{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T10:26:34Z","timestamp":1770546394918,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Hokkaido University Hospital"},{"name":"Japan Heart Foundation & Astellas"},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["JP16K10264"],"award-info":[{"award-number":["JP16K10264"]}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Myocardial perfusion imaging without and with quantitative myocardial blood flow (MBF) and myocardial flow reserve (MFR) plays an important role in the diagnosis and risk stratification of patients with stable coronary artery disease (CAD). We aimed to quantify the effects of coronary revascularization on regional stress MBF and MFR and to determine whether the presence of subendocardial infarction was associated with these changes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Forty-seven patients with stable CAD were prospectively enrolled. They underwent 15O-water positron emission tomography at baseline and 6\u2009months after optimal medical therapy alone (n\u2009=\u200916), percutaneous coronary intervention (PCI) (n\u2009=\u200918), or coronary artery bypass grafting (CABG) (n\u2009=\u200913). Stenosis of \u226550% diameter was detected in 98\/141 vessels (70%). The regional MFR was significantly increased from baseline to follow-up [1.84 (interquartile range, IQR 1.28\u20132.17) vs. 2.12 (IQR 1.69\u20132.63), P\u2009&amp;lt;\u20090.001] in vessel territories following PCI or CABG due to an increase in the stress MBF [1.33 (IQR 0.97\u20131.67) mL\/g\/min vs. 1.64 (IQR 1.38\u20132.17) mL\/g\/min, P\u2009&amp;lt;\u20090.001], whereas there was no significant change in the regional stress MBF or MFR in vessel territories without revascularization. A multilevel mixed-effects models adjusted for baseline characteristics, subendocardial infarction assessed by cardiovascular magnetic resonance imaging, and intra-patient correlation showed that the degree of angiographic improvement after coronary revascularization was significantly associated with increased regional stress MBF and MFR (P\u2009&amp;lt;\u20090.05 for all).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Coronary revascularization improved the regional stress MBF and MFR in patients with stable CAD. The magnitude of these changes was associated with the extent of revascularization independent of subendocardial infarction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jez220","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T07:32:12Z","timestamp":1566027132000},"page":"36-46","source":"Crossref","is-referenced-by-count":19,"title":["Improved regional myocardial blood flow and flow reserve after coronary revascularization as assessed by serial 15O-water positron emission tomography\/computed tomography"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1786-0176","authenticated-orcid":false,"given":"Tadao","family":"Aikawa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan"},{"name":"Department of Minimally Invasive Advanced Heart Failure Therapeutics, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Naya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Koyanagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Magota","sequence":"additional","affiliation":[{"name":"Division of Medical Imaging and Technology, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Oyama-Manabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagara","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Anzai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"2019122003575063800_jez220-B1","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jacc.2014.05.069","article-title":"Quantitative assessment of myocardial perfusion in the detection of significant coronary artery disease: cutoff values and diagnostic accuracy of quantitative [15O]H2O PET imaging","volume":"64","author":"Danad","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2019122003575063800_jez220-B2","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1161\/CIRCULATIONAHA.111.050427","article-title":"Improved cardiac risk assessment with noninvasive measures of coronary flow reserve","volume":"124","author":"Murthy","year":"2011","journal-title":"Circulation"},{"key":"2019122003575063800_jez220-B3","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa070829","article-title":"Optimal medical therapy with or without PCI for stable coronary disease","volume":"356","author":"Boden","year":"2007","journal-title":"N Engl J Med"},{"key":"2019122003575063800_jez220-B4","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1056\/NEJMoa0805796","article-title":"A randomized trial of therapies for type 2 diabetes and coronary artery disease","volume":"360","author":"Frye","year":"2009","journal-title":"N Engl J Med"},{"key":"2019122003575063800_jez220-B5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2967\/jnumed.118.211953","article-title":"Regional, artery-specific thresholds of quantitative myocardial perfusion by PET associated with reduced myocardial infarction and death after revascularization in stable coronary artery disease","volume":"60","author":"Gould","year":"2019","journal-title":"J Nucl Med"},{"key":"2019122003575063800_jez220-B6","doi-asserted-by":"crossref","first-page":"e007417.","DOI":"10.1161\/CIRCIMAGING.117.007417","article-title":"Impact of revascularization on absolute myocardial blood flow as assessed by serial [15O]H2O positron emission tomography imaging: a comparison with fractional flow reserve","volume":"11","author":"Driessen","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"2019122003575063800_jez220-B7","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/s00259-019-04278-8","article-title":"The impact of revascularization on myocardial blood flow as assessed by positron emission tomography","volume":"46","author":"Bober","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2019122003575063800_jez220-B8","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJM200011163432003","article-title":"The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction","volume":"343","author":"Kim","year":"2000","journal-title":"N Engl J