{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:09:01Z","timestamp":1775768941370,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Herlev & Gentofte Hospital"},{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The ratio of early mitral inflow velocity to global diastolic strain rate (E\/e\u2032sr) has recently emerged as a novel measure of left ventricular filling pressure. E\/e\u2032sr has in previous studies demonstrated to have good prognostic value in various patient populations. The aim of this study is to investigate the prognostic value of E\/e\u2032sr in a large cohort of patients with Type 2 diabetes in relation to cardiovascular morbidity and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In this prospective study, 848 Type 2 diabetic patients (mean age 63.6 \u00b1 10.3 years, 64.7% male) underwent comprehensive echocardiographic examination including 2D speckle tracking in which E\/e\u2032sr along with novel and conventional echocardiographic variables were obtained. During follow-up (median: 4.8 years, interquartile range: 4.0\u20135.3), 122 (14.1%) met the composite outcome of cardiovascular disease, hospitalization, and mortality. Both E\/e\u2032sr and E\/e\u2032 were significantly associated with the outcome [E\/e\u2032sr: hazard ratio (HR) 1.07, 95% confidence interval (CI): 1.05\u20131.10; P &lt; 0.001, per 0.10 m increase] and (E\/e\u2032: HR 1.07, 95% CI: 1.05\u20131.10; P = 0.001, per 1 unit increase). E\/e\u2032sr remained an independent predictor after multivariable adjustment for demographical, clinical, and echocardiographic parameters (HR 1.06, 95% CI: 1.01\u20131.12; P = 0.032, per 10 cm increase). The same was true for E\/e\u2032 (HR 1.09, 95% CI: 1.04\u20131.14; P &lt; 0.001, per 1 unit increase). Additionally, E\/e\u2032sr provided incremental prognostic information beyond the UK \u2018Prospective Diabetes Study risk engine\u2019 0.72 (0.68\u20130.77) vs. 0.74 (0.70\u201379), P = 0.040.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with Type 2 diabetes, E\/e\u2032sr provides independent and incremental prognostic information regarding cardiovascular morbidity and mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jez075","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T16:12:28Z","timestamp":1553789548000},"page":"1171-1178","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic value of ratio of transmitral early filling velocity to early diastolic strain rate in patients with Type 2 diabetes"],"prefix":"10.1093","volume":"20","author":[{"given":"Mats Christian H\u00f8jbjerg","family":"Lassen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, DK Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus T","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, DK Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, DK Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus","family":"M\u00f8gelvang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, DK Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fritz-Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, DK Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Copenhagen, Niels Steensens vej 2, Gentofte, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, K\u00f8benhavn N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, Copenhagen, Niels Steensens vej 2, Gentofte, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, K\u00f8benhavn N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Godsk","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens vej 65, DK Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"2019092004513214800_jez075-B1","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1161\/CIRCULATIONAHA.108.829176","article-title":"Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005","volume":"119","author":"Preis","year":"2009","journal-title":"Circulation"},{"key":"2019092004513214800_jez075-B2","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1056\/NEJMoa1310799","article-title":"Changes in diabetes-related complications in the United States, 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