{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:07:04Z","timestamp":1761102424238,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Eosinophilic myocarditis (EM) is rare but accounts for 12\u201322% of histologically proven acute myocarditis cases. Acute necrotizing EM is considered an aggressive, life-threatening disease which is usually treated by high-dose corticosteroid therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report the case of a 27-year-old man with acute severe pericarditic chest pain, moderately reduced left ventricular (LV) ejection fraction, and a small pericardial effusion. Troponin I level was highly elevated in the absence of coronary artery disease, leading to the diagnosis of acute myopericarditis. In the absence of blood eosinophilia and despite a negative cardiac magnetic resonance study, LV endomyocardial biopsy revealed an acute necrotizing EM. With conventional antiphlogistic and heart failure therapy, the patient became symptom-free and inflammatory and cardiac necrosis markers as well as LV ejection fraction normalized within days. Thus, in the absence of a systemic hypereosinophilic disorder, there was no need for steroid therapy. Long-term follow-up over 12\u2009months showed sustained normalization of cardiac structure and function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Acute necrotizing eosinophilic myopericarditis is not always a dreadful cardiac disease. There are idiopathic cases which may quickly resolve without immunosuppression. There seems to be a publication bias towards critical cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa153","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T04:23:50Z","timestamp":1592367830000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Fast spontaneous recovery from acute necrotizing eosinophilic myopericarditis without need for immunosuppressive therapy: a case report of a 27-year-old male"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-8052","authenticated-orcid":false,"given":"Michael","family":"Kindermann","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Pneumology, CaritasKlinikum St. Theresia, Academic teaching hospital of the Saarland University Faculty of Medicine, Rheinstr. 2, 66113 Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Pneumology, CaritasKlinikum St. Theresia, Academic teaching hospital of the Saarland University Faculty of Medicine, Rheinstr. 2, 66113 Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3308-7929","authenticated-orcid":false,"given":"Peter","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Pneumology, CaritasKlinikum St. Theresia, Academic teaching hospital of the Saarland University Faculty of Medicine, Rheinstr. 2, 66113 Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-2498","authenticated-orcid":false,"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[{"name":"Department of Cardiopathology, Institute for Pathology, University Hospital T\u00fcbingen, Liebermeisterstr. 8, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"2020101507244579400_ytaa153-B1","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.jacc.2017.09.023","article-title":"Eosinophilic myocarditis. Characteristics, treatment, and outcomes","volume":"70","author":"Brambatti","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2020101507244579400_ytaa153-B2","doi-asserted-by":"crossref","first-page":"2829583","DOI":"10.1155\/2016\/2829583","article-title":"Current diagnostic and therapeutic aspects of eosinophilic myocarditis","volume":"2016","author":"Kuchynka","year":"2016","journal-title":"Biomed Res Int"},{"key":"2020101507244579400_ytaa153-B3","doi-asserted-by":"crossref","first-page":"bcr2017221289","DOI":"10.1136\/bcr-2017-221289","article-title":"Eosinophilic myocarditis: an often subtle and potentially under-recognised phenomenon","volume":"2017","author":"Coughlan","year":"2017","journal-title":"BMJ Case Rep"},{"key":"2020101507244579400_ytaa153-B4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.forsciint.2016.12.037","article-title":"Demographic, clinical and pathological features of sudden deaths due to myocarditis: results from a state-wide population-based autopsy study","volume":"272","author":"Li","year":"2017","journal-title":"Forensic Sci Int"},{"key":"2020101507244579400_ytaa153-B5","first-page":"279","article-title":"Fulminant myocarditis: characteristics, treatment, and outcomes","volume":"19","author":"Veronese","year":"2018","journal-title":"Anatol J Cardiol"},{"key":"2020101507244579400_ytaa153-B6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.carpath.2014.01.004","article-title":"Detailed pathologic evaluation on endomyocardial biopsy provides long-term prognostic information in patients with acute myocarditis","volume":"23","author":"Youn","year":"2014","journal-title":"Cardiovasc Pathol"},{"key":"2020101507244579400_ytaa153-B7","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/ncpcardio0322","article-title":"Biventricular assist device placement and immunosuppression as therapy for necrotizing eosinophilic myocarditis","volume":"2","author":"Cooper","year":"2005","journal-title":"Nat Rev Cardiol"},{"key":"2020101507244579400_ytaa153-B8","first-page":"1","article-title":"Significance of troponin I level as a marker of disease activity in the management of acute necrotizing eosinophilic myocarditis with normal peripheral eosinophil count: a case report","volume":"2","author":"Kakino","year":"2018","journal-title":"Eur Heart J Case Rep"},{"key":"2020101507244579400_ytaa153-B9","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1016\/j.jacc.2018.09.072","article-title":"Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations","volume":"72","author":"Ferreira","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2020101507244579400_ytaa153-B10","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.12659\/MSM.902155","article-title":"Performance of cardiac magnetic resonance imaging for diagnosis of myocarditis compared with endomyocardial biopsy: a meta-analysis","volume":"23","author":"Wei","year":"2017","journal-title":"Med Sci Monit"},{"key":"2020101507244579400_ytaa153-B11","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1093\/eurheartj\/eht210","article-title":"Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"34","author":"Caforio","year":"2013","journal-title":"Eur Heart J"},{"key":"2020101507244579400_ytaa153-B12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1536\/ihj.52.110","article-title":"Clinical significance of corticosteroid therapy for eosinophilic myocarditis","volume":"52","author":"Yanagisawa","year":"2011","journal-title":"Int Heart J"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/4\/4\/1\/33889754\/ytaa153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/4\/4\/1\/33889754\/ytaa153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T11:33:10Z","timestamp":1602761590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/4\/4\/1\/5858284"}},"subtitle":[],"editor":[{"given":"Andre","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Francesca","family":"Musella","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Domitilla","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Milenko Zoran","family":"Cankovic","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Aref Bin","family":"Abdulhak","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Carlos Minguito","family":"Carazo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Peysh A","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,6,17]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytaa153","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,6,17]]}}}