{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:18:06Z","timestamp":1793582286379,"version":"4.5.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this study was to examine the potential usefulness and clinical relevance of a novel left atrial (LA) filling index using 2D speckle-tracking transthoracic echocardiography to estimate left ventricular (LV) filling pressures in patients with preserved LV ejection fraction (LVEF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The LA filling index was calculated as the ratio of the mitral early-diastolic inflow peak velocity (E) over LA reservoir strain (i.e. E\/LA strain ratio). This index showed a good diagnostic performance to determine elevated LV filling pressures in a test-cohort (n\u2009=\u200931) using invasive measurements of LV end-diastolic pressure (area under the curve 0.82, cut-off &amp;gt; 3.27\u2009=\u2009sensitivity 83.3%, specificity 78.9%), which was confirmed in a validation-cohort (patients with cardiovascular risk factors; n\u2009=\u2009486) using the 2016 American Society of Echocardiography\/European Association of Cardiovascular Imaging criteria (cut-off &amp;gt; 3.27\u2009=\u2009sensitivity 88.1%, specificity 77.6%) and in a specificity-validation cohort (patients free of cardiovascular risk factors, n\u2009=\u2009120; cut-off &amp;gt; 3.27\u2009=\u2009specificity 98.3%). Regarding the clinical relevance of the LA filling index, an elevated E\/LA strain ratio (&amp;gt;3.27) was significantly associated with the risk of heart failure hospitalization at 2 years (odds ratio 4.3, 95% confidence interval 1.8\u201310.5), even adjusting this analysis by age, sex, renal failure, LV hypertrophy, or abnormal LV global longitudinal systolic strain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The findings from this study suggest that a novel LA filling index using 2D speckle-tracking echocardiography could be of potential usefulness and clinical relevance in estimating LV filling pressures in patients with preserved LVEF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jez272","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T19:27:03Z","timestamp":1570562823000},"page":"260-269","source":"Crossref","is-referenced-by-count":32,"title":["Potential usefulness and clinical relevance of a novel left atrial filling index to estimate left ventricular filling pressures in patients with preserved left ventricular ejection fraction"],"prefix":"10.1093","volume":"21","author":[{"given":"Kerstin","family":"Braunauer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dirk","family":"D\u00fcngen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Belyavskiy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Aravind-Kumar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Frydas","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kropf","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiqiong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Marquez","sequence":"first","affiliation":[{"name":"Private Clinic of Radiology (Q-Diagnostica-Scanner Murcia), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Tadic","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Osmanoglou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Meoclinic, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Edelmann","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Tsch\u00f6pe","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif-Hendrik","family":"Boldt","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkert","family":"Pieske","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"},{"name":"Department of Internal Medicine and Cardiology, German Heart Center, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Pieske-Kraigher","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Morris","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 University Medicine Berlin - Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"2020022003592841500_jez272-B1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/ehjci\/jeu219","article-title":"Normal values and clinical relevance of left atrial myocardial function analysed by speckle-tracking echocardiography: multicentre study","volume":"16","author":"Morris","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2020022003592841500_jez272-B2","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.echo.2016.03.013","article-title":"Left atrial function in preclinical diastolic dysfunction: two-dimensional speckle-tracking echocardiography-derived results from the BEFRI trial","volume":"29","author":"Brecht","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"2020022003592841500_jez272-B3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jcmg.2016.08.014","article-title":"LA strain categorization of LV diastolic dysfunction","volume":"10","author":"Singh","year":"2017","journal-title":"J Am Coll Cardiol Img"},{"key":"2020022003592841500_jez272-B4","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.jcmg.2017.07.029","article-title":"Potential usefulness and clinical relevance of adding left atrial strain to left atrial volume index in the detection of left ventricular diastolic dysfunction","volume":"11","author":"Morris","year":"2018","journal-title":"J Am Coll Cardiol Img"},{"key":"2020022003592841500_jez272-B5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.echo.2009.04.026","article-title":"Correlation between left ventricular end-diastolic pressure and peak left atrial wall strain during left ventricular systole","volume":"22","author":"Wakami","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"2020022003592841500_jez272-B6","doi-asserted-by":"crossref","first-page":"14.","DOI":"10.1186\/1476-7120-8-14","article-title":"Left