{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:53:10Z","timestamp":1792626790943,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We evaluated the relationship between epicardial adipose tissue (EAT) and coronary vascular function assessed by rubidium-82 (82Rb) positron emission tomography\/computed tomography (PET\/CT) in patients with suspected coronary artery disease (CAD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The study population included 270 patients with suspected CAD and normal myocardial perfusion at stress\u2013rest 82Rb PET\/CT. Coronary artery calcium (CAC) score and EAT volume were measured. Absolute myocardial blood flow (MBF) was computed in mL\/min\/ from the dynamic rest and stress imaging. Myocardial perfusion reserve (MPR) was defined as the ratio of hyperaemic to baseline MBF and it was considered reduced when &lt;2. MPR was normal in 177 (65%) patients and reduced in 93 (35%). Patients with impaired MPR were older (P\u2009&lt;\u20090.001) and had higher CAC score values (P\u2009=\u20090.033), EAT thickness (P\u2009=\u20090.009), and EAT volume (P\u2009&lt;\u20090.001). At univariable logistic regression analysis, age, heart rate reserve (HRR), CAC score, EAT thickness, and EAT volume resulted significant predictors of reduced MPR, but only age (P\u2009=\u20090.002), HRR (P\u2009=\u20090.021), and EAT volume (P\u2009=\u20090.043) were independently associated with reduced MPR, at multivariable analysis. In patients with CAC score 0 (n\u2009=\u2009114), a significant relation between EAT volume and MPR (P\u2009=\u20090.014) was observed, while the relationship was not significant (P\u2009=\u20090.21) in patients with CAC score &gt;0 (n\u2009=\u2009156).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with suspected CAD and normal myocardial perfusion, EAT volume predicts hyperaemic MBF and reduced MPR, confirming that visceral pericardium fat may influence coronary vascular function. Thus, EAT evaluation has a potential role in the early identification of coronary vascular dysfunction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jez182","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T23:13:07Z","timestamp":1560985987000},"page":"1379-1387","source":"Crossref","is-referenced-by-count":39,"title":["Relationship between epicardial adipose tissue and coronary vascular function in patients with suspected coronary artery disease and normal myocardial perfusion imaging"],"prefix":"10.1093","volume":"20","author":[{"given":"Carmela","family":"Nappi","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ponsiglione","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Acampa","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"},{"name":"Institute of Biostructure and Bioimaging, National Council of Research, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Gaudieri","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Zampella","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Assante","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Cuocolo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Mannarino","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Dell\u2019Aversana","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Petretta","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Imbriaco","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3431-7658","authenticated-orcid":false,"given":"Alberto","family":"Cuocolo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Via Sergio Pansini 5, 80131 Napoli, 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