{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T12:59:39Z","timestamp":1775048379508,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Gottfried and Julia Bangerter-Rhyner-Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate valve sizing and the haemodynamic relevance of the predicted left ventricular outflow tract (LVOT) in patients with mitral annular calcification (MAC) undergoing transatrial transcatheter valve implantation (THV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In total, 21 patients undergoing transatrial THV, multiplanar reconstruction (MPR), maximum intensity projection (MIP), and cubic spline interpolation (CSI) were compared for MA sizing during diastole. In addition, predicted neo-LVOT areas were measured in 18 patients and correlated with the post-procedural haemodynamic dimensions. The procedure was successful in all patients (100%). Concomitant aortic valve replacement was performed in eight patients (43%) (AVR group). Sizing using MPR and MIP yielded comparable results in terms of area, perimeter, and diameter, whereas the dimensions obtained with CSI were systematically smaller. The simulated mean systolic neo-LVOT area was 133.4\u2009\u00b1\u200964.2\u2009mm2 with an anticipated relative LVOT area reduction (neo-LVOT area\/LVOT area \u00d7 100) of 59.3\u2009\u00b1\u200914.7%. The systolic relative LVOT area reduction, but not the absolute neo-LVOT area, was found to predict the peak (r\u2009=\u20090.69; P\u2009=\u20090.002) and mean (r\u2009=\u20090.65; P\u2009=\u20090.004) post-operative aortic gradient in the overall population as well as separately in the AVR (peak: r\u2009=\u20090.91; P\u2009=\u20090.002\/mean: r\u2009=\u20090.85; P\u2009=\u20090.002) and no-AVR (peak: r\u2009=\u20090.89; P\u2009=\u20090.003\/mean: r\u2009=\u20090.72; P\u2009=\u20090.008) groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with severe MAC undergoing transatrial transcatheter valve implantation, MPR, and MIP yielded comparable annular dimensions, while values obtained with CSI tended to be systematically smaller. Mitral annular area and the average annular diameter appear to be reliable parameters for valve selection. Simulated relative LVOT reduction was found to predict the post-procedural aortic gradients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jez050","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T20:59:05Z","timestamp":1551905945000},"page":"1395-1406","source":"Crossref","is-referenced-by-count":15,"title":["Imaging in patients with severe mitral annular calcification: insights from a multicentre experience using transatrial balloon-expandable valve replacement"],"prefix":"10.1093","volume":"20","author":[{"given":"Fabien","family":"Praz","sequence":"first","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar K","family":"Khalique","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Cardiovascular Thoracic Institute, University of Southern California, Santa Monica, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac Y","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyde","family":"Russell","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Evanston Hospital Northshore University HealthSystem, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic Hospital, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dee Dee","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Henry Ford Hospital Center for Structural Heart Disease, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Veeragandham","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, John Muir Health Care, Concord, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashequl M","family":"Islam","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Baystate Medical Center, Springfield, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W","family":"Deaton","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Baystate Medical Center, Springfield, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle W","family":"Eudailey","sequence":"additional","affiliation":[{"name":"Princeton Baptist Medical Center, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Akkoc","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Kantor","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane C H","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joongheum S","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamim M","family":"Nazif","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten P","family":"Vahl","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca T","family":"Hahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susheel K","family":"Kodali","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Takayama","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinayak","family":"Bapat","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, Columbia University Medical Center, MHB 7GN-435, 177 Ft Washington Ave, New York, NY 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Borger","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"George","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York-Presbyterian Hospital, 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of the anterior mitral leaflet to prevent outflow obstruction during transcatheter mitral valve replacement: first-in-human experience","volume":"10","author":"Babaliaros","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"2019112104003286000_jez050-B4","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.4244\/EIJ-D-17-00742","article-title":"Alcohol septal ablation preceding transcatheter valve implantation to prevent left ventricular outflow tract obstruction","volume":"13","author":"Sayah","year":"2018","journal-title":"EuroIntervention"},{"key":"2019112104003286000_jez050-B5","first-page":"382","article-title":"Surgical antegrade transcatheter mitral valve implantation for symptomatic mitral valve disease and heavily calcified annulus","volume":"51","author":"Langhammer","year":"2017","journal-title":"Eur J Cardiothorac 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