atrial longitudinal strain by speckle tracking echocardiography correlates well with left ventricular filling pressures in patients with heart failure","volume":"8","author":"Cameli","year":"2010","journal-title":"Cardiovasc Ultrasound"},{"key":"2020022003592841500_jez272-B7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/ejechocard\/jer283","article-title":"Relation of left ventricular end-diastolic pressure and N-terminal pro-brain natriuretic peptide level with left atrial deformation parameters","volume":"13","author":"Kurt","year":"2012","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2020022003592841500_jez272-B8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/echo.13094","article-title":"Correlation of left atrial strain and Doppler measurements with invasive measurement of left ventricular end-diastolic pressure in patients stratified for different values of ejection fraction","volume":"33","author":"Cameli","year":"2016","journal-title":"Echocardiography"},{"key":"2020022003592841500_jez272-B9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10741-016-9589-9","article-title":"Left atrium: the last bulwark before overt heart failure","volume":"22","author":"Cameli","year":"2017","journal-title":"Heart Fail Rev"},{"key":"2020022003592841500_jez272-B10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10741-015-9520-9","article-title":"Left atrial strain: a new parameter for assessment of left ventricular filling pressure","volume":"21","author":"Cameli","year":"2016","journal-title":"Heart Fail Rev"},{"key":"2020022003592841500_jez272-B11","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/ejhf.645","article-title":"Global left atrial failure in heart failure","volume":"18","author":"Triposkiadis","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2020022003592841500_jez272-B12","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1161\/CIRCHEARTFAILURE.114.001276","article-title":"Left atrium in heart failure with preserved ejection fraction: structure, function, and significance","volume":"7","author":"Rossi","year":"2014","journal-title":"Circ Heart Fail"},{"key":"2020022003592841500_jez272-B13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/ejechocard\/jep007","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography","volume":"10","author":"Nagueh","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"2020022003592841500_jez272-B14","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/ehjci\/jew082","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"17","author":"Nagueh","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2020022003592841500_jez272-B15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ejhf.971","article-title":"Non-invasive assessment of left ventricular filling pressure","volume":"20","author":"Nagueh","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2020022003592841500_jez272-B16","article-title":"Left ventricular diastolic function: understanding pathophysiology, diagnosis, and prognosis with echocardiography","author":"Nagueh","year":"2019","journal-title":"J Am Coll Cardiol Img"},{"key":"2020022003592841500_jez272-B17","first-page":"701","article-title":"Early detection of cardiac alterations by left atrial strain in patients with risk for cardiac abnormalities with preserved left ventricular systolic and diastolic function","volume":"34","author":"Braunauer","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"key":"2020022003592841500_jez272-B18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2020022003592841500_jez272-B19","doi-asserted-by":"crossref","first-page":"17318.","DOI":"10.1038\/srep17318","article-title":"Prognostic role of left atrial strain and its combination index with transmitral E-wave velocity in patients with atrial fibrillation","volume":"6","author":"Hsu","year":"2016","journal-title":"Sci Rep"},{"key":"2020022003592841500_jez272-B20","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/eurheartj\/ehm037","article-title":"How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology","volume":"28","author":"Paulus","year":"2007","journal-title":"Eur Heart J"},{"key":"2020022003592841500_jez272-B21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.echo.2011.02.004","article-title":"Left atrial systolic and diastolic dysfunction in heart failure with normal left ventricular ejection fraction","volume":"24","author":"Morris","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"2020022003592841500_jez272-B22","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.echo.2015.06.011","article-title":"Head-to-head comparison of global longitudinal strain measurements among nine different vendors: the EACVI\/ASE inter-vendor comparison study","volume":"28","author":"Farsalinos","year":"2015","journal-title":"J Am Soc Echocardiogr"}],"container-title":["European Heart Journal - Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/21\/3\/260\/32519951\/jez272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcimaging\/article-pdf\/21\/3\/260\/32519951\/jez272.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T08:59:40Z","timestamp":1582189180000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcimaging\/article\/21\/3\/260\/5628287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,18]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,11,18]]},"published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjci\/jez272","relation":{},"ISSN":["2047-2404","2047-2412"],"issn-type":[{"value":"2047-2404","type":"print"},{"value":"2047-2412","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3]]},"published":{"date-parts":[[2019,11,18]]}}}