{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:18:32Z","timestamp":1778051912165,"version":"3.51.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n COVID-19 is a novel disease that has been associated with changes in haemostasis and increased risk of thrombosis, especially in patients who are critically ill.<\/jats:p>\n <\/jats:sec>\n \n Case summary<\/jats:title>\n a 71-year-old patient presented to the emergency department with acute respiratory failure. The patient had been discharged from the hospital 1 day before, after apparent recovery of a proven COVID-19 infection. Relevant medical history reports polycythemia vera. The diagnostic work-up included a CT-scan of the thorax, revealing bilateral sub-segmental pulmonary embolism. An echocardiogram showed a dilated right ventricle with poor systolic function and a large multi-lobar thrombus. Forty-eight hours after initiation of treatment with therapeutic anticoagulation the thrombus was no longer seen on the echocardiogram.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This case confirms the high risk of thrombosis in COVID-19 infection as has been described in recent literature. It demonstrates the severity of the coagulopathy given the presence of both bilateral sub-segmental pulmonary embolism and right ventricular thrombus, despite treatment with prophylactic anticoagulation. Remarkable in this case is the fact that the patient had a myeloproliferative neoplasm (polycythaemia vera). This is associated with an increased risk of thrombosis, especially in the presence of erythrocytosis, leucocytosis, and\/or inflammation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa387","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T07:34:36Z","timestamp":1605684876000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Case report of SARS Co-V2 infection, acute pulmonary embolism, and right ventricular thrombus"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6693-7355","authenticated-orcid":false,"given":"Fabienne E","family":"Vervaat","sequence":"first","affiliation":[{"name":"Department of Cardiology, Catharina hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-3344","authenticated-orcid":false,"given":"Patrick","family":"Houthuizen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"2021010812220977300_ytaa387-B1","first-page":"1116","article-title":"Prominent changes in blood coagulation of patients with SARS-CoV-2 infection","volume-title":"Clin Chem Lab Med","author":"Han","year":"2020"},{"key":"2021010812220977300_ytaa387-B2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.blre.2014.12.002","article-title":"Mechanism of thrombogenesis in polycythemia vera","volume":"29","author":"Kroll","year":"2015","journal-title":"Blood Rev"},{"key":"2021010812220977300_ytaa387-B3","author":"Mesa"},{"key":"2021010812220977300_ytaa387-B4","first-page":"e200067","article-title":"COVID-19 complicated by acute pulmonary embolism","volume":"2","author":"Xie","year":"2020","journal-title":"Radiology"},{"key":"2021010812220977300_ytaa387-B5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","journal-title":"Thromb Res"},{"key":"2021010812220977300_ytaa387-B6","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"New Eng J Med"},{"key":"2021010812220977300_ytaa387-B7","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"2021010812220977300_ytaa387-B8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur Heart J"},{"key":"2021010812220977300_ytaa387-B9","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/0002-8703(86)90361-3","article-title":"Echocardiographic findings in patients with proved pulmonary embolism","volume":"112","author":"Kasper","year":"1986","journal-title":"Am Heart J"},{"key":"2021010812220977300_ytaa387-B10","doi-asserted-by":"crossref","first-page":"e229184","DOI":"10.1136\/bcr-2019-229184","article-title":"Pulmonary embolism with right ventricular thrombus: a management dilemma","volume":"12","author":"Mujer","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2021010812220977300_ytaa387-B11","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4103\/jpcs.jpcs_54_17","article-title":"A case of mobile right ventricular thrombus with massive pulmonary thromboembolism","volume":"3","author":"Nawale","year":"2017","journal-title":"J Pract Cardiovasc Sci"},{"key":"2021010812220977300_ytaa387-B12","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2012-008214","article-title":"Intracardiac thrombosis in polycythemia vera","author":"Gangadharamurthy","year":"2013","journal-title":"BMJ Case Rep"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/4\/6\/1\/35545106\/ytaa387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/4\/6\/1\/35545106\/ytaa387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T23:54:39Z","timestamp":1610582079000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/4\/6\/1\/5986959"}},"subtitle":[],"editor":[{"given":"Tan","family":"Timothy C.","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Skott-Schmiegelow","family":"Soren","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Soliman Aboumarie","family":"Hatem","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Mukherjee","family":"Rahul","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Mehta","family":"Vishal Shahil","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,11,18]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytaa387","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12]]},"published":{"date-parts":[[2020,11,18]]}}}