{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:32:23Z","timestamp":1767832343890,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Academy of Finland Centre of Excellence on Cardiovascular and Metabolic Diseases"},{"DOI":"10.13039\/501100005633","name":"Finnish Foundation for Cardiovascular Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011797","name":"Turku University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011797","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academy of Finland and the Finnish Foundation for Cardiovascular Research"},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Abbot"},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Lilly","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Recurrent chest pain after coronary artery bypass grafting (CABG) poses a diagnostic challenge. We hypothesized that combining anatomy of bypass grafts and native coronary arteries with ischaemia detection by hybrid imaging could be used to gain valuable and complementary information in patients with recurrent symptoms after CABG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We analysed 36 consecutive patients (67\u2009\u00b1\u20099\u2009years, 81% male) who had undergone hybrid imaging using coronary computed tomography angiography (CCTA) and [15O]H2O positron emission tomography (PET) myocardial perfusion imaging due to recurrent symptoms after CABG. Coronary tree and left ventricular myocardium were divided into three main territories, yielding a total of 108 coronary territories in 36 patients. The presence of obstructive (\u226550%) stenosis and the patency of grafts were evaluated by CCTA, while myocardial ischaemia was assessed by quantitative adenosine-stress PET. Altogether 28 (78%) of the 36 study patients presented with matched PET\/CCTA abnormalities. Forty-one coronary territories were supplied by non-obstructed bypass grafts or native coronary arteries (protected territory). However, 12 (29%) of these presented with a perfusion defect. In six cases, the perfusion defect involved myocardium distal to the graft-coronary anastomosis, as interpreted on the PET\/CCTA fusion images. In turn, in 48 coronary territories the supplying artery was obstructed on CCTA (unprotected territory). Of these, 41 (85%, P\u2009&lt;\u20090.001 vs. protected) presented with abnormal perfusion, involving myocardium distal to the anastomosis in 29 cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Hybrid imaging provides complementary information on the presence and localization of atherosclerotic lesions and myocardial perfusion abnormalities in symptomatic patients with previous CABG.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jey160","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T15:39:16Z","timestamp":1538667556000},"page":"1298-1304","source":"Crossref","is-referenced-by-count":16,"title":["Hybrid coronary computed tomography angiography and positron emission tomography myocardial perfusion imaging in evaluation of recurrent symptoms after coronary artery bypass grafting"],"prefix":"10.1093","volume":"20","author":[{"given":"Teemu","family":"Maaniitty","sequence":"first","affiliation":[{"name":"Turku PET Centre, University of Turku, Kiinamyllynkatu 4\u20138, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuli","family":"Jaakkola","sequence":"additional","affiliation":[{"name":"Heart Center, Turku University Hospital and University of Turku, H\u00e4meentie 11, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Saraste","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Kiinamyllynkatu 4\u20138, Turku, Finland"},{"name":"Heart Center, Turku University Hospital and University of Turku, H\u00e4meentie 11, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhani","family":"Knuuti","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Kiinamyllynkatu 4\u20138, Turku, Finland"},{"name":"Department of Clinical physiology, nuclear medicine and PET, Turku University Hospital, H\u00e4meentie 11, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"2019102305491222500_jey160-B1","first-page":"2541","article-title":"ESC\/EACTS Guidelines on myocardial revascularization: the task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"35","author":"Windecker","year":"2014","journal-title":"Eur Heart J"},{"key":"2019102305491222500_jey160-B2","first-page":"e652","article-title":"ACCF\/AHA Guideline for coronary artery bypass graft surgery: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"124","author":"Hillis","year":"2011","journal-title":"Circulation"},{"key":"2019102305491222500_jey160-B3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0735-1097(95)00280-4","article-title":"Recurrence of angina after coronary artery bypass surgery: predictors and prognosis (CASS Registry). 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