{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:52Z","timestamp":1753876252296,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The Bezold\u2013Jarisch reflex (BJR) is a cardioinhibitory parasympathetic response to activation of ventricular mechanoreceptors, which can result in bradycardia, atrioventricular block, or asystole. This phenomenon has been triggered by acute myocardial ischaemia, intra-arterial nitroglycerine use, natriuretic peptides, and with exceptional rarity, in middle-aged women only, by dobutamine infusion during stress echocardiography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present the case of a 61-year-old woman who suffered a 5.1-s sinus pause during her 20\u2009\u03bcg\/kg\/min infusion of dobutamine. Recovery was immediate following termination of dobutamine infusion. Concurrent echocardiography was normal, and subsequent cardiac catheterization and electrophysiologic study were normal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This is the fifth documented case of a severe BJR causing asystole during dobutamine infusion, which adds to the accumulating evidence supporting the benign nature of the condition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa348","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T07:46:13Z","timestamp":1605426373000},"source":"Crossref","is-referenced-by-count":1,"title":["Bezold\u2013Jarisch reflex-mediated asystole during dobutamine stress testing: a case report"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-6797","authenticated-orcid":false,"given":"Nimrah","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Medicine, NewYork-Presbyterian Brooklyn Methodist Hospital, 506 6th St, Brooklyn, NY 11215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-7023","authenticated-orcid":false,"given":"Naseem","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-7887","authenticated-orcid":false,"given":"Mohammed","family":"Al-Sadawi","sequence":"additional","affiliation":[{"name":"Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Haq","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NewYork-Presbyterian Brooklyn Methodist Hospital, 506 6th St, Brooklyn, NY 11215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"2020111502460905200_ytaa348-B1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0735-1097(83)80014-X","article-title":"The Bezold-Jarisch reflex revisited: clinical implications of inhibitory reflexes originating in the heart","volume":"1","author":"Mark","year":"1983","journal-title":"J Am Coll Cardiol"},{"key":"2020111502460905200_ytaa348-B2","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/S0735-1097(00)01012-3","article-title":"Dobutamine stress myocardial perfusion imaging","volume":"36","author":"Geleijnse","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2020111502460905200_ytaa348-B3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1213\/00000539-199607000-00061","article-title":"The Bezold-Jarisch reflex","volume":"83","author":"D'Alessio","year":"1996","journal-title":"Anesth 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