{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:37:41Z","timestamp":1773693461182,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Right ventricular free wall longitudinal strain (RVFWLS) has been proposed as an accurate and sensitive measure of right ventricular function that could integrate other conventional parameters such as tricuspid annulus plane systolic excursion (TAPSE) and fractional area change (FAC%). The aim of the present study was to evaluate the relationship between RVFWLS and outcomes in stable asymptomatic outpatients with left-sided structural heart disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We enrolled 458 asymptomatic patients with left-side heart diseases and any ejection fraction who were referred for echocardiography to two Italian centres. The composite endpoint of death for any cause and heart failure hospitalization was used as primary outcome of this analysis. After a mean follow-up of 5.4\u2009\u00b1\u20091.2\u2009years, 145 patients (31%) reached the combined endpoint. Most of echocardiographic parameters were related to outcomes, including right ventricular functional parameters. Mean value of RVFWLS in our cohort was \u221221 \u00b1 8% and it was significantly related to the combined endpoint and in multivariable Cox-regression model; when tested with other echocardiographic parameters that were significantly related to outcome at univariate analysis, RVFWLS maintained its independent association with outcome (hazard ratio 0.963, 95% confidence interval 0.948\u20130.978; P\u2009=\u20090.0001). The best cut-off value of RVFWLS to predict outcome was \u221222% (area under the curve 0.677; P\u2009&amp;lt;\u20090.001; sensitivity 70%; 65% specificity).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>RVFWLS may help clinicians to identify patients with left-sided structural heart disease at higher risk for first heart failure hospitalization and death for any cause.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jez246","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T11:37:32Z","timestamp":1569238652000},"page":"1013-1021","source":"Crossref","is-referenced-by-count":51,"title":["Prognostic value of right ventricular free wall longitudinal strain in a large cohort of outpatients with left-side heart disease"],"prefix":"10.1093","volume":"21","author":[{"given":"Mara","family":"Gavazzoni","sequence":"first","affiliation":[{"name":"Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, 25100 Brescia, Italy"},{"name":"Heart and Valve Center, University Heart Center of Z\u00fcrich, University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-3283","authenticated-orcid":false,"given":"Luigi P","family":"Badano","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto Auxologico Italiano, S. Luca Hospital, University of Milano-Bicocca, P.zza Brescia n 20, 20149, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Vizzardi","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, 25100 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Raddino","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, 25100 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-0969","authenticated-orcid":false,"given":"Davide","family":"Genovese","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, University of Padova School of Medicine, Nicolo Giustiniani Street, n 2, 35128, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"Heart and Valve Center, University Heart Center of Z\u00fcrich, University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Sciatti","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, 25100 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-5280","authenticated-orcid":false,"given":"Chiara","family":"Palermo","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, University of Padova School of Medicine, Nicolo Giustiniani Street, n 2, 35128, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, 25100 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-3668","authenticated-orcid":false,"given":"Denisa","family":"Muraru","sequence":"additional","affiliation":[{"name":"Heart and Valve Center, University Heart Center of Z\u00fcrich, University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland"},{"name":"IRCCS, Istituto Auxologico Italiano, S. 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