis","volume":"98","author":"Phelan","year":"2012","journal-title":"Heart"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B12","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCIMAGING.113.000683","article-title":"Effect of combined systolic and diastolic functional parameter assessment for differentiation of cardiac amyloidosis from other causes of concentric left ventricular hypertrophy","volume":"6","author":"Liu","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B13","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B15","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/ehjci\/jew082","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"17","author":"Nagueh","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjci\/jeu184","article-title":"Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to Standardize Deformation Imaging","volume":"16","author":"Voigt","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jcmg.2014.10.010","article-title":"How to define end-diastole and end-systole?: impact of timing on strain measurements","volume":"8","author":"Mada","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.echo.2012.10.005","article-title":"Current state of three-dimensional myocardial strain estimation using echocardiography","volume":"26","author":"Jasaityte","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/01.CIR.65.1.99","article-title":"Noninvasive determination of left ventricular end-systolic stress: validation of the method and initial application","volume":"65","author":"Reichek","year":"1982","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B20","doi-asserted-by":"crossref","first-page":"e005588","DOI":"10.1161\/CIRCIMAGING.116.005588","article-title":"Echo parameters for differential diagnosis in cardiac amyloidosis: a head-to-head comparison of deformation and nondeformation parameters","volume":"10","author":"Pagourelias","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/13506129.2017.1333956","article-title":"Diagnostic score for the detection of cardiac amyloidosis in patients with left ventricular hypertrophy and impact on prognosis","volume":"24","author":"Cariou","year":"2017","journal-title":"Amyloid"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmg.2013.08.015","article-title":"CMR-based differentiation of AL and ATTR cardiac amyloidosis","volume":"7","author":"Dungu","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang","year":"1986","journal-title":"Biometrika"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/aje\/kwf215","article-title":"Statistical analysis of correlated data using generalized estimating equations: an orientation","volume":"157","author":"Hanley","year":"2003","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B25","doi-asserted-by":"crossref","first-page":"13429","DOI":"10.1073\/pnas.93.23.13429","article-title":"Bootstrap confidence levels for phylogenetic trees","volume":"93","author":"Efron","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B26","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jcmg.2015.11.013","article-title":"The relation of ejection fraction and global longitudinal strain in amyloidosis: implications for differential diagnosis","volume":"9","author":"Pagourelias","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B27","first-page":"5","article-title":"The relative impact of circumferential and longitudinal shortening on left ventricular ejection fraction and stroke volume","volume":"17","author":"Maciver","year":"2012","journal-title":"Exp Clin Cardiol"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B28","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2017.06.046","article-title":"Geometry as a confounder when assessing ventricular systolic function: comparison between ejection fraction and strain","volume":"70","author":"Stokke","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jcmg.2008.02.006","article-title":"Twist mechanics of the left ventricle: principles and application","volume":"1","author":"Sengupta","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jcmg.2015.05.014","article-title":"Causes and consequences of longitudinal LV dysfunction assessed by 2D strain echocardiography in cardiac amyloidosis","volume":"9","author":"Ternacle","year":"2016","journal-title":"J Am Coll Cardiol Img"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B31","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jcmg.2012.05.009","article-title":"LV segmentation and mechanics in HCM: twisting the Rubik's Cube into perfection!","volume":"5","author":"Sengupta","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B32","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1007\/s10439-010-0031-5","article-title":"Resolving myoarchitectural disarray in the mouse ventricular wall with diffusion spectrum magnetic resonance imaging","volume":"38","author":"Wang","year":"2010","journal-title":"Ann Biomed Eng"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B33","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.mri.2006.12.008","article-title":"Study of myocardial fiber pathway using magnetic resonance diffusion tensor imaging","volume":"25","author":"Wu","year":"2007","journal-title":"Magn Reson Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B34","doi-asserted-by":"crossref","first-page":"378.","DOI":"10.1007\/s00395-013-0378-5","article-title":"Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity","volume":"108","author":"Guan","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B35","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.echo.2008.09.011","article-title":"Association between regional ventricular function and myocardial fibrosis in hypertrophic cardiomyopathy assessed by speckle tracking echocardiography and delayed hyperenhancement magnetic resonance imaging","volume":"21","author":"Popovi\u0107","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B36","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.echo.2015.06.011","article-title":"Head-to-head comparison of global longitudinal strain measurements among nine different vendors: the EACVI\/ASE Inter-Vendor Comparison Study","volume":"28","author":"Farsalinos","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jcmg.2017.01.027","article-title":". Variability and reproducibility of segmental longitudinal strain measurement: a report from the EACVI-ASE strain standardization task force","volume":"11","author":"Mirea","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2019032204593902300_jey107-B38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jcmg.2017.02.014","article-title":"Intervendor differences in the accuracy of detecting regional functional abnormalities: a report from the EACVI-ASE strain standardization task force","volume":"11","author":"Mirea","year":"2018","journal-title":"J Am Coll Cardiol Img"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/20\/4\/426\/28170873\/jey107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T05:00:29Z","timestamp":1553230829000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/20\/4\/426\/5063544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,8,1]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jey107","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2018,8,1]]}}}