Med"},{"key":"2019122003575063800_jez220-B9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/cvr\/cvy169","article-title":"Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease","volume":"115","author":"Aikawa","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2019122003575063800_jez220-B10","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"2013 ESC guidelines on the management of stable coronary artery disease: the task force on the management of stable coronary artery disease of the European Society of Cardiology","volume":"34","author":"Montalescot","year":"2013","journal-title":"Eur Heart J"},{"key":"2019122003575063800_jez220-B11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"2019122003575063800_jez220-B12","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00259-017-3760-y","article-title":"Regional interaction between myocardial sympathetic denervation, contractile dysfunction, and fibrosis in heart failure with preserved ejection fraction: 11C-hydroxyephedrine PET study","volume":"44","author":"Aikawa","year":"2017","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2019122003575063800_jez220-B13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/01.CIR.63.2.285","article-title":"Coronary artery atherosclerosis: severity of the disease, severity of angina pectoris and compromised left ventricular function","volume":"63","author":"Leaman","year":"1981","journal-title":"Circulation"},{"key":"2019122003575063800_jez220-B14","first-page":"219\u201327.","article-title":"The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease","volume":"1","author":"Sianos","year":"2005","journal-title":"EuroIntervention"},{"key":"2019122003575063800_jez220-B15","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.4244\/EIJV8I11A196","article-title":"The CABG SYNTAX Score\u2014an angiographic tool to grade the complexity of coronary disease following coronary artery bypass graft surgery: from the SYNTAX Left Main Angiographic (SYNTAX-LE MANS) substudy","volume":"8","author":"Farooq","year":"2013","journal-title":"EuroIntervention"},{"key":"2019122003575063800_jez220-B16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jcmg.2016.09.019","article-title":"Routine clinical quantitative rest stress myocardial perfusion for managing coronary artery disease: clinical relevance of test-retest variability","volume":"10","author":"Kitkungvan","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"2019122003575063800_jez220-B17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/CIRCULATIONAHA.114.011939","article-title":"Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization","volume":"131","author":"Taqueti","year":"2015","journal-title":"Circulation"},{"key":"2019122003575063800_jez220-B18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7326\/0003-4819-118-2-199301150-00001","article-title":"Value of the history and physical in identifying patients at increased risk for coronary artery disease","volume":"118","author":"Pryor","year":"1993","journal-title":"Ann Intern Med"},{"key":"2019122003575063800_jez220-B19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCINTERVENTIONS.112.000064","article-title":"Residual ischemia after revascularization in multivessel coronary artery disease: insights from measurement of absolute myocardial blood flow using magnetic resonance imaging compared with angiographic assessment","volume":"6","author":"Arnold","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"key":"2019122003575063800_jez220-B20","doi-asserted-by":"crossref","first-page":"e001715.","DOI":"10.1161\/CIRCINTERVENTIONS.114.001715","article-title":"Change in coronary blood flow after percutaneous coronary intervention in relation to baseline lesion physiology: results of the JUSTIFY-PCI study","volume":"8","author":"Nijjer","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"2019122003575063800_jez220-B21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1161\/01.CIR.86.1.167","article-title":"A new strategy for the assessment of viable myocardium and regional myocardial blood flow using 15O-water and dynamic positron emission tomography","volume":"86","author":"Yamamoto","year":"1992","journal-title":"Circulation"},{"key":"2019122003575063800_jez220-B22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s12350-015-0329-7","article-title":"In vivo assessment of myocardial viability after acute myocardial infarction: a head-to-head comparison of the perfusable tissue index by PET and delayed contrast-enhanced CMR","volume":"24","author":"Timmer","year":"2017","journal-title":"J Nucl Cardiol"},{"key":"2019122003575063800_jez220-B23","doi-asserted-by":"crossref","first-page":"H2634","DOI":"10.1152\/ajpheart.2000.279.6.H2634","article-title":"Persistent but reversible coronary microvascular dysfunction after bypass grafting","volume":"279","author":"Spyrou","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2019122003575063800_jez220-B24","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1056\/NEJMra1406944","article-title":"Coronary-artery bypass grafting","volume":"374","author":"Alexander","year":"2016","journal-title":"N Engl J Med"},{"key":"2019122003575063800_jez220-B25","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1093\/eurheartj\/ehn045","article-title":"Physiological evaluation of the provisional side-branch intervention strategy for bifurcation lesions using fractional flow reserve","volume":"29","author":"Koo","year":"2008","journal-title":"Eur Heart J"},{"key":"2019122003575063800_jez220-B26","first-page":"970","article-title":"Quantitative myocardial perfusion by O-15-water PET: individualized vs. standardized vascular territories","volume":"16","author":"Thomassen","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/21\/1\/36\/31569829\/jez220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/21\/1\/36\/31569829\/jez220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T03:58:21Z","timestamp":1576814301000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/21\/1\/36\/5572612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,23]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,9,23]]},"published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jez220","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,9,23]]}}}