{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:46:32Z","timestamp":1782377192128,"version":"3.54.5"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pulmonary regurgitation (PR) and right ventricular (RV) dilatation are common in repaired tetralogy of Fallot (rTOF). Left ventricular (LV) dysfunction is an important risk factor in rTOF. The effect of PR\/RV dilatation on LV performance and RV-LV interactions in rTOF are incompletely understood. We examined LV responses and exercise capacity in rTOF, both before and after pulmonary valve replacement (PVR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Cardiac magnetic resonance imaging scans in 126 rTOF patients (age 17.3\u2009\u00b1\u20097.6 years) were analysed, comparing subjects with indexed RV end-diastolic volume (RVEDVi) &lt;170\u2009mL\/m2 (mild\/moderate dilatation, n\u2009=\u200995) and RVEDVi \u2265170\u2009mL\/m2 (severe dilatation, n\u2009=\u200931). Indexed PR volume (PRVi), RV end-systolic (RVESVi), RV end-diastolic (RVEDVi), RV stroke volume (RVSVi), net pulmonary forward flow (NPFFi), LV end-diastolic (LVEDVi), LV end-systolic (LVESVi), LV stroke volume (LVSVi), RV and LV ejection fraction (EF), and diastolic septal curvature were obtained. Peak aerobic capacity (VO2 max) was measured. In a subset (n\u2009=\u200930), measures were obtained pre-and-post surgical PVR. Compared to those with mild\/moderate RV dilatation, patients with severe RV dilation had greater PRVi (38\u2009\u00b1\u200912 vs. 24\u2009\u00b1\u20099\u2009mL\/m2, P\u2009&lt;\u20090.0001), NPFFi (53\u2009\u00b1\u20099 vs. 44\u2009\u00b1\u200911\u2009mL\/m2, P\u2009&lt;\u20090.0001), LVEDVi (87\u2009\u00b1\u200914 vs. 73\u2009\u00b1\u200913\u2009mL\/m2, P\u2009&lt;\u20090.0001), LVESVi (39\u2009\u00b1\u200912 vs. 30\u2009\u00b1\u20098\u2009mL\/m2, P\u2009&lt;\u20090.0001), and LVSVi (48\u2009\u00b1\u20097 vs. 43\u2009\u2009\u00b1\u2009\u20098\u2009mL\/m2, P\u2009=\u20090.002) but lower RV ejection fraction (46\u2009\u00b1\u20098 vs. 53\u2009\u00b1\u20097%, P\u2009&lt;\u20090.0001). Septal curvature and VO2 max were similar in both groups. After PVR, there was no change in LVEDVi, LVSVi, septal curvature, or VO2 max.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Chronic PR with severe RV dilatation is associated with increased NPFFi, LVEDVi, and LVSVi. This may potentially explain preserved exercise capacity in rTOF with severe PR and RV dilatation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jez035","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T12:44:13Z","timestamp":1550493853000},"page":"1020-1026","source":"Crossref","is-referenced-by-count":12,"title":["Severe right ventricular dilatation after repair of Tetralogy of Fallot is associated with increased left ventricular preload and stroke volume"],"prefix":"10.1093","volume":"20","author":[{"given":"Ganesh Kumar","family":"Gnanappa","sequence":"first","affiliation":[{"name":"The Heart Centre for Children, The Children\u2019s Hospital at Westmead, Corner of Hawkesbury Road and Hainsworth Street, Westmead, New South Wales 2145, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Celermajer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales 2050, Australia"},{"name":"Sydney Medical School, The University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Technology, University of Sydney, Maze Crescent, Darlington, New South Wales 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Puranik","sequence":"additional","affiliation":[{"name":"The Heart Centre for Children, The Children\u2019s Hospital at Westmead, Corner of Hawkesbury Road and Hainsworth Street, Westmead, New South Wales 2145, Australia"},{"name":"Department of Cardiology, The Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales 2050, Australia"},{"name":"Sydney Medical School, The University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Ayer","sequence":"additional","affiliation":[{"name":"The Heart Centre for Children, The Children\u2019s Hospital at Westmead, Corner of Hawkesbury Road and Hainsworth Street, Westmead, New South Wales 2145, Australia"},{"name":"Sydney Medical School, The University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"2019091011510497500_jez035-B1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0140-6736(00)02714-8","article-title":"Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre 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