{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:10:23Z","timestamp":1761419423936,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Vitamin K antagonists (VKAs) have been regarded as the therapy of choice for intracardiac thrombosis for decades based mostly on observational data. The advent of direct oral anticoagulants (DOACs) has displaced VKAs as the first-line therapy for multiple thrombotic disorders but not for intracardiac thrombosis. Although limited, there is growing evidence that DOACs are effective for intracardiac thrombosis and some data suggest that thrombus resolution might be superior to that with warfarin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>Here, we present a series of six patients with left atrial appendage thrombi were treated with a venous thromboembolic dose of DOACs with resolution within 2\u20136\u2009months with no reported complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case series adds to the accumulating evidence supporting the efficacy of DOACs in the treatment of intracardiac thrombi.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa181","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T17:48:03Z","timestamp":1598896083000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Novel oral anticoagulants in intracardiac thrombosis resolution: a case series"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-7887","authenticated-orcid":false,"given":"Mohammed","family":"Al-Sadawi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, SUNY Downstate, 450 Clarkson Ave Box 1199, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Francois","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, SUNY Downstate, 450 Clarkson Ave Box 1199, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romy","family":"Rodriguez Ortega","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, SUNY Downstate, 450 Clarkson Ave Box 1199, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-5548","authenticated-orcid":false,"given":"Violeta","family":"Capric","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, SUNY Downstate, 450 Clarkson Ave Box 1199, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam S","family":"Budzikowski","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Electrophysiology Section, Department of Medicine, SUNY Downstate, 450 Clarkson Ave Box 1199, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"key":"2020110901531523800_ytaa181-B1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s11239-018-1693-3","article-title":"Non-vitamin K antagonist oral anticoagulants for the treatment of intracardiac thrombosis","volume":"46","author":"Ghaffarpasand","year":"2018","journal-title":"J Thromb Thrombolysis"},{"key":"2020110901531523800_ytaa181-B2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/clc.4960180811","article-title":"Intracardiac thrombi: frequency, location, etiology, and complications: a morphologic review\u2014part I","volume":"18","author":"Waller","year":"1995","journal-title":"Clin Cardiol"},{"key":"2020110901531523800_ytaa181-B3","doi-asserted-by":"crossref","first-page":"41B","DOI":"10.1016\/S0735-1097(86)80006-7","article-title":"Antithrombotic therapy in patients with valvular heart disease and prosthetic heart valves","volume":"8","author":"Chesebro","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"2020110901531523800_ytaa181-B4","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/0735-1097(93)90409-T","article-title":"Embolic potential, prevention and management of mural thrombus complicating anterior myocardial infarction: a meta-analysis","volume":"22","author":"Vaitkus","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"2020110901531523800_ytaa181-B5","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0735-1097(85)80336-3","article-title":"Embolic potential of left ventricular thrombus after myocardial infarction: a two-dimensional echocardiographic study of 119 patients","volume":"5","author":"Visser","year":"1985","journal-title":"J Am Coll Cardiol"},{"key":"2020110901531523800_ytaa181-B6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1378\/chest.83.2.228","article-title":"Two dimensional echocardiography in the diagnosis of left ventricular thrombus. 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