{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:23:59Z","timestamp":1792794239453,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["FP7-CP-FP506 2007"],"award-info":[{"award-number":["FP7-CP-FP506 2007"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["222915"],"award-info":[{"award-number":["222915"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EVINCI"},{"name":"Evaluation of Integrated Cardiac Imaging for the Detection and Characterisation of Ischemic Heart Disease"},{"name":"Centre of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research"},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Cardiovascular Biomedical Research Unit of Royal Brompton & Harefield NHS Foundation Trust","id":[{"id":"https:\/\/ror.org\/02218z997","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute for Health Research Cardiovascular Biomedical Research Unit at St Bartholomew\u2019s Hospital","id":[{"id":"https:\/\/ror.org\/0187kwz08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Science and Higher Education, Poland","id":[{"id":"https:\/\/ror.org\/05dwvd537","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cardiovascular Biomedical Research Unit at Barts"},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the prognostic relevance of coronary anatomy, coronary function, and early revascularization in patients with stable coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>From March 2009 to June 2012, 430 patients with suspected CAD (61\u2009\u00b1\u20099\u2009years, 62% men) underwent coronary anatomical imaging by computed tomography coronary angiography (CTCA) and coronary functional imaging followed by invasive coronary angiography (ICA) if at least one non-invasive test was abnormal. Obstructive CAD was documented by ICA in 119 patients and 90 were revascularized within 90\u2009days of enrolment. Core laboratory analysis showed that 134 patients had obstructive CAD by CTCA (&amp;gt;50% stenosis in major coronary vessels) and 79 significant ischaemia by functional imaging [&amp;gt;10% left ventricular (LV) myocardium]. Over mean follow-up of 4.4 years, major adverse events (AEs) (all-cause death, non-fatal myocardial infarction, or hospital admission for unstable angina or heart failure) or AEs plus late revascularization (LR) occurred in 40 (9.3%) and 58 (13.5%) patients, respectively. Obstructive CAD at CTCA was the only independent imaging predictor of AEs [hazard ratio (HR) 3.2, 95% confidence interval (CI) 1.10\u20139.30; P\u2009=\u20090.033] and AEs plus LR (HR 4.3, 95% CI 1.56\u201311.81; P\u2009=\u20090.005). Patients with CAD in whom early revascularization was performed in the presence of ischaemia and deferred in its absence had fewer AEs, similar to patients without CAD (HR 2.0, 95% CI 0.71\u20135.51; P\u2009=\u20090.195).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Obstructive CAD imaged by CTCA is an independent predictor of clinical outcome. Early management of CAD targeted to the combined anatomical and functional disease phenotype improves clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjci\/jez248","type":"journal-article","created":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T18:40:52Z","timestamp":1569782452000},"page":"1273-1282","source":"Crossref","is-referenced-by-count":45,"title":["Anatomical and functional coronary imaging to predict long-term outcome in patients with suspected coronary artery disease: the EVINCI-outcome study"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-9538","authenticated-orcid":false,"given":"Danilo","family":"Neglia","sequence":"first","affiliation":[{"name":"Cardiovascular Department, Fondazione Toscana G. Monasterio, Via G. Moruzzi 1, 56124 Pisa, Italy"},{"name":"CNR, Institute of Clinical Physiology, Via G. Moruzzi 1, 56124 Pisa, Italy"},{"name":"Sant\u2019Anna School of Advanced Studies, Piazza Martiri della Libert\u00e0, 33, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Liga","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Via Roma, 67, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Caselli","sequence":"additional","affiliation":[{"name":"CNR, Institute of Clinical Physiology, Via G. Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-7179","authenticated-orcid":false,"given":"Clara","family":"Carpeggiani","sequence":"additional","affiliation":[{"name":"CNR, Institute of Clinical Physiology, Via G. Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-0301","authenticated-orcid":false,"given":"Valentina","family":"Lorenzoni","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna School of Advanced Studies, Piazza Martiri della Libert\u00e0, 33, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3154-5102","authenticated-orcid":false,"given":"Rosa","family":"Sicari","sequence":"additional","affiliation":[{"name":"CNR, Institute of Clinical Physiology, Via G. Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Multimodality Cardiac Imaging Section, I.R.C.C.S. Policlinico San Donato, Piazza Edmondo Malan, 2, 20097 San Donato Milanese, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Gaemperli","sequence":"additional","affiliation":[{"name":"Cardiology, HeartClinic Hirslanden, Witellikerstrasse 40, 8032, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Cardiac Imaging, Nuclear Medicine Department, University Hospital Z\u00fcrich, R\u00e4mistrasse 100, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J H A","family":"Scholte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-1442","authenticated-orcid":false,"given":"S Richard","family":"Underwood","sequence":"additional","affiliation":[{"name":"Department of Non-Invasive Cardiac Imaging, Royal Brompton Hospital and Harefield Hospital, 250 King\u2019s Rd, Chelsea, London SW3 5UE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-9593","authenticated-orcid":false,"given":"Juhani","family":"Knuuti","sequence":"additional","affiliation":[{"name":"PET Center, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, 20521 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the EVINCI Study 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