{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:48:48Z","timestamp":1789602528233,"version":"build-2803163510"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Granulomatosis with polyangiitis (GPA), formerly known as Wegener\u2019s granulomatosis, is a systemic inflammatory process predominantly affecting upper and lower respiratory tract and kidneys. Valvular heart disease is a rare manifestation of GPA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report two cases of acute valvular heart disease mimicking acute endocarditis caused by GPA. Both patients were middle-aged females with acute aortic valve regurgitation suggestive of possible infective endocarditis. In their recent medical history, atypical otitis and sinusitis were noted. The first patient was admitted with heart failure and the second patient because of persisting fever. Echocardiogram revealed severe aortic regurgitation with an additional structure on two cusps, suggestive of infective endocarditis in both patients. Urgent surgical replacement was performed; however, intraoperative findings did not show infective endocarditis, but severe inflammatory changes of the valve and surrounding tissue. In both patients, the valve was replaced by a prosthetic valve. Microscopic examination of the valve\/myocardial biopsy showed diffuse acute and chronic inflammation with necrosis and necrotizing granulomas, compatible with GPA after infectious causes were excluded. Disease remission was obtained in both patients, in one patient with Rituximab and in the other with Glucocorticoids and Cyclophosphamide. Both had an uneventful follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Granulomatosis with polyangiitis can be a rare cause of acute aortic valve regurgitation mimicking infective endocarditis with the need for surgical valve replacement. Atypical ear, nose, and throat symptoms can be a first sign of GPA. Symptom recognition is important for early diagnosis and appropriate treatment to prevent further progression of the disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa307","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T06:04:25Z","timestamp":1601964265000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Aortic valve replacement due to granulomatosis with polyangiitis: a case series"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8102-7640","authenticated-orcid":false,"given":"Gilles","family":"Uijtterhaegen","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Ghent University Hospital, Corneel Heymanlaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"De Donder","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Ghent University Hospital, Corneel Heymanlaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-3775","authenticated-orcid":false,"given":"Eline","family":"Ameloot","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ghent University Hospital, Ghent, Corneel Heymanlaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8370-2590","authenticated-orcid":false,"given":"Kristof","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AZ Nikolaas, Moerlandstraat 1, 9100 Sint-Niklaas, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-4484","authenticated-orcid":false,"given":"Jo","family":"Van Dorpe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ghent University Hospital, Ghent, Corneel Heymanlaan 10, 9000 Ghent, 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